Publications

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Willnow, T. E. & Nykjær, A. (2002). Pathways for kidney-specific uptake of the steroid hormone 25-hydroxyvitamin D3. Curr Opin Lipidol, 13(3), 255-260.

Willnow, T. E. & Nykjær, A. (2004). Endocytic Pathways for 25-(OH) Vitamin D3. Elsevier Academic Press, 153-166.

Willnow, T. E. & Nykjær, A. (2006). Response: cellular uptake of ex steroid hormones. Cell, 124, 456-457.

Willnow, T. E., Hammes, A. & Nykjær, A. (2008). Endocytosis of sex stereoids: The hypothesis of free hormones revisited. Annales d'Endocrinologie, 69, 101-2.

Willnow, T. E., Petersen, C. M. & Nykjær, A. (2008). VPs10p-domain receptors . central regulators of neuronal viability. Nature Reviews. Neuroscience, 9, 899-909.

Willnow, T., Kjølby, M. F. & Nykjær, A. (2011). Sortilins: new players in lipoprotein metabolism. Current Opinion in Lipidology, 22(2), 79-85. https://doi.org/10.1097/MOL.0b013e3283416f2b

Willnow, T. E. & Nykjaer, A. (2010). Cellular uptake of steroid carrier proteins--mechanisms and implications. Molecular and Cellular Endocrinology, 316(1), 93-102. https://doi.org/10.1016/j.mce.2009.07.021

Westergaard, U. B., Sørensen, E. S., Hermey, G., Nielsen, M. S., Nykjær, A., Kirkegaard, K., Jacobsen, C., Gliemann, J., Madsen, P. S. & Pedersen, J. C. M. (2004). Functional organization of the sortilin Vps10p domain. Journal of Biological Chemistry, 279, 50221-50229.

Wähe, A., Kasmapour, B., Schmaderer, C., Liebl, D., Sandhoff, K., Nykjaer, A., Griffiths, G. & Gutierrez, M. G. (2010). Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin. Journal of Cell Science, 123(Pt 14), 2502-11. https://doi.org/10.1242/jcs.067686

Vardya, I., Holm, M. M., Dósa, Z., Nieto-Gonzalez, J. L., Nykjær, A. & Jensen, K. (2010). Increased synaptic GABAergic inhibition in dentate gyrus of mice deficient of sortilin. Joint meeting of the Scandinavian and German Physiological Societies Mar. 27 2010 - Mar. 30 2010 Copenhagen, Denmark. Poster session presented at Joint meeting of the Scandinavian and German physiological societies, Copenhagen, Denmark.

Vægter, C. B., Jansen, P., Erdmann, B., WillNow, T., Lewin, G., Tessarollo, L. & Nykjær, A. (2008). Sortilin positively modulates survival signaling by mature neurotrophins. Poster session presented at Society for Neuroscience 38th Annual Meeting, Washington, United States.

Vaegter, C. B., Jansen, P., Fjorback, A. W., Glerup, S., Skeldal, S., Kjølby, M. F., Richner, M., Erdmann, B., Nyengaard, J. R., Tessarollo, L., Lewin, G. R., Willnow, T. E., Chao, M. V. & Nykjaer, A. (2011). Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nature Neuroscience, 14(1), 54-61. https://doi.org/10.1038/nn.2689

Ulrichsen, M., Gonçalves, N. P., Mohseni, S., Hjæresen, S., Lisle, T. L., Molgaard, S., Madsen, N. K., Andersen, O. M., Svenningsen, Å. F., Glerup, S., Nykjær, A. & Vægter, C. B. (2022). Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve Injury. Frontiers in Cellular Neuroscience, 16, Article 856734. https://doi.org/10.3389/fncel.2022.856734

Uchiyama, K., Tomita, M., Yano, M., Chida, J., Hara, H., Das, N. R., Nykjaer, A. & Sakaguchi, S. (2017). Prions amplify through degradation of the VPS10P sorting receptor sortilin. PLoS Pathogens, 13(6), e1006470. Article e1006470. https://doi.org/10.1371/journal.ppat.1006470

Thomasen, P. B., Salasova, A., Kjaer-Sorensen, K., Woloszczuková, L., Lavický, J., Login, H., Tranberg-Jensen, J., Almeida, S., Beel, S., Kavková, M., Qvist, P., Kjolby, M., Ovesen, P. L., Nolte, S., Vestergaard, B., Udrea, A.-C., Nejsum, L. N., Chao, M. V., Van Damme, P. ... Nykjaer, A. (2023). SorCS2 binds progranulin to regulate motor neuron development. Cell Reports, 42(11), Article 113333. https://doi.org/10.1016/j.celrep.2023.113333

Teng, H. K., Teng, K. K., Lee, R., Wright, S., Tevar, S., Almeida, R. D., Kermani, P., Torkin, R., Chen, Z. Y., Lee, F. S., Kraemer, R. T., Nykjær, A. & Hempstead, B. L. (2005). ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75^NTR and sortilin. Journal of Neuroscience, 25, 5455-5463.

