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Gholipourshahraki, T., Bai, Z., Shrestha, M., Hjelholt, A., Hu, S., Kjolby, M., Rohde, P. D. & Sørensen, P. (2024). Evaluation of Bayesian Linear Regression models for gene set prioritization in complex diseases. PLOS Genetics, 20(11 November), Article e1011463. https://doi.org/10.1371/journal.pgen.1011463

Indira Chandran, V., Gopala, S., Venkat, E. H., Kjolby, M. & Nejsum, P. (2024). Extracellular vesicles in glioblastoma: a challenge and an opportunity. npj Precision Oncology, 8(1), Article 103. https://doi.org/10.1038/s41698-024-00600-2

Pedersen, I. B., Kjolby, M., Hjelholt, A. J., Madsen, M., Christensen, A. M. R., Adolfsen, D., Hjelle, J. S., Kremke, B., Støvring, H., Jessen, N., Vestergaard, E. T., Kristensen, K. & Frobert, O. (2024). INfluenza VaccInation to mitigate typE 1 Diabetes (INVITED): A study protocol for a randomised, double-blind, placebo-controlled clinical trial in children and adolescents with recent-onset type 1 diabetes. BMJ Open, 14(6), Article e084808. https://doi.org/10.1136/bmjopen-2024-084808

Hansen, J. S., Boix, F., Hasselstrøm, J. B., Sørensen, L. K., Kjolby, M., Gustavsen, S., Hansen, R. M., Petersen, T., Sellebjerg, F., Kasch, H., Rasmussen, P. V., Finnerup, N. B., Saedder, E. A. & Svendsen, K. B. (2024). Pharmacokinetics and pharmacodynamics of cannabis-based medicine in a patient population included in a randomized, placebo-controlled, clinical trial. Clinical and Translational Science, 17(1), Article e13685. https://doi.org/10.1111/cts.13685

Skeldal, S., Voss, L. F., Lende, J., Pedersen, S. B., Mølgaard, S., Kaas, M., Demange, P., Bentsen, A. H., Fuglsang, M., Sander, M. R., Buttenschøn, H., Gustafsen, C., Madsen, P. & Glerup, S. (2023). Alternative splicing regulates adaptor protein binding, trafficking, and activity of the Vps10p domain receptor SorCS2 in neuronal development. Journal of Biological Chemistry, 299(9), Article 105102. https://doi.org/10.1016/j.jbc.2023.105102

Lopes-Rodrigues, V., Boxy, P., Sim, E., Park, D. I., Habeck, M., Carbonell, J., Andersson, A., Fernández-Suárez, D., Nissen, P., Nykjær, A. & Kisiswa, L. (2023). AraC interacts with p75^NTR transmembrane domain to induce cell death of mature neurons. Cell Death and Disease, 14(7), Article 440. https://doi.org/10.1038/s41419-023-05979-7

Boxy, P., Nykjær, A. & Kisiswa, L. (2023). Building better brains: the pleiotropic function of neurotrophic factors in postnatal cerebellar development. Frontiers in Molecular Neuroscience, 16, Article 1181397. https://doi.org/10.3389/fnmol.2023.1181397

Maimaitili, M., Chen, M., Febbraro, F., Ucuncu, E., Kelly, R., Niclis, J. C., Christiansen, J. R., Mermet-Joret, N., Niculescu, D., Lauritsen, J., Iannielli, A., Klæstrup, I. H., Jensen, U. B., Qvist, P., Nabavi, S., Broccoli, V., Nykjær, A., Romero-Ramos, M. & Denham, M. (2023). Enhanced production of mesencephalic dopaminergic neurons from lineage-restricted human undifferentiated stem cells. Nature Communications, 14(1), Article 7871. https://doi.org/10.1038/s41467-023-43471-0

Monti, G., Vincke, C., Lunding, M., Jensen, A. M. G., Madsen, P., Muyldermans, S., Kjolby, M. & Andersen, O. M. (2023). Epitope mapping of nanobodies binding the Alzheimer's disease receptor SORLA. Journal of Biotechnology, 375, 17-27. https://doi.org/10.1016/j.jbiotec.2023.08.005

