Yan, Y., Gu, T.
, Christensen, S. D. K., Su, J., Lassen, T. R., Hjortbak, M. V., Lo, I., Venø, S. T., Tóth, A. E.
, Song, P., Nielsen, M. S., Bøtker, H. E., Blagoev, B.
, Drasbek, K. R. & Kjems, J. (2021).
Cyclic hypoxia conditioning alters the content of myoblast-derived extracellular vesicles and enhances their cell-protective functions.
Biomedicines,
9(9), Article 1211.
https://doi.org/10.3390/biomedicines9091211
Westergaard, U. B.
, Sørensen, E. S., Hermey, G.
, Nielsen, M. S., Nykjær, A., Kirkegaard, K., Jacobsen, C., Gliemann, J.
, Madsen, P. S. & Pedersen, J. C. M. (2004).
Functional organization of the sortilin Vps10p domain.
Journal of Biological Chemistry,
279, 50221-50229.
Westergaard, U. B.
, Kirkegaard, K., Sørensen, E. S., Jacobsen, C.
, Nielsen, M. S., Pedersen, J. C. M. & Madsen, P. S. (2005).
SorCS3 does not require propeptide cleavage to bind nerve growth factor.
F E B S Letters,
579(5), 1172-1176.
Toth, A. E., Siupka, P., P Augustine, T. J., Venø, S. T., Thomsen, L. B., Moos, T., Lohi, H. T.
, Madsen, P., Lykke-Hartmann, K. & Nielsen, M. S. (2018).
The Endo-Lysosomal System of Brain Endothelial Cells Is Influenced by Astrocytes In Vitro.
Molecular Neurobiology,
55(11), 8522-8537.
https://doi.org/10.1007/s12035-018-0988-x
Toth, A. E., Nielsen, S. S. E., Tomaka, W., Abbott, N. J.
& Nielsen, M. S. (2019).
The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells.
Fluids and Barriers of the CNS,
16(1), Article 14.
https://doi.org/10.1186/s12987-019-0134-9
Toth, A. E., Helms, H. C.
, Harazin, A., Johnsen, K. B., Goldeman, C., Burkhart, A., Thomsen, M. S., Kempen, P. J., Klepe, A., Lipka, D. V.
, Møller, P. L., Andresen, T. L., Nyegaard, M., Moos, T., Brodin, B.
& Nielsen, M. S. (2022).
Sortilin regulates blood-brain barrier integrity.
The FEBS Journal,
289(4), 1062-1079.
https://doi.org/10.1111/febs.16225
Toth, A. E., Klepe, A., Lipka, D. V., Goldeman, C., Brodin, B.
& Nielsen, M. S. (2023).
SorLA in astrocytes regulates blood-brain barrier integrity.
Frontiers in Drug Delivery,
2.
https://doi.org/10.3389/fddev.2022.1082689
Tauris, J., Ellgaard, L., Jacobsen, C.
, Nielsen, M. S., Madsen, P. S., Thøgersen, H. C., Gliemann, J.
, Petersen, C. M. & Moestrup, S. K. (1998).
The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin.
F E B S Letters,
429(1), 27-30.
Strandgaard, T., Foder, S.
, Heuck, A., Ernst, E., Nielsen, M. S. & Lykke-Hartmann, K. (2017).
Maternally Contributed Folate Receptor 1 Is Expressed in Ovarian Follicles and Contributes to Preimplantation Development.
Frontiers in Cell and Developmental Biology,
5(SEP), Article 89.
https://doi.org/10.3389/fcell.2017.00089
Siupka, P., Hersom, M. N.
, Lykke-Hartmann, K., Johnsen, K. B., Thomsen, L. B., Andresen, T. L., Moos, T., Abbott, N. J., Brodin, B.
& Nielsen, M. S. (2017).
Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells.
Journal of Cerebral Blood Flow and Metabolism,
37(7), 2598-2613. Article 271678X17700665.
https://doi.org/10.1177/0271678X17700665
Sarret, P., Krzykowski, P., Segal, L.
, Nielsen, M. S., Pedersen, J. C. M., Mazella, J., Stroh, T. & Beaudet, A. (2003).