Tauris, J., Christensen, E. I., Nykjær, A., Jacobsen, C., Petersen, C. M. & Ovesen, T. (2009). Cubilin and Megalin Co-Localize in the Neonatal Inner Ear. Audiology and Neuro-Otology, 14(4), 267-278. https://doi.org/10.1159/000199446

Tauris, J., Gustafsen, C., Christensen, E. I., Jansen, P., Nykjaer, A., Nyengaard, J. R., Teng, K. K., Schwarz, E., Ovesen, T., Madsen, P. & Petersen, C. M. (2011). Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons. European Journal of Neuroscience, 33, 622-631. https://doi.org/10.1111/j.1460-9568.2010.07556.x

Steffensen, L. B., Mortensen, M. B., Kjolby, M., Hagensen, M. K., Oxvig, C. & Bentzon, J. F. (2015). Disturbed Laminar Blood Flow Vastly Augments Lipoprotein Retention in the Artery Wall: A Key Mechanism Distinguishing Susceptible From Resistant Sites. Arteriosclerosis, Thrombosis, and Vascular Biology, 35, 1928-1935. https://doi.org/10.1161/ATVBAHA.115.305874

Staehr, C., Login, H., Postnov, D., Berenji Ardestani, S., Nolte, S. S., Beck, H. C., Nykjær, A. & Matchkov, V. (2023). SorCS2 modulates neurovascular coupling via glutamatergic and calcium signaling in astrocytes. bioRxiv. https://doi.org/10.1101/2023.02.16.528727

Staehr, C., Login, H., Melnikova, E., Bakun, M., Ziemlinska, E., Kisiswa, L., Berenji Ardestani, S., Nolte, S. S., Beck, H. C., Hansen, L. M. B., Postnov, D., Verkhratsky, A., Malik, A. R., Nykjær, A. & Matchkov, V. (2025). SorCS2 Is Important for Astrocytic Function in Neurovascular Signaling. Acta Physiologica (Print), 241(6), Article e70052. https://doi.org/10.1111/apha.70052

Sørensen, M. V., Prætorius, H., Nykjær, A., Willnow, T. & Leipziger, J. G. (2011). Impaired aldosterone responsiveness in corticosteroid deficient mice. Acta Physiologica (Print), 201, 169-177.

Sørensen, L. K., Hasselstrøm, J. B., Damsgaard Gunst, J., Søgaard, O. S. & Kjolby, M. (2021). Determination of camostat and its metabolites in human plasma – Preservation of samples and quantification by a validated UHPLC-MS/ MS method. Clinical Biochemistry, 96, 56-62. https://doi.org/10.1016/j.clinbiochem.2021.07.007

Smith, A. H., Ovesen, P. L., Skeldal, S., Yeo, S., Jensen, K. P., Olsen, D., Diazgranados, N., Zhao, H., Farrer, L. A., Goldman, D., Glerup, S., Kranzler, H. R., Nykjaer, A. & Gelernter, J. (2018). Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2. Alcoholism: Clinical and Experimental Research, 42(12), 2337-2348. https://doi.org/10.1111/acer.13890

Skeldal, S., Matusica, D., Nykjaer, A. & Coulson, E. J. (2011). Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR). BioEssays, 33(8), 614-25. https://doi.org/10.1002/bies.201100036

Skeldal, S., Sykes, A. M., Glerup, S., Matusica, D., Palstra, N., Autio, H., Boskovic, Z., Madsen, P., Castrén, E., Nykjaer, A. & Coulson, E. J. (2012). Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis. Journal of Biological Chemistry, 287(52), 43798-809. https://doi.org/10.1074/jbc.M112.374710

