Kjølby, M. F., Andersen, O. M., Breiderhoff, T.
, Fjorback, A. N., Pedersen, K.-M., Madsen, P. S., Jansen, P., Heeren, J., Willnow, T.
& Nykjær, A. (2010).
Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export. Cell Metabolism,
12(3), 213-223.
Reiche, J., Theilig, F., Rafiqi, F. H., Militz, D., Mutig, K., Todiras, M.
, Christensen, E. I., Ellison, D. H., Bader, M.
, Nykjaer, A., Bachmann, S., Alessi, D. & Willnow, T. E. (2010).
SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na+-K+-Cl- cotransporter 2.
Molecular and Cellular Biology,
30, 3027-3037.
https://doi.org/10.1128/MCB.01560-09Klinger, S. C., Højland, A., Gustafsen, C., Glerup, S., Kjølby, M. F., Helms, H. C.
, Raarup, M. K., Olivecrona, G., Brodin, B.
, Petersen, C. M., Nykjær, A. & Nielsen, M. S. (2012).
SorLA regulates trafficking of Lipoprotein Lipase in polarized cells and astrocytes. Poster session presented at Barriers of the CNS, New London NH, United States.
Klinger, S. C., Glerup, S., Raarup, M. K., Mari, M. C.
, Nyegaard, M., Koster, G.
, Prabakaran, T., Nilsson, B. S.
, Kjaergaard, M. M., Bakke, O.
, Nykjær, A., Olivecrona, G.
, Petersen, C. M. & Nielsen, M. S. (2011).
SorLA regulates the activity of lipoprotein lipase by intracellular trafficking.
Journal of Cell Science,
124(Pt 7), 1095-105.
https://doi.org/10.1242/jcs.072538
Klinger, S. C., Glerup, S., Raarup, M. K., Mari, MC.
, Nyegaard, M., Koster, G.
, Prabakaran, T., Nilsson, SK.
, Kjærgaard, M. M., Bakke, O.
, Nykjær, A., Olivecrona, G.
, Petersen, C. M. & Nielsen, MS. (2011).
SorLA regulates lipoprotein lipase activity by intracellular trafficking. Poster session presented at PhD Day 2011, Aarhus University, Faculty of Health Sciences, Aarhus, Denmark.
Klinger, S. C., Glerup, S., Raarup, M. K., Mari, MC.
, Nyegaard, M., Koster, G.
, Prabakaran, T., Nilsson, SK.
, Kjærgaard, M. M., Bakke, O.
, Nykjær, A., Olivecrona, G.
, Petersen, C. M. & Nielsen, MS. (2011).
SorLA regulates lipoprotein lipase activity by intracellular trafficking. Abstract from PhD Day 2011, Aarhus University, Faculty of Health Sciences, Aarhus, Denmark.
Burgert, T., Schmidt, V., Caglayan, S.
, Lin, F., Füchtbauer, A., Füchtbauer, E.-M., Nykjaer, A., Carlo, A.-S. & Willnow, T. E. (2013).
SORLA-Dependent and -Independent Functions for PACS1 in Control of Amyloidogenic Processes.
Molecular and Cellular Biology,
33(21), 4308-4320.
https://doi.org/10.1128/MCB.00628-13Glerup, S., Lume, M.
, Olsen, D., Nyengaard, J. R., Vaegter, C. B., Gustafsen, C., Christensen, E. I., Kjolby, M., Hay-Schmidt, A.
, Bender, D., Madsen, P., Saarma, M.
, Nykjaer, A. & Petersen, C. M. (2013).
SorLA Controls Neurotrophic Activity by Sorting of GDNF and Its Receptors GFRα1 and RET.
Cell Reports,
3, 186-199.
https://doi.org/10.1016/j.celrep.2012.12.011
Glerup, S., Olsen, D., Vægter, C. B., Gustafsen, C., Sjøgaard, S., Hermey, G., Kjølby, M. F., Jensen, S. M., Ulrichsen, M., Hansen, S. B., Skeldal, S.
