Kjærgaard, M.
, Skeldal, S., Raarup, M. K.
, Nykjær, A., Nyengaard, J. R. & Nielsen, M. S. (2008).
Using FRET in the study of the Vps10pD receptors: Annual Meeting of the Nordic Microscopy Society (Scandem).
Hudecz, D., Khire, T., Chung, H. L., Adumeau, L., Glavin, D., Luke, E.
, Nielsen, M. S., Dawson, K. A., McGrath, J. L. & Yan, Y. (2020).
Ultrathin Silicon Membranes for in Situ Optical Analysis of Nanoparticle Translocation across a Human Blood-Brain Barrier Model.
ACS Nano,
14(1), 1111-1122.
https://doi.org/10.1021/acsnano.9b08870
Hudecz, D., Sigurdardóttir, S. B., Christensen, S. C., Hempel, C., Urquhart, A. J., Andresen, T. L.
& Nielsen, M. S. (2021).
Two peptides targeting endothelial receptors are internalized into murine brain endothelial cells.
PLOS ONE,
16(4 ), Article e0249686.
https://doi.org/10.1371/journal.pone.0249686
Chan, W. L., Shaw, P. C., Tam, S. C., Jacobsen, C., Gliemann, J.
& Nielsen, M. S. (2000).
Trichosanthin interacts with and enters cells via LDL receptor family members.
Biochem. Biophys. Res. Commun.,
270, 453-457.
Christensen, B., Toth, A. E., Nielsen, S. S. E.
, Scavenius, C., Petersen, S. V., Enghild, J. J., Rasmussen, J. T., Nielsen, M. S. & Sørensen, E. S. (2020).
Transport of a peptide from bovine αs1-casein across models of the intestinal and blood–brain barriers.
Nutrients,
12(10), Article 3157.
https://doi.org/10.3390/nu12103157
Hersom, M., Helms, H. C., Pretzer, N., Goldeman, C., Jensen, A. I., Severin, G.
, Nielsen, M. S., Holm, R. & Brodin, B. (2016).
Transferrin receptor expression and role in transendothelial transport of transferrin in cultured brain endothelial monolayers.
Molecular and Cellular Neuroscience,
76, 59-67.
https://doi.org/10.1016/j.mcn.2016.08.009
Gliemann, J.
, Nykjær, A., Petersen, C. M., Jørgensen, K. E.
, Nielsen, M. S., Andreasen, P.
, Christensen, E. I., Lookene, A., Olivecrona, G.
& Moestrup, S. K. (1994).
The α2-macroglobulin receptor/low density lipoprotein receptor-related protein. Binding and endocytosis of fluid-phase and membrane-associated ligands.
Ann. N. Y. Acad. Sci.,
737, 20-38.
Dennes, A.
, Madsen, P. S., Nielsen, M. S., Pedersen, J. C. M. & Pohlmann, R. (2002).
The Yeast Vps10p Cytoplasmic Tail Mediates Lysosomal Sorting in Mammalian Cells and Interacts with Human GGAs.
Journal of Biological Chemistry,
277(14), 12288-12293.
Nielsen, M. S., Madsen, P. S., Christensen, E. I., Nykjær, A., Gliemann, J., Kasper, D., Pohlmann, R.
& Pedersen, J. C. M. (2001).
The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein.
E M B O Journal,
20, 2180-2190.
Jacobsen, L.
, Madsen, P. S., Nielsen, M. S., Geraerts, W. P. M., Gliemann, J., Smit, A. B.
& Pedersen, J. C. M. (2002).
The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding.
F E B S Letters,
511(1-3), 155-158.
Kurtyka, M., Wessely, F., Bau, S., Ifie, E., He, L., de Wit, N. M., Pedersen, A. B. V., Keller, M., Webber, C., de Vries, H. E., Ansorge, O., Betsholtz, C., De Bock, M., Chaves, C., Brodin, B.
, Nielsen, M. S., Neuhaus, W., Bell, R. D., Letoha, T. ... Pietrzik, C. U. (2024).
The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier.
European Journal of Cell Biology,
103(2), Article 151406.
https://doi.org/10.1016/j.ejcb.2024.151406
Petersen, C. M., Ellgaard, L.
, Nykjær, A., Vilhardt, F., Vorum, H., Thøgersen, H. C.
, Nielsen, M. S., Jacobsen, C.
, Moestrup, S. K. & Gliemann, J. (1996).
The receptor-associated protein (RAP) binds calmodulin and is phosphorylated by calmodulin-dependent kinase II.
E M B O Journal,
15(16), 4165-4173.
Carlo, A.-S.
, Gustafsen, C., Mastrobuoni, G.
, Nielsen, M. S., Burgert, T., Hartl, D., Rohe, M.
, Nykjaer, A., Herz, J., Heeren, J., Kempa, S.
, Petersen, C. M. & Willnow, T. E. (2013).
The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid-β Peptide in the Brain.
Journal of Neuroscience,
33(1), 358-70.
https://doi.org/10.1523/JNEUROSCI.2425-12.2013
Celis, J., Rasmussen, H. H., Olsen, E.