Distribution of NTS3 receptor/sortilin mRNA and protein in the rat central nervous system.
J. Comp. Neurol., (461), 483-505.
Progida, C.
, Nielsen, M. S., Koster, G., Bucci, C. & Bakke, O. (2012).
Dynamics of Rab7b-dependent transport of sorting receptors.
Traffic,
13(9), 1273–1285.
https://doi.org/10.1111/j.1600-0854.2012.01388.x
Petersen, C. M., Ellgaard, L.
, Nykjær, A., Vilhardt, F., Vorum, H., Thøgersen, H. C.
, Nielsen, M. S., Jacobsen, C.
, Moestrup, S. K. & Gliemann, J. (1996).
The receptor-associated protein (RAP) binds calmodulin and is phosphorylated by calmodulin-dependent kinase II.
E M B O Journal,
15(16), 4165-4173.
Petersen, C. M., Nielsen, M. S., Jacobsen, C., Tauris, J., Jacobsen, L., Gliemann, J.
, Moestrup, S. K. & Madsen, P. S. (1999).
Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding.
E M B O Journal,
18, 595-604.
Petersen, C. M., Nielsen, M. S., Nykjær, A., Jacobsen, L., Tommerup, N., Rasmussen, H., Røigaard, H., Gliemann, J.
, Madsen, P. S. & Moestrup, S. K. (1997).
Molecular identification of anovel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography.
Journal of Biological Chemistry,
272, 3599-3605.
Petersen, S. V., Thøgersen, I., Valnickova, Z.
, Nielsen, M. S., Petersen, J. S., Poulsen, E. T., Jacobsen, C., Oury, T. D.
, Moestrup, S. K., Crapo, J. D.
, Nielsen, N. C., Kristensen, T.
& Enghild, J. J. (2010).
The concentration of extracellular superoxide dismutase in plasma is maintained by LRP-mediated endocytosis.
Free Radical Biology & Medicine,
49(5), 894-9.
https://doi.org/10.1016/j.freeradbiomed.2010.06.019
Ozgür, B., Puris, E., Brachner, A., Appelt-Menzel, A., Oerter, S., Balzer, V.
, Holst, M. R., Christiansen, R. F., Hyldig, K., Buckley, S. T., Kristensen, M., Auriola, S., Jensen, A., Fricker, G.
, Nielsen, M. S., Neuhaus, W. & Brodin, B. (2023).
Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line.
Fluids and Barriers of the CNS,
20(1), Article 96.
https://doi.org/10.1186/s12987-023-00501-9
Nykjær, A., Fyfe, J. C., Kozyraki, R., Leheste, J. R., Jacobsen, C.
, Nielsen, M. S., Verroust, P. J., Aminoff, M., de la Chapelle, A.
, Moestrup, S. K., Ray, R., Gliemann, J., Willnow, T. E.
& Christensen, E. I. (2001).
Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3).
Proceedings of the National Academy of Sciences,
98, 13895-13900.
Nykjær, A., Lee, R., Teng, K. K., Jansen, P.
, Madsen, P. S., Nielsen, M. S., Jacobsen, C., Kliemannel, M., Schwarz, E., Willnow, T. E., Hempstead, B. L.
& Pedersen, J. C. M. (2004).
Sortilin is essential for proNGF-induced neuronal cell death.
Nature,
427, 843-848.
Nykjær, A., Nielsen, M. S., Meyer, M., Røigaard, H., Etzerodt, M., Lookene, A., Beisiegel, U., Olivecrona, G. & Gliemann, J. (1994).
A C-terminal fragment of lipoprotein lipase binds to LDL receptor-related protein and inhibits lipase-mediated uptake of β-VLDL lipoprotien particles.
Journal of Biological Chemistry,
267, 31747-31755.
Nyegaard, M., Rendtorff, N. D.
, Nielsen, M. S., Corydon, T. J., Demontis, D., Starnawska, A., Hedemand, A., Buniello, A., Niola, F., Overgaard, M. T., Leal, S. M., Ahmad, W.
, Wikman, F. P., Petersen, K. B., Crüger, D. G., Oostrik, J., Kremer, H., Tommerup, N., Frödin, M.