, Fjorback, A. N., Nyengaard, J. R., Jacobsen, J.
, Bender, D., Bjarkam, C. R.
, Sørensen, E. S., Füchtbauer, E.-M., Eichele, G.
... Nykjær, A. (2014).
SorCS2 Regulates Dopaminergic Wiring and Is Processed into an Apoptotic Two-Chain Receptor in Peripheral Glia.
Neuron,
82(5), 1074–1087.
https://doi.org/10.1016/j.neuron.2014.04.022
Staehr, C., Login, H., Postnov, D., Berenji Ardestani, S., Nolte, S. S., Beck, H. C.
, Nykjær, A. & Matchkov, V. (2023).
SorCS2 modulates neurovascular coupling via glutamatergic and calcium signaling in astrocytes. bioRxiv.
https://doi.org/10.1101/2023.02.16.528727
Glerup, S., Bolcho, U., Bøggild, S., Vaegter, C. B., Smith, A. H., Nieto-Gonzalez, J. L., Ovesen, P. L., Pedersen, L. F., Fjorback, A. N., Kjolby, M., Login, H., Holm, M. M., Andersen, O. M., Nyengaard, J. R., Willnow, T. E.
, Jensen, K., Nykjaer, A. & Jensen, S. M. (2016).
SorCS2 is required for BDNF-dependent plasticity in the hippocampus.
Molecular Psychiatry,
21(12), 1740-1751.
https://doi.org/10.1038/mp.2016.108
Staehr, C., Login, H., Melnikova, E., Bakun, M., Ziemlinska, E.
, Kisiswa, L., Berenji Ardestani, S., Nolte, S. S., Beck, H. C.
, Hansen, L. M. B., Postnov, D., Verkhratsky, A., Malik, A. R.
, Nykjær, A. & Matchkov, V. (2025).
SorCS2 Is Important for Astrocytic Function in Neurovascular Signaling.
Acta Physiologica (Print),
241(6), Article e70052.
https://doi.org/10.1111/apha.70052
Salasova, A., Degn, N. S., Paveliev, M., Madsen, N. K., Ovesen, P. L., Vestergaard , B., Udrea, A.-C., Kisiswa, L., Woloszczuková, L., Faress, I. M. G., Nabavi, S., Holm, M. M., Kjolby, M., Bølcho, U. & Nykjær, A. (2021).
SorCS2 dynamically interacts with TrkB and GluN2B to control neurotransmission and Huntington's disease progression.
https://doi.org/10.1101/2021.11.03.466767
Malik, A. R., Szydlowska, K., Nizinska, K., Asaro, A., van Vliet, E. A., Popp, O., Dittmar, G., Fritsche-Guenther, R., Kirwan, J. A.
, Nykjaer, A., Lukasiuk, K., Aronica, E. & Willnow, T. E. (2019).
SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology.
Cell Reports,
26(10), 2792-2804.e6.
https://doi.org/10.1016/j.celrep.2019.02.027Thomasen, P. B., Salasova, A., Kjaer-Sorensen, K., Woloszczuková, L., Lavický, J.
, Login, H., Tranberg-Jensen, J., Almeida, S., Beel, S., Kavková, M.
, Qvist, P., Kjolby, M., Ovesen, P. L., Nolte, S., Vestergaard, B., Udrea, A.-C., Nejsum, L. N., Chao, M. V., Van Damme, P.
... Nykjaer, A. (2023).
SorCS2 binds progranulin to regulate motor neuron development.
Cell Reports,
42(11), Article 113333.
https://doi.org/10.1016/j.celrep.2023.113333
Kjolby, M., Pedersen, K. M., Breining, P., Wellner, N., Sørensen, K. M. J., Vittrup, D. M., Gjesing, A. M. P.
, Januliene, D., Manavalan, A., Rotman, M., Thotakura, G., Skeldal, S., Madsen, P.
