Pallesen, L. T., Gustafsen, C., Cramer, J., Petersen, S. V., Thirup, S. S., Madsen, P. & Petersen, C. M. (2020).
PAK kinases targets sortilin and modulates its sorting.
Molecular and Cellular Biology,
40(3), Article e00411-19.
https://doi.org/10.1128/MCB.00411-19
Januliene, D., Andersen, J. L., Nielsen, J. A., Quistgaard, E. M., Hansen, M., Strandbygaard, D., Moeller, A.
, Petersen, C. M., Madsen, P. & Thirup, S. S. (2017).
Acidic Environment Induces Dimerization and Ligand Binding Site Collapse in the Vps10p Domain of Sortilin.
Structure,
25(12), 1809-1819.e3. Article 12.
https://doi.org/10.1016/j.str.2017.09.015
Larsen, J. V., Kristensen, A. M., Pallesen, L. T., Bauer, J., Vægter, C. B., Nielsen, M. S., Madsen, P. & Petersen, C. M. (2016).
Cytokine-like factor-1 (CLF-1): An essential facilitator of cardiotrophin-like cytokine: CNTFRα (CLC:CNTFRα) signalling and sorLA mediated turnover.
Molecular and Cellular Biology,
36(8), 1272-1286.
https://doi.org/10.1128/mcb.00917-15
Molgaard, S., Demontis, D., Nicholson, A. M., Finch, N. A., Petersen, R. C.
, Petersen, C. M., Rademakers, R.
, Nykjaer, A. & Glerup, S. (2016).
Soluble sortilin is present in excess and positively correlates with progranulin in CSF of aging individuals.
Experimental Gerontology,
84, 96-100.
https://doi.org/10.1016/j.exger.2016.09.002
Lisi, S.
, Madsen, P., Botta, R.
, Petersen, C. M., Nykjær, A., Latrofa, F., Vitti, P. & Marinò, M. (2015).
ABSENCE OF A THYROID PHENOTYPE IN SORTILIN-DEFICIENT MICE.
Endocrine Practice,
21(9), 981-985.
https://doi.org/10.4158/EP15697.ORButtenschøn, H. N., Demontis, D., Ollendorff, M. K., Elfving, B., Jensen, S. M., Gustafsen, C., Kærlev, L.
, Petersen, C. M., Børglum, A., Mors, O. & Pedersen, S. G. (2015).
Increased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF.
Translational Psychiatry,
5(e677).
https://doi.org/10.1038/tp.2015.167
Buttenschøn, H. N., Demontis, D., Kaas, M.
, Elfving, B., mølgaard, S.
, Gustafsen, C., Kærlev, L.
, Petersen, C. M., Børglum, A., Mors, O.
& Pedersen, S. G. (2015).
Increased sortilin in depression.
Larsen, J. V., Hermey, G., Sørensen, E. S., Prabakaran, T., Christensen, E. I., Gliemann, J., Madsen, P. & Petersen, C. M. (2014).
Human sorCS1 binds sortilin and hampers its cellular functions.
Biochemical Journal,
457(2), 277–288.
https://doi.org/10.1042/BJ20130386
Quistgaard, E. M., Grøftehauge, M. K., Madsen, P., Pallesen, L. T., Christensen, B. S., Sørensen, E. S., Nissen, P., Petersen, C. M. & Thirup, S. S. (2014).
Revisiting the structure of the Vps10 domain of human sortilin and its interaction with neurotensin.
Protein Science,
23(9), 1291-1300.
https://doi.org/10.1002/pro.2512
Glerup, S., Olsen, D., Vægter, C. B., Gustafsen, C., Sjøgaard, S., Hermey, G., Kjølby, M. F., Jensen, S. M., Ulrichsen, M., Hansen, S. B., Skeldal, S.
, Fjorback, A. N., Nyengaard, J. R., Jacobsen, J.
, Bender, D., Bjarkam, C. R.
, Sørensen, E. S., Füchtbauer, E.-M., Eichele, G.
... Nykjær, A. (2014).
SorCS2 Regulates Dopaminergic Wiring and Is Processed into an Apoptotic Two-Chain Receptor in Peripheral Glia.
