Goettsch, C., Hutscheson, JD., Hagita, S., Rogers, M., Creager, MD., Pham, T., Choi, J., Mlynarchik, AK., Pieper, B.
, Kjølby, M. F., Aikawa, M. & Aikawa, E. (2016).
A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification. Atherosclerosis,
251, 109-118.
Klinger, S. C.
, Højland, A., Jain, S.
, Kjolby, M., Madsen, P., Svendsen, A. D., Olivecrona, G., Bonifacino, J. S.
& Nielsen, M. S. (2016).
Polarized Trafficking of the Sorting Receptor SorLA in Neurons and MDCK Cells.
F E B S Journal,
283(13), 2476–2493.
https://doi.org/10.1111/febs.13758
Molgaard, S., Demontis, D., Nicholson, A. M., Finch, N. A., Petersen, R. C.
, Petersen, C. M., Rademakers, R.
, Nykjaer, A. & Glerup, S. (2016).
Soluble sortilin is present in excess and positively correlates with progranulin in CSF of aging individuals.
Experimental Gerontology,
84, 96-100.
https://doi.org/10.1016/j.exger.2016.09.002
Goettsch, C., Hutscheson, JD., Aikawa, M., Iwata, H., Pham, T.
, Nykjær, A., Kjølby, M. F., Rogers, M., Michel, T., Shibasaki, M., Hagita, S., Kramann, R., Rader, D. J., Libby, P., Singh, SA. & Aikawa, E. (2016).
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. Journal of Clinical Investigation,
126(4), 1323.
Lisi, S.
, Madsen, P., Botta, R.
, Petersen, C. M., Nykjær, A., Latrofa, F., Vitti, P. & Marinò, M. (2015).
ABSENCE OF A THYROID PHENOTYPE IN SORTILIN-DEFICIENT MICE.
Endocrine Practice,
21(9), 981-985.
https://doi.org/10.4158/EP15697.OR
Steffensen, L. B.
, Mortensen, M. B., Kjolby, M., Hagensen, M. K.
, Oxvig, C. & Bentzon, J. F. (2015).
Disturbed Laminar Blood Flow Vastly Augments Lipoprotein Retention in the Artery Wall: A Key Mechanism Distinguishing Susceptible From Resistant Sites.
Arteriosclerosis, Thrombosis, and Vascular Biology,
35, 1928-1935.
https://doi.org/10.1161/ATVBAHA.115.305874
Bundgaard Christiansen, G., Breiderhoff, T.
, Nykjær, A., Jensen, K., Willnow, T.
& Holm, M. M. (2014).
Getting closer to the function of the postsynaptic receptor SORCS3 in synaptic transmission and synaptic plasticity. Abstract from 9th FENS forum of neuroscience , Milan, Italy.
Glerup, S., Olsen, D.
, Vægter, C. B., Gustafsen, C., Sjøgaard, S., Hermey, G.
, Kjølby, M. F., Jensen, S. M., Ulrichsen, M.
, Hansen, S. B., Skeldal, S., Fjorback, A. N.
, Nyengaard, J. R., Jacobsen, J.
, Bender, D., Bjarkam, C. R.
, Sørensen, E. S., Füchtbauer, E.-M., Eichele, G.
... Nykjær, A. (2014).
SorCS2 Regulates Dopaminergic Wiring and Is Processed into an Apoptotic Two-Chain Receptor in Peripheral Glia.
Neuron,
82(5), 1074–1087.
https://doi.org/10.1016/j.neuron.2014.04.022
Mortensen, M. B., Kjolby, M., Gunnersen, S., Larsen, J. V.
, Palmfeldt, J., Falk, E., Nykjaer, A. & Bentzon, J. F. (2014).
Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis.
Journal of Clinical Investigation,
124(12), 5317-5322.
https://doi.org/10.1172/JCI76002
Gustafsen, C., Kjolby, M., Nyegaard, M., Mattheisen, M., Lundhede, J.
, Buttenschøn, H., Mors, O., Bentzon, J. F., Madsen, P., Nykjaer, A. & Glerup, S. (2014).
The Hypercholesterolemia-Risk Gene SORT1 Facilitates PCSK9 Secretion.
Cell Metabolism,
19(2), 310-8.
https://doi.org/10.1016/j.cmet.2013.12.006
Cases, O., Perea-Gomez, A., P. Aguiar, D.
, Nykjær, A., Amsellem, S., Chandellier, J., Umbhauer, M., Cereghini, S.
, Madsen, M., Collignon, J., Verroust, P. J., Riou, J.-F., E. Creuzet, S. & Kozyraki, R. (2013).
Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head.
Journal of Biological Chemistry,
288(23), 16655-70.
https://doi.org/10.1074/jbc.M113.451070
Capsoni, S., Amato, G., Vignone, D., Criscuolo, C.
, Nykjaer, A. & Cattaneo, A. (2013).
Dissecting the role of sortilin receptor signaling in neurodegeneration induced by NGF deprivation.
Biochemical and Biophysical Research Communications,
431(3), 579-85.
https://doi.org/10.1016/j.bbrc.2013.01.007
Olsen, D., Kaas, M., Schwartz, O.