, Thirup, S., Hermey, G.
, Vaegter, C. B., Möller, A., Asplund, O., Prasad, R. B.
... Nykjaer, A. (2020).
SorCS1 binds the insulin receptor to enhance insulin sensitivity. bioRxiv.
https://doi.org/10.1101/2020.11.10.376178
Molgaard, S., Demontis, D., Nicholson, A. M., Finch, N. A., Petersen, R. C.
, Petersen, C. M., Rademakers, R.
, Nykjaer, A. & Glerup, S. (2016).
Soluble sortilin is present in excess and positively correlates with progranulin in CSF of aging individuals.
Experimental Gerontology,
84, 96-100.
https://doi.org/10.1016/j.exger.2016.09.002
Gould, E., Fraser, H. S., Parker, T. H., Nakagawa, S., Griffith, S. C., Vesk, P. A., Fidler, F., Hamilton, D. G., Abbey-Lee, R. N., Abbott, J. K., Aguirre, L. A., Alcaraz, C., Aloni, I., Altschul, D., Arekar, K., Atkins, J. W.
, Atkinson, J., Baker, C. M., Barrett, M. ... Zitomer, R. A. (2025).
Same data, different analysts: variation in effect sizes due to analytical decisions in ecology and evolutionary biology.
BMC Biology,
23(1), Article 35.
https://doi.org/10.1186/s12915-024-02101-xJansen, P., Giehl, K., Nyengaard, J. R., Teng, K., Lioubinski, O.
, Sjoegaard, S. S., Breiderhoff, T., Gotthardt, M.
, Lin, F., Eilers, A.
, Petersen, C. M., Lewin, G. R., Hempstead, B. L., Willnow, T. E.
& Nykjaer, A. (2007).
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nature Neuroscience,
10(11), 1449-57.
https://doi.org/10.1038/nn2000
Hammes, A.
, Andreassen, T. K., Spoelgen, R., Raila, J., Huebner, N., Schulz, H., Metzger, J., Schweigert, F. J., Luppa, P. B.
, Nykjær, A. & Willnow, T. E. (2005).
Role of endocytosis in cellular uptake of sex steroids.
Cell,
122, 751-762.
Kjolby, M. (2024).
RNA-terapeutika. In U. Simonsen, K. P. Dalhoff, T. K. Bergmann & M. Rosenkilde (Eds.),
Basal og klinisk farmakologi 7. udgave (7 ed., pp. 79-83). FADL's Forlag.
Jensen, M. H.
, Kjolby, M., Hejlesen, O., Jakobsen, P. E. & Vestergaard, P. (2020).
Risk of Major Adverse Cardiovascular Events, Severe Hypoglycemia, and All-Cause Mortality for Widely Used Antihyperglycemic Dual and Triple Therapies for Type 2 Diabetes Management: A Cohort Study of All Danish Users. Diabetes Care,
43(6), 1209-1218.
https://doi.org/10.2337/dc19-2535Smith, A. H.
, Ovesen, P. L., Skeldal, S., Yeo, S., Jensen, K. P.
, Olsen, D., Diazgranados, N., Zhao, H., Farrer, L. A., Goldman, D.
, Glerup, S., Kranzler, H. R.
, Nykjaer, A. & Gelernter, J. (2018).
Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2.
Alcoholism: Clinical and Experimental Research,
42(12), 2337-2348.
https://doi.org/10.1111/acer.13890Fjorback, A. W., Seaman, M.
, Gustafsen, C., Mehmedbasic, A., Gokool, S., Wu, C., Militz, D., Schmidt, V.
, Madsen, P., Nyengaard, J. R., E Willnow, T.
, Christensen, E. I., B Mobley, W.
, Nykjær, A. & Andersen, O. M. (2012).
Retromer Binds the FANSHY Sorting Motif in SorLA to Regulate Amyloid Precursor Protein Sorting and Processing.