Neuron,
82(5), 1074–1087.
https://doi.org/10.1016/j.neuron.2014.04.022
Baltes, J.
, Larsen, J. V., Radhakrishnan, K., Geumann, C., Kratzke, M.
, Petersen, C. M. & Schu, P. (2014).
σ1B adaptin regulates adipogenesis by mediating the sorting of sortilin in adipose tissue.
Journal of Cell Science,
127(Pt 16), 3477-87.
https://doi.org/10.1242/jcs.146886Glerup, S., Lume, M.
, Olsen, D., Nyengaard, J. R., Vaegter, C. B., Gustafsen, C., Christensen, E. I., Kjolby, M., Hay-Schmidt, A.
, Bender, D., Madsen, P., Saarma, M.
, Nykjaer, A. & Petersen, C. M. (2013).
SorLA Controls Neurotrophic Activity by Sorting of GDNF and Its Receptors GFRα1 and RET.
Cell Reports,
3, 186-199.
https://doi.org/10.1016/j.celrep.2012.12.011
Gustafsen, C., Glerup, S., Pallesen, L. T., Olsen, D., Andersen, O. M., Nykjær, A., Madsen, P. & Petersen, C. M. (2013).
Sortilin and SorLA Display Distinct Roles in Processing and Trafficking of Amyloid Precursor Protein.
Journal of Neuroscience,
33(1), 64-71.
https://doi.org/10.1523/JNEUROSCI.2371-12.2013
Carlo, A.-S.
, Gustafsen, C., Mastrobuoni, G.
, Nielsen, M. S., Burgert, T., Hartl, D., Rohe, M.
, Nykjaer, A., Herz, J., Heeren, J., Kempa, S.
, Petersen, C. M. & Willnow, T. E. (2013).
The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid-β Peptide in the Brain.
Journal of Neuroscience,
33(1), 358-70.
https://doi.org/10.1523/JNEUROSCI.2425-12.2013Schmidt, V., Baum, K., Lao, A., Rateitschak, K., Schmitz, Y., Teichmann, A., Wiesner, B.
, Petersen, C. M., Nykjaer, A., Wolf, J., Wolkenhauer, O. & Willnow, T. E. (2012).
Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease.
E M B O Journal,
31(1), 187-200.
https://doi.org/10.1038/emboj.2011.352Klinger, S. C., Højland, A., Gustafsen, C., Glerup, S., Kjølby, M. F., Helms, H. C.
, Raarup, M. K., Olivecrona, G., Brodin, B.
, Petersen, C. M., Nykjær, A. & Nielsen, M. S. (2012).
SorLA regulates trafficking of Lipoprotein Lipase in polarized cells and astrocytes. Poster session presented at Barriers of the CNS, New London NH, United States.
Tauris, J., Gustafsen, C., Christensen, E. I., Jansen, P., Nykjaer, A., Nyengaard, J. R., Teng, K. K., Schwarz, E.
, Ovesen, T., Madsen, P. & Petersen, C. M. (2011).
Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons.
European Journal of Neuroscience,
33, 622-631.
https://doi.org/10.1111/j.1460-9568.2010.07556.x
Prabakaran, T., Nielsen, R., Larsen, J. V., Sørensen, S. S., Rasmussen, U. F., Saleem, M. A.
, Petersen, C. M., Verroust, P. J. & Christensen, E. I. (2011).
Receptor-Mediated Endocytosis of α-Galactosidase A in Human Podocytes in Fabry Disease.
PLoS One,
6(9), e25065.
https://doi.org/10.1371/journal.pone.0025065
Klinger, S. C., Glerup, S., Raarup, M. K., Mari, MC.
, Nyegaard, M., Koster, G.
, Prabakaran, T., Nilsson, SK.
, Kjærgaard, M. M., Bakke, O.
, Nykjær, A., Olivecrona, G.
, Petersen, C. M. & Nielsen, MS. (2011).
SorLA regulates lipoprotein lipase activity by intracellular trafficking. Poster session presented at PhD Day 2011, Aarhus University, Faculty of Health Sciences, Aarhus, Denmark.
Klinger, S. C., Glerup, S., Raarup, M. K., Mari, MC.
, Nyegaard, M., Koster, G.
, Prabakaran, T., Nilsson, SK.