, Nykjaer, A. & Glerup, S. (2013).
Loss of BDNF or its receptors in three mouse models has unpredictable consequences for anxiety and fear acquisition.
Learning & Memory (Online),
20(9), 499-504.
https://doi.org/10.1101/lm.032045.113
Etzerodt, A., Kjolby, M., Nielsen, M. J., Maniecki, M. B.
, Svendsen, P. & Moestrup, S. K. (2013).
Plasma clearance of hemoglobin and haptoglobin in mice and effect of CD163 gene targeting disruption.
Antioxidants & Redox Signaling,
18(17), 2254-2263.
https://doi.org/10.1089/ars.2012.4605
Glerup, S., Lume, M., Olsen, D.
, Nyengaard, J. R., Vaegter, C. B., Gustafsen, C., Christensen, E. I., Kjolby, M., Hay-Schmidt, A.
, Bender, D., Madsen, P., Saarma, M.
, Nykjaer, A. & Petersen, C. M. (2013).
SorLA Controls Neurotrophic Activity by Sorting of GDNF and Its Receptors GFRα1 and RET.
Cell Reports,
3, 186-199.
https://doi.org/10.1016/j.celrep.2012.12.011
Burgert, T., Schmidt, V., Caglayan, S., Lin, F.
, Füchtbauer, A., Füchtbauer, E.-M., Nykjaer, A., Carlo, A.-S. & Willnow, T. E. (2013).
SORLA-Dependent and -Independent Functions for PACS1 in Control of Amyloidogenic Processes.
Molecular and Cellular Biology,
33(21), 4308-4320.
https://doi.org/10.1128/MCB.00628-13
Gustafsen, C., Glerup, S., Pallesen, L. T., Olsen, D.
, Andersen, O. M., Nykjær, A., Madsen, P. & Petersen, C. M. (2013).
Sortilin and SorLA Display Distinct Roles in Processing and Trafficking of Amyloid Precursor Protein.
Journal of Neuroscience,
33(1), 64-71.
https://doi.org/10.1523/JNEUROSCI.2371-12.2013
Breiderhoff, T.
, Christiansen, G. B., Pallesen, L. T., Vægter, C. B., Nykjaer, A., Holm, M. M., Glerup, S. & Willnow, T. E. (2013).
Sortilin-Related Receptor SORCS3 Is a Postsynaptic Modulator of Synaptic Depression and Fear Extinction.
PLOS ONE,
8(9), e75006.
https://doi.org/10.1371/journal.pone.0075006
Carlo, A.-S.
, Gustafsen, C., Mastrobuoni, G.
, Nielsen, M. S., Burgert, T., Hartl, D., Rohe, M.
, Nykjaer, A., Herz, J., Heeren, J., Kempa, S.
, Petersen, C. M. & Willnow, T. E. (2013).
The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid-β Peptide in the Brain.
Journal of Neuroscience,
33(1), 358-70.
https://doi.org/10.1523/JNEUROSCI.2425-12.2013
Skeldal, S., Sykes, A. M.
, Glerup, S., Matusica, D., Palstra, N., Autio, H., Boskovic, Z.
, Madsen, P., Castrén, E.
, Nykjaer, A. & Coulson, E. J. (2012).
Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis.
Journal of Biological Chemistry,
287(52), 43798-809.
https://doi.org/10.1074/jbc.M112.374710
Gass, J., Lee, W. C., Cook, C., Finch, N., Stetler, C., Jansen-West, K., Lewis, J., Link, C. D., Rademakers, R.
, Nykjær, A. & Petrucelli, L. (2012).
Progranulin regulates neuronal outgrowth independent of Sortilin.
Molecular Neurodegeneration,
7, 33.
https://doi.org/10.1186/1750-1326-7-33
Siao, C.-J., Lorentz, C. U., Kermani, P., Marinic, T., Carter, J. D., McGrath, K., Padow, V. A., Mark, W., Falcone, D. J., Cohen-Gould, L., Parrish, D. C., Habecker, B. A.
, Nykjaer, A., Ellenson, L. H., Tessarollo, L. & Hempstead, B. L. (2012).
ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation.
The Tohoku Journal of Experimental Medicine,
209(12), 2291-305.
https://doi.org/10.1084/jem.20111749
Schmidt, V., Baum, K., Lao, A., Rateitschak, K., Schmitz, Y., Teichmann, A., Wiesner, B.
, Petersen, C. M., Nykjaer, A., Wolf, J., Wolkenhauer, O. & Willnow, T. E. (2012).
Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease.
E M B O Journal,
31(1), 187-200.
https://doi.org/10.1038/emboj.2011.352
Fjorback, A. W., Seaman, M.
, Gustafsen, C., Mehmedbasic, A., Gokool, S., Wu, C., Militz, D., Schmidt, V.
, Madsen, P., Nyengaard, J. R., E Willnow, T.
, Christensen, E. I., B Mobley, W.
, Nykjær, A. & Andersen, O. M. (2012).