... Børglum, A. D. (2015).
A Novel Locus Harbouring a Functional CD164 Nonsense Mutation Identified in a Large Danish Family with Nonsyndromic Hearing Impairment.
P L o S Genetics,
11(7), e1005386.
https://doi.org/10.1371/journal.pgen.1005386
Nilsson, S. K., Christensen, S., Raarup, M. K., Ryan, R. O.
, Nielsen, M. S. & Olivecrona, G. (2008).
Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families.
Journal of Biological Chemistry,
283(38), 25920-7.
https://doi.org/10.1074/jbc.M802721200
Nielsen, M. S., Madsen, P. S., Christensen, E. I., Nykjær, A., Gliemann, J., Kasper, D., Pohlmann, R.
& Pedersen, J. C. M. (2001).
The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein.
E M B O Journal,
20, 2180-2190.
Nielsen, M. S., Brejning, J., García, R., Zhang, H., Hayden, M. R., Vilaró, S. & Gliemann, J. (1997).
Segments in the C-terminal folding domain of lipoprotein lipase important for binding to the low density lipoprotein receptor-related protein and to heparan sulfate proteoglycans.
Journal of Biological Chemistry,
272(9), 5821-5827.
http://www.jbc.org/cgi/content/full/272/9/5821
Nielsen, M. S., Jacobsen, C., Olivecrona, G., Gliemann, J.
& Petersen, C. M. (1999).
Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase.
Journal of Biological Chemistry,
274, 8832-8836.
Nielsen, M. S., Nykjær, A., Warshawsky, I., Schwartz, A. L. & Gliemann, J. (1995).
Analysis of ligand binding to the α2-macroglobulin receptor/low density lipoprotein receptor-related protein.
Journal of Biological Chemistry,
270, 23713-23719.
Nielsen, M. S., Gustafsen, C., Madsen, P., Nyengaard, J. R., Hermey, G., Bakke, O., Mari, M., Schu, P., Pohlmann, R., Dennes, A.
& Petersen, C. M. (2007).
Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA. Molecular and Cellular Biology,
27(19), 6842-51.
https://doi.org/10.1128/MCB.00815-07
Nielsen, S. S. E., Siupka, P., Georgian, A., Preston, J. E., Tóth, A. E., Yusof, S. R., Abbott, N. J.
& Nielsen, M. S. (2017).
Improved Method for the Establishment of an In Vitro Blood-Brain Barrier Model Based on Porcine Brain Endothelial Cells.
Journal of Visualized Experiments,
2017(127), Article e56277.
https://doi.org/10.3791/56277
Nielsen, S. S. E.
, Holst, M. R., Langthaler, K., Christensen, S. C.
, Bruun, E. H., Brodin, B.
& Nielsen, M. S. (2023).
Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells.
Fluids and Barriers of the CNS,
20(1), Article 2.
https://doi.org/10.1186/s12987-022-00404-1
Navarro, V., Martin, S., Sarret, P.
, Nielsen, M. S., Pedersen, J. C. M., Vincent, J.-P. & Mazella, J. (2001).
Pharmacological properties of the mouse neurotensin receptor 3. Maintenance of cell surface receptor during internalization of neurotensin.
F E B S Letters,
495, 100-105.
Matrone, C., Dzamko, N.
, Madsen, P., Nyegaard, M., Pohlmann, R., Søndergaard, R. V., Lassen, L. B., Andresen, T. L., Halliday, G. M.
, Jensen, P. H. & Nielsen, M. S. (2016).
Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease.
PLOS ONE,
11(8), e0160501. Article e0160501.
https://doi.org/10.1371/journal.pone.0160501
Madsen, P., Isaksen, T. J., Siupka, P., Tóth, A. E., Nyegaard, M.
, Gustafsen, C. & Nielsen, M. S. (2019).
HSPA12A targets the cytoplasmic domain and affects the trafficking of the Amyloid Precursor Protein receptor SorLA.
Scientific Reports,
9, Article 611.
https://doi.org/10.1038/s41598-018-37336-6
Leffers, H., Dejgaard, K.