, Kjærgaard, M. M., Bakke, O.
, Nykjær, A., Olivecrona, G.
, Petersen, C. M. & Nielsen, MS. (2011).
SorLA regulates lipoprotein lipase activity by intracellular trafficking. Abstract from PhD Day 2011, Aarhus University, Faculty of Health Sciences, Aarhus, Denmark.
Klinger, S. C., Glerup, S., Raarup, M. K., Mari, M. C.
, Nyegaard, M., Koster, G.
, Prabakaran, T., Nilsson, B. S.
, Kjaergaard, M. M., Bakke, O.
, Nykjær, A., Olivecrona, G.
, Petersen, C. M. & Nielsen, M. S. (2011).
SorLA regulates the activity of lipoprotein lipase by intracellular trafficking.
Journal of Cell Science,
124(Pt 7), 1095-105.
https://doi.org/10.1242/jcs.072538
Thirup, S. S., Grøftehauge, M. K., Madsen, P. S., Petersen, C. M., Nissen, P., Quistgaard, E. M. H., Andersen, J. L. & Cramer, J. F. (2010).
Design and use of Sortilin specific molecular imaging ligands. (Patent No.
PA 2008 00593).
Thirup, S. S., Petersen, C. M., Quistgaard, E. M. H., Madsen, P. S., Nissen, P., Grøftehauge, M. K., Cramer, J. F. & Andersen, J. L. (2010).
Design of specific ligands to Sortilin. (Patent No.
PA 2008 00592).
Cramer, J. F., Gustafsen, C., Behrens, M. A., Oliveira, C. L. P., Pedersen, J. S., Madsen, P., Petersen, C. M. & Thirup, S. S. (2010).
GGA autoinhibition revisited.
Traffic,
11(2), 259-73.
https://doi.org/10.1111/j.1600-0854.2009.01017.x
Larsen, J. V., Hansen, M., Møller, B. K., Madsen, P. S., Scheller, J.
, Nielsen, M. S. & Petersen, C. M. (2010).
Sortilin Facilitates Signaling of Ciliary Neurotrophic Factor and Related Helical Type 1 Cytokines Targeting the gp130/Leukemia Inhibitory Factor Receptor β Heteromer.
Molecular and Cellular Biology,
30(17), 4175-4187.
Tauris, J., Christensen, E. I., Nykjær, A., Jacobsen, C., Petersen, C. M. & Ovesen, T. (2009).
Cubilin and Megalin Co-Localize in the Neonatal Inner Ear.
Audiology and Neuro-Otology,
14(4), 267-278.
https://doi.org/10.1159/000199446
Quistgaard, E. M., Madsen, P., Grøftehauge, M. K., Nissen, P., Petersen, C. M. & Thirup, S. S. (2009).
Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain.
Nature Structural and Molecular Biology,
16(1), 96-8.
https://doi.org/10.1038/nsmb.1543
Botta, R., Lisi, S., Pinchera, A., Giorgo, F., Marcossi, C., Taddei, A. R., Fausto, A. M., Bernardini, N., Ippolito, C., Mattii, L., Persani, L., Filippis, T. D., Calebiro, D.
, Madsen, P. S., Petersen, C. M. & Marino, M. (2009).
Sortilin is a putative post-endocytic receptor of thyroglobulin.
Endocrinology, (150), 509-518.
Gustafsen, C., Tauris, J., Christensen, E. I., Jansen, P., Nykjær, A., Teng, K. K., Schwarz, E.
, Madsen, P. S. & Petersen, C. M. (2009).
The neurotrophin precursor proNT-3 promotes Sortilin:p75NTR complex formation and induces apoptosis. Poster session presented at Society for Neuroscience 2009, Chicago, United States.
Mari, M., Bujny, M. V., Zeuschner, D., Geerts, W. J. C., Griffith, J.
, Petersen, C. M., Cullen, P. J., Klumperman, J. & Geuze, H. J. (2008).
SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors.
Traffic,
9(3), 380-93.
https://doi.org/10.1111/j.1600-0854.2007.00686.x
Mari, M., Bujny, M. V., Zeuschnet, D., Geerts, W. J. C., Griffith, J.