Journal of Neuroscience,
32(4), 1467-1480.
https://doi.org/10.1523/JNEUROSCI.2272-11.2012
Hagensen, M. K., Mortensen, M. B., Kjolby, M., Stillits, N. L., Steffensen, L. B. & Bentzon, J. F. (2017).
Reply to "Bioinformatics analysis in type 1 diabetes increases retention of low-density lipoprotein in the atherosclerosis-prone area of the murine aorta".
Atherosclerosis. Supplement,
263, 428-429.
https://doi.org/10.1016/j.atherosclerosis.2017.06.926
Olsen, D., Kaas, M., Lundhede, J., Molgaard, S., Nykjær, A., Kjolby, M., Østergaard, S. D. & Glerup, S. (2019).
Reduced Alcohol Seeking and Withdrawal Symptoms in Mice Lacking the BDNF Receptor SorCS2.
Frontiers in Pharmacology,
10(MAY), Article 499.
https://doi.org/10.3389/fphar.2019.00499
Andreasen, P. A.
, Sottrup-Jensen, L., Kjøller, L.
, Nykjaer, A., Moestrup, S. K., Petersen, C. M. & Gliemann, J. (1994).
Receptor-mediated endocytosis of plasminogen activators and activator/inhibitor complexes.
FEBS Letters,
338(3), 239-45.
http://www.febsletters.org/medline/record/MDLN.8307187Schmidt, V., Baum, K., Lao, A., Rateitschak, K., Schmitz, Y., Teichmann, A., Wiesner, B.
, Petersen, C. M., Nykjaer, A., Wolf, J., Wolkenhauer, O. & Willnow, T. E. (2012).
Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease.
EMBO Journal,
31(1), 187-200.
https://doi.org/10.1038/emboj.2011.352Nykjær, A., Petersen, C. M., Møller, B.
, Jensen, P. H., Moestrup, S. K., Holtet, T. L.
, Etzerodt, M., Thøgersen, H. C., Munch, M.
, Andreasen, P. & Gliemann, J. (1992).
Purified alpha(2)-Macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha(2)-Macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.
Journal of Biological Chemistry,
267(21), 14543-14546.
Siao, C.-J., Lorentz, C. U., Kermani, P., Marinic, T., Carter, J. D., McGrath, K., Padow, V. A., Mark, W., Falcone, D. J., Cohen-Gould, L., Parrish, D. C., Habecker, B. A.
, Nykjaer, A., Ellenson, L. H., Tessarollo, L. & Hempstead, B. L. (2012).
ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation.
The Tohoku Journal of Experimental Medicine,
209(12), 2291-305.
https://doi.org/10.1084/jem.20111749Tauris, J., Gustafsen, C., Christensen, E. I., Jansen, P., Nykjaer, A., Nyengaard, J. R., Teng, K. K., Schwarz, E.
, Ovesen, T., Madsen, P. & Petersen, C. M. (2011).
Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons.
European Journal of Neuroscience,
33, 622-631.
https://doi.org/10.1111/j.1460-9568.2010.07556.x
Gass, J., Lee, W. C., Cook, C., Finch, N., Stetler, C., Jansen-West, K., Lewis, J., Link, C. D., Rademakers, R.
, Nykjær, A. & Petrucelli, L. (2012).
Progranulin regulates neuronal outgrowth independent of Sortilin.
Molecular Neurodegeneration,
7, 33.
https://doi.org/10.1186/1750-1326-7-33Buttenschøn, H. N., Nielsen, M. N., Thotakura, G., Lee, C. W.
, Nykjær, A., Mors, O. & Glerup, S. (2017).
Progranulin gene variation affects serum progranulin levels differently in Danish bipolar individuals compared with healthy controls.
Psychiatric Genetics,
27(3), 89-95.
https://doi.org/10.1097/YPG.0000000000000168
Teng, H. K., Teng, K. K., Lee, R., Wright, S., Tevar, S., Almeida, R. D., Kermani, P., Torkin, R., Chen, Z. Y., Lee, F. S., Kraemer, R. T.