Hjelholt, A. J., Bergh, C., Bhatt, D. L., Fröbert, O. & Kjolby, M. F. (2023). Pleiotropic Effects of Influenza Vaccination. Vaccines, 11(9), Article 1419. https://doi.org/10.3390/vaccines11091419

Thomasen, P. B., Salasova, A., Kjaer-Sorensen, K., Woloszczuková, L., Lavický, J., Login, H., Tranberg-Jensen, J., Almeida, S., Beel, S., Kavková, M., Qvist, P., Kjolby, M., Ovesen, P. L., Nolte, S., Vestergaard, B., Udrea, A.-C., Nejsum, L. N., Chao, M. V., Van Damme, P. ... Nykjaer, A. (2023). SorCS2 binds progranulin to regulate motor neuron development. Cell Reports, 42(11), Article 113333. https://doi.org/10.1016/j.celrep.2023.113333

Jakobsen, T. S., Østergaard, J. A., Kjolby, M., Birch, E. L., Bek, T., Nykjaer, A., Corydon, T. J. & Askou, A. L. (2023). Sortilin Inhibition Protects Neurons From Degeneration in the Diabetic Retina. Investigative Ophthalmology & Visual Science, 64(7), Article 8. https://doi.org/10.1167/iovs.64.7.8

Jankowski, V., Saritas, T., Kjolby, M., Hermann, J., Speer, T., Himmelsbach, A., Mahr, K., Heuschkel, M. A., Schunk, S. J., Thirup, S., Winther, S., Bottcher, M., Nyegard, M., Nykjaer, A., Kramann, R., Kaesler, N., Jankowski, J., Floege, J., Marx, N. & Goettsch, C. (2022). Carbamylated sortilin associates with cardiovascular calcification in patients with chronic kidney disease. Kidney International, 101(3), 574-584. https://doi.org/10.1016/j.kint.2021.10.018

Salasova, A., Monti, G., Andersen, O. M. & Nykjaer, A. (2022). Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease. Molecular Neurodegeneration, 17(1), Article 74. https://doi.org/10.1186/s13024-022-00576-2

Mikkelsen, R. R., Hundahl, M. P., Torp, C. K., Rodríguez-Carrio, J., Kjolby, M., Bruun, J. M. & Kragstrup, T. W. (2022). Immunomodulatory and immunosuppressive therapies in cardiovascular disease and type 2 diabetes mellitus: A bedside-to-bench approach. European Journal of Pharmacology, 925, Article 174998. https://doi.org/10.1016/j.ejphar.2022.174998

Ulrichsen, M., Gonçalves, N. P., Mohseni, S., Hjæresen, S., Lisle, T. L., Molgaard, S., Madsen, N. K., Andersen, O. M., Svenningsen, Å. F., Glerup, S., Nykjær, A. & Vægter, C. B. (2022). Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve Injury. Frontiers in Cellular Neuroscience, 16, Article 856734. https://doi.org/10.3389/fncel.2022.856734

Ahring, K. K., Dagnæs-Hansen, F., Brüel, A., Christensen, M., Jensen, E., Jensen, T. G., Johannsen, M., Johansen, K. S., Lund, A. M., Madsen, J. G., Brøndum-Nielsen, K., Pedersen, M., Sørensen, L. K., Kjolby, M. & Møller, L. B. (2022). The effect of casein glycomacropeptide versus free synthetic amino acids for early treatment of phenylketonuria in a mice model. PLOS ONE, 17(1), Article e0261150. https://doi.org/10.1371/journal.pone.0261150

van der Sluis, R. M., Cham, L. B., Gris-Oliver, A., Gammelgaard, K. R., Pedersen, J. G., Idorn, M., Ahmadov, U., Hernandez, S. S., Cémalovic, E., Godsk, S. H., Thyrsted, J., Gunst, J. D., Nielsen, S. D., Jørgensen, J. J., Bjerg, T. W., Laustsen, A., Reinert, L. S., Olagnier, D., Bak, R. O. ... Jakobsen, M. R. (2022). TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection. EMBO Journal, 41(10), Article e109622. https://doi.org/10.15252/embj.2021109622