, Madsen, P. S., Leffers, H.
, Honore, B., Dejgaard, K., Gromov, P., Hoffmann, H. J.
, Nielsen, M. S., Vassilev, A., Vintermyr, O., Hao, J., Celis, A., Basse, B., Lauridsen, J. B.
, Ratz, G. P., Andersen, A. H., Walbum, E. ... Vandekerckhove, J. (1993).
The human keratinocyte two-dimentional gel protein database: Update 1993.
Electrophoresis,
14, 1091-1198.
Celis, J., Rasmussen, H. H.
, Madsen, P. S., Leffers, H.
, Honore, B., Dejgaard, K., Gesser, B., Olsen, E., Gromov, P., Hoffmann, H. J.
, Nielsen, M. S., Celis, A., Lauridsen, J. B., Basse, B.
, Ratz, G. P., Andersen, A. H., Walbum, E., Nielsen, I. K., Nielsen, H. ... Vandekerckhove, J. (1992).
The human keratinocyte two-dimensional gel protein database: Update 1992: Towards an integrated approach to the study of cell proliferation, differentiation and skin diseases.
Electrophoresis,
13, 893-959.
Toth, A. E., Siupka, P., P Augustine, T. J., Venø, S. T., Thomsen, L. B., Moos, T., Lohi, H. T.
, Madsen, P., Lykke-Hartmann, K. & Nielsen, M. S. (2018).
The Endo-Lysosomal System of Brain Endothelial Cells Is Influenced by Astrocytes In Vitro.
Molecular Neurobiology,
55(11), 8522-8537.
https://doi.org/10.1007/s12035-018-0988-x
Toth, A. E., Nielsen, S. S. E., Tomaka, W., Abbott, N. J.
& Nielsen, M. S. (2019).
The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells.
Fluids and Barriers of the CNS,
16(1), Article 14.
https://doi.org/10.1186/s12987-019-0134-9
Leduc-Galindo, D.
, Qvist, P., Tóth, A. E., Fryland, T.
, Nielsen, M. S., Børglum, A. D. & Christensen, J. H. (2019).
The effect of hypoxia on ZEB1 expression in a mimetic system of the blood-brain barrier.
Microvascular Research,
122, 131-135.
https://doi.org/10.1016/j.mvr.2018.08.004
Gottfredsen, R. H., Tran, S. M.-H.
, Larsen, U. G., Madsen, P., Nielsen, M. S., Enghild, J. J. & Petersen, S. V. (2012).
The C-terminal proteolytic processing of extracellular superoxide dismutase is redox regulated.
Free Radical Biology & Medicine,
52(1), 191-197.
https://doi.org/10.1016/j.freeradbiomed.2011.10.443
Petersen, S. V., Thøgersen, I., Valnickova, Z.
, Nielsen, M. S., Petersen, J. S., Poulsen, E. T., Jacobsen, C., Oury, T. D.
, Moestrup, S. K., Crapo, J. D.
, Nielsen, N. C., Kristensen, T.
& Enghild, J. J. (2010).
The concentration of extracellular superoxide dismutase in plasma is maintained by LRP-mediated endocytosis.
Free Radical Biology & Medicine,
49(5), 894-9.
https://doi.org/10.1016/j.freeradbiomed.2010.06.019
Tauris, J., Ellgaard, L., Jacobsen, C.
, Nielsen, M. S., Madsen, P. S., Thøgersen, H. C., Gliemann, J.
, Petersen, C. M. & Moestrup, S. K. (1998).
The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin.
F E B S Letters,
429(1), 27-30.
Gustafsen, C., Nielsen, M. S., Madsen, P. S., Dennes, A., Schu, P.
& Petersen, C. M. (2006).
The APP binding receptor SorLA mediates Golgi-endosome shuttling. Poster session presented at EMBO research conference on Interface of Cell Biology and Cellular Microbiology. Macromolecular Complexes in Microbial Pathogenesis, Membrane Trafficking and Cell Signalling, San Feliu de Guixols, Spain.
Johnsen, K. B., Burkhart, A., Melander, F., Kempen, P. J., Vejlebo, J. B., Siupka, P.
, Nielsen, M. S., Andresen, T. L. & Moos, T. (2017).
Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma.
Scientific Reports,
7(1), 10396. Article 10396.
https://doi.org/10.1038/s41598-017-11220-1
Holst, M. R., de Wit, N. M., Ozgür, B., Brachner, A., Hyldig, K., Appelt-Menzel, A., Sleven, H., Cader, Z., de Vries, H. E., Neuhaus, W., Jensen, A., Brodin, B.
& Nielsen, M. S. (2023).
Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier.
Fluids and Barriers of the CNS,
20(1), Article 82.
https://doi.org/10.1186/s12987-023-00480-x
Nielsen, M. S., Gustafsen, C., Madsen, P., Nyengaard, J. R., Hermey, G., Bakke, O., Mari, M., Schu, P., Pohlmann, R., Dennes, A.
& Petersen, C. M. (2007).
Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA. Molecular and Cellular Biology,
27(19), 6842-51.
https://doi.org/10.1128/MCB.00815-07
Toth, A. E., Helms, H. C.
, Harazin, A., Johnsen, K. B., Goldeman, C., Burkhart, A., Thomsen, M. S., Kempen, P. J., Klepe, A., Lipka, D. V.
, Møller, P. L., Andresen, T. L., Nyegaard, M., Moos, T., Brodin, B.
& Nielsen, M. S. (2022).
Sortilin regulates blood-brain barrier integrity.
The FEBS Journal,
289(4), 1062-1079.
https://doi.org/10.1111/febs.16225
Nielsen, M. S., Jacobsen, C., Olivecrona, G., Gliemann, J.
& Petersen, C. M. (1999).
Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase.
Journal of Biological Chemistry,
274, 8832-8836.
Nykjær, A., Lee, R., Teng, K. K., Jansen, P.
, Madsen, P. S., Nielsen, M. S., Jacobsen, C., Kliemannel, M., Schwarz, E., Willnow, T. E., Hempstead, B. L.
& Pedersen, J. C. M. (2004).
Sortilin is essential for proNGF-induced neuronal cell death.
Nature,
427, 843-848.
Larsen, J. V., Hansen, M.
, Møller, B. K., Madsen, P. S., Scheller, J.
, Nielsen, M. S. & Petersen, C. M. (2010).
Sortilin Facilitates Signaling of Ciliary Neurotrophic Factor and Related Helical Type 1 Cytokines Targeting the gp130/Leukemia Inhibitory Factor Receptor β Heteromer.
Molecular and Cellular Biology,
30(17), 4175-4187.
Klinger, S. C.
, Højland, A., Gustafsen, C., Glerup, S., Kjølby, M. F., Helms, H. C., Raarup, M. K., Olivecrona, G., Brodin, B.
, Petersen, C. M., Nykjær, A. & Nielsen, M. S. (2012).
SorLA regulates trafficking of Lipoprotein Lipase in polarized cells and astrocytes. Poster session presented at Barriers of the CNS, New London NH, United States.
Klinger, S. C.
, Glerup, S., Raarup, M. K., Mari, M. C., Nyegaard, M., Koster, G.
, Prabakaran, T., Nilsson, B. S., Kjaergaard, M. M., Bakke, O.
, Nykjær, A., Olivecrona, G.
, Petersen, C. M. & Nielsen, M. S. (2011).
SorLA regulates the activity of lipoprotein lipase by intracellular trafficking.
Journal of Cell Science,
124(Pt 7), 1095-105.
https://doi.org/10.1242/jcs.072538
Toth, A. E., Klepe, A., Lipka, D. V., Goldeman, C., Brodin, B.
& Nielsen, M. S. (2023).
SorLA in astrocytes regulates blood-brain barrier integrity.
Frontiers in Drug Delivery,
2.
https://doi.org/10.3389/fddev.2022.1082689
Westergaard, U. B.
, Kirkegaard, K., Sørensen, E. S., Jacobsen, C.
, Nielsen, M. S., Pedersen, J. C. M. & Madsen, P. S. (2005).
SorCS3 does not require propeptide cleavage to bind nerve growth factor.
F E B S Letters,
579(5), 1172-1176.
Nielsen, M. S., Brejning, J., García, R., Zhang, H., Hayden, M. R., Vilaró, S. & Gliemann, J. (1997).
Segments in the C-terminal folding domain of lipoprotein lipase important for binding to the low density lipoprotein receptor-related protein and to heparan sulfate proteoglycans.
Journal of Biological Chemistry,
272(9), 5821-5827.
http://www.jbc.org/cgi/content/full/272/9/5821
Petersen, C. M., Nielsen, M. S., Jacobsen, C., Tauris, J., Jacobsen, L., Gliemann, J.
, Moestrup, S. K. & Madsen, P. S. (1999).
Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding.
E M B O Journal,
18, 595-604.
Alam, P.
, Holst, M. R., Lauritsen, L.
, Nielsen, J., Nielsen, S. S. E.
, Jensen, P. H., Brewer, J. R.
, Otzen, D. E. & Nielsen, M. S. (2022).
Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers.
Fluids and Barriers of the CNS,
19(1), Article 37.
https://doi.org/10.1186/s12987-022-00334-y
Klinger, S. C.
, Højland, A., Jain, S.
, Kjolby, M., Madsen, P., Svendsen, A. D., Olivecrona, G., Bonifacino, J. S.
& Nielsen, M. S. (2016).
Polarized Trafficking of the Sorting Receptor SorLA in Neurons and MDCK Cells.
F E B S Journal,
283(13), 2476–2493.
https://doi.org/10.1111/febs.13758
Navarro, V., Martin, S., Sarret, P.
, Nielsen, M. S., Pedersen, J. C. M., Vincent, J.-P. & Mazella, J. (2001).
Pharmacological properties of the mouse neurotensin receptor 3. Maintenance of cell surface receptor during internalization of neurotensin.
F E B S Letters,
495, 100-105.