, Petersen, C. M., Cullen, P. J., Klumperman, J. & Geuze, H. J. (2008).
SNZX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors.
Traffic,
8, 380-393.
Jansen, P., Giehl, K., Nyengaard, J. R., Teng, K., Lioubinski, O.
, Sjoegaard, S. S., Breiderhoff, T., Gotthardt, M.
, Lin, F., Eilers, A.
, Petersen, C. M., Lewin, G. R., Hempstead, B. L., Willnow, T. E.
& Nykjaer, A. (2007).
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nature Neuroscience,
10(11), 1449-57.
https://doi.org/10.1038/nn2000
Nielsen, M. S., Gustafsen, C., Madsen, P., Nyengaard, J. R., Hermey, G., Bakke, O., Mari, M., Schu, P., Pohlmann, R., Dennes, A.
& Petersen, C. M. (2007).
Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA. Molecular and Cellular Biology,
27(19), 6842-51.
https://doi.org/10.1128/MCB.00815-07
Gustafsen, C., Nielsen, M. S., Madsen, P. S., Dennes, A., Schu, P.
& Petersen, C. M. (2006).
The APP binding receptor SorLA mediates Golgi-endosome shuttling. Poster session presented at EMBO research conference on Interface of Cell Biology and Cellular Microbiology. Macromolecular Complexes in Microbial Pathogenesis, Membrane Trafficking and Cell Signalling, San Feliu de Guixols, Spain.
Hermey, G., Sjøgaard, S., Petersen, C. M., Nykjær, A. & Gliemann, J. (2006).
Tumour necrosis factor-α convertase mediates ectodomain shedding of Vps10p-domain receptor family members.
Biochemical Journal,
395(2), 285-293.
Westergaard, U. B.
, Kirkegaard, K., Sørensen, E. S., Jacobsen, C., Nielsen, M. S., Pedersen, J. C. M. & Madsen, P. S. (2005).
SorCS3 does not require propeptide cleavage to bind nerve growth factor.
FEBS Letters,
579(5), 1172-1176.
Westergaard, U. B.
, Sørensen, E. S., Hermey, G.
, Nielsen, M. S., Nykjær, A., Kirkegaard, K., Jacobsen, C., Gliemann, J., Madsen, P. S. & Pedersen, J. C. M. (2004).
Functional organization of the sortilin Vps10p domain.
Journal of Biological Chemistry,
279, 50221-50229.
Nykjær, A., Lee, R., Teng, K. K.
, Jansen, P., Madsen, P. S., Nielsen, M. S., Jacobsen, C., Kliemannel, M., Schwarz, E., Willnow, T. E., Hempstead, B. L.
& Pedersen, J. C. M. (2004).
Sortilin is essential for proNGF-induced neuronal cell death.
Nature,
427, 843-848.
Gliemann, J., Hermey, G.
, Nykjær, A., Pedersen, J. C. M., Jacobsen, C. & Andreasen, P. A. (2004).
The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand. Biochemical Journal,
381, 203-212.
Hermey, G., Keat, S. J.
, Madsen, P. S., Jacobsen, C., Pedersen, J. C. M. & Gliemann, J. (2003).
Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells.
Journal of Biological Chemistry, (278), 7390-7396.
Sarret, P., Krzykowski, P., Segal, L.
, Nielsen, M. S., Pedersen, J. C. M., Mazella, J., Stroh, T. & Beaudet, A. (2003).
Distribution of NTS3 receptor/sortilin mRNA and protein in the rat central nervous system.
J. Comp. Neurol., (461), 483-505.
Conticello, S. G., Kowalsman, N. D.
, Jacobsen, C., Yudkovsky, G., Sato, K., Elazar, Z.
, Pedersen, J. C. M., Aronheim, A. & Fainzilber, M. (2003).
The prodomain of a secreted hydrophobic mini-protein facilitates its export from the endoplasmic reticulum by hitchhiking on sorting receptors.
Journal of Biological Chemistry, (278), 26311-26314.
Jacobsen, L.
, Madsen, P. S., Nielsen, M. S., Geraerts, W. P. M.
, Gliemann, J., Smit, A. B.
& Pedersen, J. C. M. (2002).
The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding.
FEBS Letters,
511(1-3), 155-158.