Olsen, D., Wellner, N., Ollendorff, M. K., de Jong, I. E. M., Sotty, F., Didriksen, M., Glerup, S. & Nykjær, A. (2021). Altered dopaminergic firing pattern and novelty response underlie ADHD-like behavior of SorCS2-deficient mice. Translational Psychiatry, 11(1), Article 74. https://doi.org/10.1038/s41398-021-01199-9

Breining, P., Frølund, A. L., Højen, J. F., Gunst, J. D., Staerke, N. B., Sædder, E. A., Cases-Thomas, M., Little, P., Nielsen, L. P., Søgaard, O. S. & Kjolby, M. (2021). Camostat mesylate against SARS-CoV-2 and COVID-19-Rationale, dosing and safety. Basic & Clinical Pharmacology & Toxicology, 128(2), 204-212. https://doi.org/10.1111/bcpt.13533

Hoffmann, M., Hofmann-Winkler, H., Smith, J. C., Krüger, N., Arora, P., Sørensen, L. K., Søgaard, O. S., Hasselstrøm, J. B., Winkler, M., Hempel, T., Raich, L., Olsson, S., Danov, O., Jonigk, D., Yamazoe, T., Yamatsuta, K., Mizuno, H., Ludwig, S., Noé, F. ... Pöhlmann, S. (2021). Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity. EBioMedicine, 65, Article 103255. https://doi.org/10.1016/j.ebiom.2021.103255

Rhein, P., Desjardins, E. M., Rong, P., Ahwazi, D., Bonhoure, N., Stolte, J., Santos, M. D., Ovens, A. J., Ehrlich, A. M., Sanchez Garcia, J. L., Ouyang, Q., Yabut, J. M., Kjolby, M. F., Membrez, M., Jessen, N., Oakhill, J. S., Treebak, J. T., Maire, P., Scott, J. W. ... Sakamoto, K. (2021). Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle. Molecular Metabolism, 51, Article 101228. https://doi.org/10.1016/j.molmet.2021.101228

Sørensen, L. K., Hasselstrøm, J. B., Damsgaard Gunst, J., Søgaard, O. S. & Kjolby, M. (2021). Determination of camostat and its metabolites in human plasma – Preservation of samples and quantification by a validated UHPLC-MS/ MS method. Clinical Biochemistry, 96, 56-62. https://doi.org/10.1016/j.clinbiochem.2021.07.007

Cham, L. B., Pahus, M. H., Grønhøj, K., Olesen, R., Ngo, H., Monrad, I., Kjolby, M., Tolstrup, M., Gunst, J. D. & Søgaard, O. S. (2021). Effect of age on innate and adaptive immunity in hospitalized covid-19 patients. Journal of Clinical Medicine, 10(20), Article 4798. https://doi.org/10.3390/jcm10204798

Gunst, J. D., Staerke, N. B., Pahus, M. H., Kristensen, L. H., Bodilsen, J., Lohse, N., Dalgaard, L. S., Brønnum, D., Fröbert, O., Hønge, B., Johansen, I. S., Monrad, I., Erikstrup, C., Rosendal, R., Vilstrup, E., Mariager, T., Bove, D. G., Offersen, R., Shakar, S. ... Søgaard, O. S. (2021). Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial. EClinicalMedicine, 35, Article 100849. https://doi.org/10.1016/j.eclinm.2021.100849

Monti, G., Kjolby, M., Jensen, A. M. G., Allen, M., Reiche, J., Møller, P. L., Comaposada-Baró, R., Zolkowski, B. E., Vieira, C., Jørgensen, M. M., Holm, I. E., Valdmanis, P. N., Wellner, N., Vægter, C. B., Lincoln, S. J., Nykjær, A., Ertekin-Taner, N., Young, J. E., Nyegaard, M. & Andersen, O. M. (2021). Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer's disease. Acta Neuropathologica Communications, 9(1), Article 43. https://doi.org/10.1186/s40478-021-01140-7

Rohde, P. D., Nyegaard, M., Kjolby, M. & Sørensen, P. (2021). Multi-Trait Genomic Risk Stratification for Type 2 Diabetes. Frontiers in Medicine, 8, Article 711208. https://doi.org/10.3389/fmed.2021.711208