Siao, C.-J., Lorentz, C. U., Kermani, P., Marinic, T., Carter, J. D., McGrath, K., Padow, V. A., Mark, W., Falcone, D. J., Cohen-Gould, L., Parrish, D. C., Habecker, B. A., Nykjaer, A., Ellenson, L. H., Tessarollo, L. & Hempstead, B. L. (2012). ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation. The Tohoku Journal of Experimental Medicine, 209(12), 2291-305. https://doi.org/10.1084/jem.20111749

Shulga, A., Magalhães, A. C., Autio, H., Plantman, S., di Lieto, A., Nykjær, A., Carlstedt, T., Risling, M., Arumäe, U., Castrén, E. & Rivera, C. (2012). The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons. Journal of Neuroscience, 32(5), 1757-70. https://doi.org/10.1523/JNEUROSCI.3282-11.2012

Shrestha, M., Bai, Z., Gholipourshahraki, T., Hjelholt, A. J., Hu, S., Kjolby, M., Rohde, P. D. & Sørensen, P. (2025). Enhanced genetic fine mapping accuracy with Bayesian Linear Regression models in diverse genetic architectures. PLoS Genetics, 21(7), e1011783. Article e1011783. https://doi.org/10.1371/journal.pgen.1011783

Schmidt, V., Baum, K., Lao, A., Rateitschak, K., Schmitz, Y., Teichmann, A., Wiesner, B., Petersen, C. M., Nykjaer, A., Wolf, J., Wolkenhauer, O. & Willnow, T. E. (2012). Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease. E M B O Journal, 31(1), 187-200. https://doi.org/10.1038/emboj.2011.352

Salasova, A., Monti, G., Andersen, O. M. & Nykjaer, A. (2022). Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease. Molecular Neurodegeneration, 17(1), Article 74. https://doi.org/10.1186/s13024-022-00576-2

Salasova, A., Degn, N. S., Paveliev, M., Madsen, N. K., Ovesen, P. L., Vestergaard , B., Udrea, A.-C., Kisiswa, L., Woloszczuková, L., Faress, I. M. G., Nabavi, S., Holm, M. M., Kjolby, M., Bølcho, U. & Nykjær, A. (2021). SorCS2 dynamically interacts with TrkB and GluN2B to control neurotransmission and Huntington's disease progression. https://doi.org/10.1101/2021.11.03.466767

Salasova, A. & Nykjær, A. (2025). Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems. Neural Regeneration Research, 20(9), 2591-2593. https://doi.org/10.4103/NRR.NRR-D-24-00734

Rohde, P. D., Nyegaard, M., Kjolby, M. & Sørensen, P. (2021). Multi-Trait Genomic Risk Stratification for Type 2 Diabetes. Frontiers in Medicine, 8, Article 711208. https://doi.org/10.3389/fmed.2021.711208

Richner, M., Bjerrum, O. J., Nykjær, A. & Vægter, C. B. (2011). The Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice. Journal of Visualized Experiments, 54. http://www.jove.com/details.php?id=3092

Richner, M., Bjerrum, O. J., Koninck, Y. D., Nykjaer, A. & Vaegter, C. B. (2012). Sortilins in neuropathic pain. Scandinavian Journal of Pain, 3(3), 183-183. https://doi.org/10.1016/j.sjpain.2012.05.028

Richner, M., Pallesen, L. T., Ulrichsen, M., Poulsen, E. T., Holm, T. H., Login, H., Castonguay, A., Lorenzo, L.-E., Gonçalves, N. P., Andersen, O. M., Lykke-Hartmann, K., Enghild, J. J., Rønn, L. C. B., Malik, I. J., De Koninck, Y., Bjerrum, O. J., Vægter, C. B. & Nykjær, A. (2019). Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain. Science Advances, 5(6), Article eaav9946. https://doi.org/10.1126/sciadv.aav9946

Rhein, P., Desjardins, E. M., Rong, P., Ahwazi, D., Bonhoure, N., Stolte, J., Santos, M. D., Ovens, A. J., Ehrlich, A. M., Sanchez Garcia, J. L., Ouyang, Q., Yabut, J. M., Kjolby, M. F., Membrez, M., Jessen, N., Oakhill, J. S., Treebak, J. T., Maire, P., Scott, J. W. ... Sakamoto, K. (2021). Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle. Molecular Metabolism, 51, Article 101228. https://doi.org/10.1016/j.molmet.2021.101228