Retromer Binds the FANSHY Sorting Motif in SorLA to Regulate Amyloid Precursor Protein Sorting and Processing.
Journal of Neuroscience,
32(4), 1467-1480.
https://doi.org/10.1523/JNEUROSCI.2272-11.2012
Klinger, S. C.
, Højland, A., Gustafsen, C., Glerup, S., Kjølby, M. F., Helms, H. C., Raarup, M. K., Olivecrona, G., Brodin, B.
, Petersen, C. M., Nykjær, A. & Nielsen, M. S. (2012).
SorLA regulates trafficking of Lipoprotein Lipase in polarized cells and astrocytes. Poster session presented at Barriers of the CNS, New London NH, United States.
Richner, M., Bjerrum, O. J., Koninck, Y. D.
, Nykjaer, A. & Vaegter, C. B. (2012).
Sortilins in neuropathic pain.
Scandinavian Journal of Pain,
3(3), 183-183.
https://doi.org/10.1016/j.sjpain.2012.05.028
Shulga, A., Magalhães, A. C., Autio, H., Plantman, S., di Lieto, A.
, Nykjær, A., Carlstedt, T., Risling, M., Arumäe, U., Castrén, E. & Rivera, C. (2012).
The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons.
Journal of Neuroscience,
32(5), 1757-70.
https://doi.org/10.1523/JNEUROSCI.3282-11.2012
Dinet, V., An, N., Ciccotosto, G. D., Bruban, J., Maoui, A., Bellingham, S. A., Hill, A. F.
, Andersen, O. M., Nykjaer, A., Jonet, L., Cappai, R. & Mascarelli, F. (2011).
APP involvement in retinogenesis of mice.
Acta Neuropathologica,
121(3), 351-63.
https://doi.org/10.1007/s00401-010-0762-2
Sørensen, M. V., Prætorius, H., Nykjær, A., Willnow, T.
& Leipziger, J. G. (2011).
Impaired aldosterone responsiveness in corticosteroid deficient mice. Acta Physiologica (Print),
201, 169-177.
Evans, S. F., Irmady, K., Ostrow, K., Kim, T.
, Nykjaer, A., Saftig, P., Blobel, C. & Hempstead, B. L. (2011).
Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation.
Journal of Biological Chemistry,
286(34), 29556-67.
https://doi.org/10.1074/jbc.M111.219675
Tauris, J.
, Gustafsen, C., Christensen, E. I., Jansen, P.
, Nykjaer, A., Nyengaard, J. R., Teng, K. K., Schwarz, E.
, Ovesen, T., Madsen, P. & Petersen, C. M. (2011).
Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons.
European Journal of Neuroscience,
33, 622-631.
https://doi.org/10.1111/j.1460-9568.2010.07556.x
Klinger, S. C.
, Glerup, S., Raarup, M. K., Mari, MC., Nyegaard, M., Koster, G.
, Prabakaran, T., Nilsson, SK., Kjærgaard, M. M., Bakke, O.
, Nykjær, A., Olivecrona, G.
, Petersen, C. M. & Nielsen, MS. (2011).
SorLA regulates lipoprotein lipase activity by intracellular trafficking. Poster session presented at PhD Day 2011, Aarhus University, Faculty of Health Sciences, Aarhus, Denmark.
Klinger, S. C.
, Glerup, S., Raarup, M. K., Mari, MC., Nyegaard, M., Koster, G.
, Prabakaran, T., Nilsson, SK., Kjærgaard, M. M., Bakke, O.
, Nykjær, A., Olivecrona, G.
, Petersen, C. M. & Nielsen, MS. (2011).
SorLA regulates lipoprotein lipase activity by intracellular trafficking. Abstract from PhD Day 2011, Aarhus University, Faculty of Health Sciences, Aarhus, Denmark.
Klinger, S. C.
, Glerup, S., Raarup, M. K., Mari, M. C., Nyegaard, M., Koster, G.
, Prabakaran, T., Nilsson, B. S., Kjaergaard, M. M., Bakke, O.
, Nykjær, A., Olivecrona, G.
, Petersen, C. M. & Nielsen, M. S. (2011).
SorLA regulates the activity of lipoprotein lipase by intracellular trafficking.
Journal of Cell Science,
124(Pt 7), 1095-105.
https://doi.org/10.1242/jcs.072538
Vaegter, C. B., Jansen, P., Fjorback, A. W.
, Glerup, S., Skeldal, S.
, Kjølby, M. F., Richner, M., Erdmann, B.
, Nyengaard, J. R., Tessarollo, L., Lewin, G. R., Willnow, T. E., Chao, M. V.
& Nykjaer, A. (2011).
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.
Nature Neuroscience,
14(1), 54-61.
https://doi.org/10.1038/nn.2689
Wähe, A., Kasmapour, B., Schmaderer, C., Liebl, D., Sandhoff, K.
, Nykjaer, A., Griffiths, G. & Gutierrez, M. G. (2010).
Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin.
Journal of Cell Science,
123(Pt 14), 2502-11.
https://doi.org/10.1242/jcs.067686