Breining, P., Pedersen, S. B., Kjolby, M., Hansen, J. B., Jessen, N. & Richelsen, B. (2021). Parathyroid hormone receptor stimulation induces human adipocyte lipolysis and browning. European Journal of Endocrinology, 184(5), 687-697. https://doi.org/10.1530/EJE-20-0713

Møller, P. L., Rohde, P. D., Winther, S., Breining, P., Nissen, L., Nykjær, A., Böttcher, M., Nyegaard, M. & Kjolby, M. (2021). Sortilin as a Biomarker for Cardiovascular Disease Revisited. Frontiers in Cardiovascular Medicine, 8, Article 652584. https://doi.org/10.3389/fcvm.2021.652584

Bernth Jensen, J. M., Skeldal, S., Petersen, M. S., Møller, B. K., Hoffmann, S., Jensenius, J. C., Sørensen, U. B. S. & Thiel, S. (2021). The human natural anti-αGal antibody targets common pathogens by broad-spectrum polyreactivity. Immunology, 162(4), 434-451. https://doi.org/10.1111/imm.13297

Møhlenberg, M., Monrad, I., Vibholm, L. K., Nielsen, S. S. F., Frattari, G. S., Schleimann, M. H., Olesen, R., Kjolby, M., Gunst, J. D., Søgaard, O. S., O'Brien, T. R., Tolstrup, M. & Hartmann, R. (2021). The Impact of IFNλ4 on the Adaptive Immune Response to SARS-CoV-2 Infection. Journal of Interferon and Cytokine Research, 41(11), 407-414. https://doi.org/10.1089/jir.2021.0106

Jensen, M. H., Kjolby, M., Hejlesen, O., Jakobsen, P. E. & Vestergaard, P. (2020). Risk of Major Adverse Cardiovascular Events, Severe Hypoglycemia, and All-Cause Mortality for Widely Used Antihyperglycemic Dual and Triple Therapies for Type 2 Diabetes Management: A Cohort Study of All Danish Users. Diabetes Care, 43(6), 1209-1218. https://doi.org/10.2337/dc19-2535

Graae, A.-S., Grarup, N., Ribel-Madsen, R., Lystbæk, S. H., Boesgaard, T., Staiger, H., Fritsche, A., Wellner, N., Sulek, K., Kjolby, M., Backe, M. B., Chubanava, S., Prats, C., Serup, A. K., Birk, J. B., Dubail, J., Gillberg, L., Vienberg, S. G., Nykjær, A. ... Holst, B. (2019). ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations. Diabetes, 68(3), 502-514. https://doi.org/10.2337/db18-0418

Hagensen, M. K., Mortensen, M. B., Kjolby, M., Palmfeldt, J., Bentzon, J. F. & Gregersen, S. (2019). Increased retention of LDL from type 1 diabetic patients in atherosclerosis-prone areas of the murine arterial wall. Atherosclerosis, 286, 156-162. https://doi.org/10.1016/j.atherosclerosis.2019.02.027

Olsen, D., Kaas, M., Lundhede, J., Molgaard, S., Nykjær, A., Kjolby, M., Østergaard, S. D. & Glerup, S. (2019). Reduced Alcohol Seeking and Withdrawal Symptoms in Mice Lacking the BDNF Receptor SorCS2. Frontiers in Pharmacology, 10(MAY), Article 499. https://doi.org/10.3389/fphar.2019.00499

Malik, A. R., Szydlowska, K., Nizinska, K., Asaro, A., van Vliet, E. A., Popp, O., Dittmar, G., Fritsche-Guenther, R., Kirwan, J. A., Nykjaer, A., Lukasiuk, K., Aronica, E. & Willnow, T. E. (2019). SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology. Cell Reports, 26(10), 2792-2804.e6. https://doi.org/10.1016/j.celrep.2019.02.027

Richner, M., Pallesen, L. T., Ulrichsen, M., Poulsen, E. T., Holm, T. H., Login, H., Castonguay, A., Lorenzo, L.-E., Gonçalves, N. P., Andersen, O. M., Lykke-Hartmann, K., Enghild, J. J., Rønn, L. C. B., Malik, I. J., De Koninck, Y., Bjerrum, O. J., Vægter, C. B. & Nykjær, A. (2019). Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain. Science Advances, 5(6), Article eaav9946. https://doi.org/10.1126/sciadv.aav9946