Reiche, J., Theilig, F., Rafiqi, F. H., Militz, D., Mutig, K., Todiras, M., Christensen, E. I., Ellison, D. H., Bader, M., Nykjaer, A., Bachmann, S., Alessi, D. & Willnow, T. E. (2010). SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na+-K+-Cl- cotransporter 2. Molecular and Cellular Biology, 30, 3027-3037. https://doi.org/10.1128/MCB.01560-09

Pottier, C., Zhou, X., Perkerson, R. B., Baker, M., Jenkins, G. D., Serie, D. J., Ghidoni, R., Benussi, L., Binetti, G., López de Munain, A., Zulaica, M., Moreno, F., Le Ber, I., Pasquier, F., Hannequin, D., Sánchez-Valle, R., Antonell, A., Lladó, A., Parsons, T. M. ... Rademakers, R. (2018). Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. The Lancet Neurology, 17(6), 548-558. https://doi.org/10.1016/S1474-4422(18)30126-1

Petersen, C. M., Ellgaard, L., Nykjær, A., Vilhardt, F., Vorum, H., Thøgersen, H. C., Nielsen, M. S., Jacobsen, C., Moestrup, S. K. & Gliemann, J. (1996). The receptor-associated protein (RAP) binds calmodulin and is phosphorylated by calmodulin-dependent kinase II. E M B O Journal, 15(16), 4165-4173.

Petersen, C. M., Nielsen, M. S., Nykjær, A., Jacobsen, L., Tommerup, N., Rasmussen, H., Røigaard, H., Gliemann, J., Madsen, P. S. & Moestrup, S. K. (1997). Molecular identification of anovel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography. Journal of Biological Chemistry, 272, 3599-3605.

Pedersen, I. B., Kjolby, M., Hjelholt, A. J., Madsen, M., Christensen, A. M. R., Adolfsen, D., Hjelle, J. S., Kremke, B., Støvring, H., Jessen, N., Vestergaard, E. T., Kristensen, K. & Frobert, O. (2024). INfluenza VaccInation to mitigate typE 1 Diabetes (INVITED): A study protocol for a randomised, double-blind, placebo-controlled clinical trial in children and adolescents with recent-onset type 1 diabetes. BMJ Open, 14(6), Article e084808. https://doi.org/10.1136/bmjopen-2024-084808

Parrish, D. C., Francis Stuart, S. D., Olivas, A., Wang, L., Nykjaer, A., Ripplinger, C. M. & Habecker, B. A. (2018). Transient denervation of viable myocardium after myocardial infarction does not alter arrhythmia susceptibility. A J P: Heart and Circulatory Physiology (Online), 314(3), H415-H423. https://doi.org/10.1152/ajpheart.00300.2017

Olsen, D., Kaas, M., Schwartz, O., Nykjaer, A. & Glerup, S. (2013). Loss of BDNF or its receptors in three mouse models has unpredictable consequences for anxiety and fear acquisition. Learning & Memory (Online), 20(9), 499-504. https://doi.org/10.1101/lm.032045.113

Olsen, D., Kaas, M., Lundhede, J., Molgaard, S., Nykjær, A., Kjolby, M., Østergaard, S. D. & Glerup, S. (2019). Reduced Alcohol Seeking and Withdrawal Symptoms in Mice Lacking the BDNF Receptor SorCS2. Frontiers in Pharmacology, 10(MAY), Article 499. https://doi.org/10.3389/fphar.2019.00499

Olsen, D., Wellner, N., Ollendorff, M. K., de Jong, I. E. M., Sotty, F., Didriksen, M., Glerup, S. & Nykjær, A. (2021). Altered dopaminergic firing pattern and novelty response underlie ADHD-like behavior of SorCS2-deficient mice. Translational Psychiatry, 11(1), Article 74. https://doi.org/10.1038/s41398-021-01199-9

Nykjær, A., Fyfe, J. C., Kozyraki, R., Leheste, J. R., Jacobsen, C., Nielsen, M. S., Verroust, P. J., Aminoff, M., de la Chapelle, A., Moestrup, S. K., Ray, R., Gliemann, J., Willnow, T. E. & Christensen, E. I. (2001). Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3). Proceedings of the National Academy of Sciences (PNAS), 98, 13895-13900.

Nykjær, A. & Willnow, T. E. (2002). The low-density lipoprotein receptor gene family: a cellular Swiss army knife? Trends Cell Biol., 12(6), 273-280.

Displaying results 1 to 50 out of 167

Revised 15.03.2021

Susanne Schousboe Sjøgaard