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The Endo-Lysosomal System of Brain Endothelial Cells Is Influenced by Astrocytes In Vitro.
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Cytokine-like factor-1 (CLF-1): An essential facilitator of cardiotrophin-like cytokine: CNTFRα (CLC:CNTFRα) signalling and sorLA mediated turnover.
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Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease.
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SorCS2 Regulates Dopaminergic Wiring and Is Processed into an Apoptotic Two-Chain Receptor in Peripheral Glia.
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The Hypercholesterolemia-Risk Gene SORT1 Facilitates PCSK9 Secretion.
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SorLA Controls Neurotrophic Activity by Sorting of GDNF and Its Receptors GFRα1 and RET.
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Sortilin and SorLA Display Distinct Roles in Processing and Trafficking of Amyloid Precursor Protein.
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Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis.
Journal of Biological Chemistry,
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Retromer Binds the FANSHY Sorting Motif in SorLA to Regulate Amyloid Precursor Protein Sorting and Processing.
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The C-terminal proteolytic processing of extracellular superoxide dismutase is redox regulated.
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Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons.
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Sortilin Facilitates Signaling of Ciliary Neurotrophic Factor and Related Helical Type 1 Cytokines Targeting the gp130/Leukemia Inhibitory Factor Receptor β Heteromer.
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Sortilin is a putative post-endocytic receptor of thyroglobulin.
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The neurotrophin precursor proNT-3 promotes Sortilin:p75NTR complex formation and induces apoptosis. Poster session presented at Society for Neuroscience 2009, Chicago, United States.
Hauburger, A., Kliemannel, M.
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Oxidative folding of nerve growth factor can be mediated by the pro-peptide of neurotrophin-3.
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Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA. Molecular and Cellular Biology,
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The APP binding receptor SorLA mediates Golgi-endosome shuttling. Poster session presented at EMBO research conference on Interface of Cell Biology and Cellular Microbiology. Macromolecular Complexes in Microbial Pathogenesis, Membrane Trafficking and Cell Signalling, San Feliu de Guixols, Spain.
Lindersson, E.
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P25a stimulate α-synuclein aggregation and is colocalized with aggregated α-synuclein in α-synucleinopathies.
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p25α Stimulates α-Synuclein Aggregation and Is Co-localized with Aggregated α-Synuclein in α-Synucleinopathies.
Journal of Biological Chemistry,
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SorCS3 does not require propeptide cleavage to bind nerve growth factor.
FEBS Letters,
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Westergaard, U. B.
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Functional organization of the sortilin Vps10p domain.
Journal of Biological Chemistry,
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Sortilin is essential for proNGF-induced neuronal cell death.
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Characterization of sorCS1, an alternatively spliced receptor with completely different cytoplasmic domains that mediate different trafficking in cells.
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Jacobsen, L.
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The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding.
FEBS Letters,
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Dennes, A.
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The Yeast Vps10p Cytoplasmic Tail Mediates Lysosomal Sorting in Mammalian Cells and Interacts with Human GGAs.
Journal of Biological Chemistry,
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Jacobsen, L.
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Activation and functional characterization of the mosaic receptor SorLA/LR11.
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The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein.
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Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding.
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EF-hands at atomic resolution: The structure of human psoriasin (S100A7) solved by MAD phasing.
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The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin.
FEBS Letters,
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