, Honore, B., Madsen, P. S., Nielsen, M. S. & Celis, J. (1996).
cDNA expression and human two-dimentional gel protein databases: Towards integrating DNA and protein information.
Electrophoresis,
17, 1713-1719.
Leffers, H.
, Nielsen, M. S., Andersen, A. H.
, Honore, B., Madsen, P. S., Vandekerckhove, J. & Celis, J. (1993).
Identification of two human Rho GDP-dissociation inhibitor protein whose overexpression leads to disruption of the acting cytoskeleton.
Exp. Cell Res.,
209, 165-174.
Leduc-Galindo, D.
, Qvist, P., Tóth, A. E., Fryland, T.
, Nielsen, M. S., Børglum, A. D. & Christensen, J. H. (2019).
The effect of hypoxia on ZEB1 expression in a mimetic system of the blood-brain barrier.
Microvascular Research,
122, 131-135.
https://doi.org/10.1016/j.mvr.2018.08.004
Larsen, J. V., Hansen, M.
, Møller, B. K., Madsen, P. S., Scheller, J.
, Nielsen, M. S. & Petersen, C. M. (2010).
Sortilin Facilitates Signaling of Ciliary Neurotrophic Factor and Related Helical Type 1 Cytokines Targeting the gp130/Leukemia Inhibitory Factor Receptor β Heteromer.
Molecular and Cellular Biology,
30(17), 4175-4187.
Larsen, J. V., Kristensen, A. M.
, Pallesen, L. T., Bauer, J.
, Vægter, C. B., Nielsen, M. S., Madsen, P. & Petersen, C. M. (2016).
Cytokine-like factor-1 (CLF-1): An essential facilitator of cardiotrophin-like cytokine: CNTFRα (CLC:CNTFRα) signalling and sorLA mediated turnover.
Molecular and Cellular Biology.
https://doi.org/10.1128/mcb.00917-15
Kurtyka, M., Wessely, F., Bau, S., Ifie, E., He, L., de Wit, N. M., Pedersen, A. B. V., Keller, M., Webber, C., de Vries, H. E., Ansorge, O., Betsholtz, C., De Bock, M., Chaves, C., Brodin, B.
, Nielsen, M. S., Neuhaus, W., Bell, R. D., Letoha, T. ... Pietrzik, C. U. (2024).
The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier.
European Journal of Cell Biology,
103(2), Article 151406.
https://doi.org/10.1016/j.ejcb.2024.151406
Kristensen, M., Kucharz, K., Felipe Alves Fernandes, E., Strømgaard, K.
, Schallburg Nielsen, M., Cederberg Helms, H. C., Bach, A., Ulrikkaholm Tofte-Hansen, M., Irene Aldana Garcia, B., Lauritzen, M. & Brodin, B. (2020).
Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation.
Pharmaceutics,
12(7), 1-24. Article 661.
https://doi.org/10.3390/pharmaceutics12070661
Krapp, A., Ahle, S., Kersting Hua, Y., Kneser, K.
, Nielsen, M. S., Gliemann, J. & Beisiegel, U. (1996).
Hepatic lipase mediates the uptake of chylomicrons and β-VLDL into cells via the LDL receptor-related protein (LRP).
J. Lipid Res.,
37, 926-936.
Klinger, S. C.
, Glerup, S., Raarup, M. K., Mari, M. C., Nyegaard, M., Koster, G.
, Prabakaran, T., Nilsson, B. S., Kjaergaard, M. M., Bakke, O.
, Nykjær, A., Olivecrona, G.
, Petersen, C. M. & Nielsen, M. S. (2011).
SorLA regulates the activity of lipoprotein lipase by intracellular trafficking.
Journal of Cell Science,
124(Pt 7), 1095-105.
https://doi.org/10.1242/jcs.072538
Klinger, S. C.
, Højland, A., Gustafsen, C., Glerup, S., Kjølby, M. F., Helms, H. C., Raarup, M. K., Olivecrona, G., Brodin, B.
, Petersen, C. M., Nykjær, A. & Nielsen, M. S. (2012).
SorLA regulates trafficking of Lipoprotein Lipase in polarized cells and astrocytes. Poster session presented at Barriers of the CNS, New London NH, United States.