, Nykjær, A. & Hempstead, B. L. (2005).
ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin.
Journal of Neuroscience,
25, 5455-5463.
Uchiyama, K., Tomita, M., Yano, M., Chida, J., Hara, H., Das, N. R.
, Nykjaer, A. & Sakaguchi, S. (2017).
Prions amplify through degradation of the VPS10P sorting receptor sortilin.
PLoS Pathogens,
13(6), e1006470. Article e1006470.
https://doi.org/10.1371/journal.ppat.1006470Pottier, C., Zhou, X., Perkerson, R. B., Baker, M., Jenkins, G. D., Serie, D. J., Ghidoni, R., Benussi, L., Binetti, G., López de Munain, A., Zulaica, M., Moreno, F., Le Ber, I., Pasquier, F., Hannequin, D., Sánchez-Valle, R., Antonell, A., Lladó, A., Parsons, T. M. ... Rademakers, R. (2018).
Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.
The Lancet Neurology,
17(6), 548-558.
https://doi.org/10.1016/S1474-4422(18)30126-1Klinger, S. C., Højland, A., Jain, S.
, Kjolby, M., Madsen, P., Svendsen, A. D., Olivecrona, G., Bonifacino, J. S.
& Nielsen, M. S. (2016).
Polarized Trafficking of the Sorting Receptor SorLA in Neurons and MDCK Cells.
FEBS journal,
283(13), 2476–2493.
https://doi.org/10.1111/febs.13758
Hjelholt, A. J., Bergh, C., Bhatt, D. L.
, Fröbert, O. & Kjolby, M. F. (2023).
Pleiotropic Effects of Influenza Vaccination.
Vaccines,
11(9), Article 1419.
https://doi.org/10.3390/vaccines11091419
Etzerodt, A., Kjolby, M., Nielsen, M. J., Maniecki, M. B., Svendsen, P. & Moestrup, S. K. (2013).
Plasma clearance of hemoglobin and haptoglobin in mice and effect of CD163 gene targeting disruption.
Antioxidants & Redox Signaling,
18(17), 2254-2263.
https://doi.org/10.1089/ars.2012.4605
Hansen, J. S., Boix, F.
, Hasselstrøm, J. B., Sørensen, L. K., Kjolby, M., Gustavsen, S.
, Hansen, R. M., Petersen, T., Sellebjerg, F.
, Kasch, H., Rasmussen, P. V., Finnerup, N. B., Saedder, E. A. & Svendsen, K. B. (2024).
Pharmacokinetics and pharmacodynamics of cannabis-based medicine in a patient population included in a randomized, placebo-controlled, clinical trial.
Clinical and Translational Science,
17(1), Article e13685.
https://doi.org/10.1111/cts.13685
Breining, P., Pedersen, S. B., Kjolby, M., Hansen, J. B.
, Jessen, N. & Richelsen, B. (2021).
Parathyroid hormone receptor stimulation induces human adipocyte lipolysis and browning.
European Journal of Endocrinology,
184(5), 687-697.
https://doi.org/10.1530/EJE-20-0713
Andersen, O. M., Reiche, J., Schmidt, V., Gotthardt, M., Spoelgen, R., Behlke, J., von Arnim, C. A., Breiderhoff, T.
, Jansen, P., Wu, X., Bales, K. R., Cappai, R., Masters, C. L.
, Gliemann, J., Mufson, E. J., Hyman, B. T., Paul, S. M.
, Nykjær, A. & Willnow, T. E. (2005).
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Proceedings of the National Academy of Sciences (PNAS),
102(38), 13461-13466.
Evans, S. F., Irmady, K., Ostrow, K., Kim, T.
, Nykjaer, A., Saftig, P., Blobel, C. & Hempstead, B. L. (2011).
Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation.
Journal of Biological Chemistry,
286(34), 29556-67.
https://doi.org/10.1074/jbc.M111.219675