Blechingberg, J., Poulsen, A. S. A., Kjølby, M., Monti, G., Allen, M., Ivarsen, A. K., Lincoln, S. J., Thotakura, G., Vægter, C. B., Ertekin-Taner, N., Nykjær, A. & Andersen, O. M. (2018). An alternative transcript of the Alzheimer's disease risk gene SORL1 encodes a truncated receptor. Neurobiology of Aging, 71, 266.e11-266.e24. https://doi.org/10.1016/j.neurobiolaging.2018.06.021

Højland, A., Richner, M., Mølgaard, S., Dieu, R. S., Eskelund, A., Nykjær, A., Nyengaard, J. R., Lykkesfeldt, J., Glerup, S. & Nielsen, M. S. (2018). Biochemical and cognitive effects of docosahexaenoic acid differ in a developmental and SorLA dependent manner. Behavioural Brain Research, 348, 90-100. https://doi.org/10.1016/j.bbr.2018.04.017

Buttenschøn, H. N., Elfving, B., Nielsen, M., Skeldal, S., Kaas, M., Mors, O. & Glerup, S. (2018). Exploring the sortilin related receptor, SorLA, in depression. Journal of Affective Disorders, 232, 260-267. https://doi.org/10.1016/j.jad.2018.02.050

Pottier, C., Zhou, X., Perkerson, R. B., Baker, M., Jenkins, G. D., Serie, D. J., Ghidoni, R., Benussi, L., Binetti, G., López de Munain, A., Zulaica, M., Moreno, F., Le Ber, I., Pasquier, F., Hannequin, D., Sánchez-Valle, R., Antonell, A., Lladó, A., Parsons, T. M. ... Rademakers, R. (2018). Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. The Lancet Neurology, 17(6), 548-558. https://doi.org/10.1016/S1474-4422(18)30126-1

Smith, A. H., Ovesen, P. L., Skeldal, S., Yeo, S., Jensen, K. P., Olsen, D., Diazgranados, N., Zhao, H., Farrer, L. A., Goldman, D., Glerup, S., Kranzler, H. R., Nykjaer, A. & Gelernter, J. (2018). Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2. Alcoholism: Clinical and Experimental Research, 42(12), 2337-2348. https://doi.org/10.1111/acer.13890

Goettsch, C., Kjølby, M. F. & Aikawa, E. (2018). Sortilin and Its Multiple Roles in Cardiovascular and Metabolic Diseases. Arteriosclerosis, Thrombosis, and Vascular Biology, 38(1), 19-25. https://doi.org/10.1161/ATVBAHA.117.310292

Parrish, D. C., Francis Stuart, S. D., Olivas, A., Wang, L., Nykjaer, A., Ripplinger, C. M. & Habecker, B. A. (2018). Transient denervation of viable myocardium after myocardial infarction does not alter arrhythmia susceptibility. A J P: Heart and Circulatory Physiology (Online), 314(3), H415-H423. https://doi.org/10.1152/ajpheart.00300.2017

Dudele, A., Hougaard, K. S., Kjølby, M., Hokland, M., Winther, G., Elfving, B., Wegener, G., Nielsen, A. L., Larsen, A., Nøhr, M. K., Pedersen, S. B., Wang, T. & Lund, S. (2017). Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner. International Journal of Obesity, 41(9), 1420-1426. https://doi.org/10.1038/ijo.2017.136

Jacobsen, K., Lund, M. B., Shim, J., Gunnersen, S., Füchtbauer, E.-M., Kjolby, M., Carramolino, L. & Bentzon, J. F. (2017). Diverse cellular architecture of atherosclerotic plaque derives from clonal expansion of a few medial SMCs. JCI Insight, 2(19), Article e95890. https://doi.org/10.1172/jci.insight.95890

Januliene, D., Manavalan, A., Ovesen, P. L., Pedersen, K. M., Thirup, S., Nykjær, A. & Moeller, A. (2017). Hidden Twins: SorCS Neuroreceptors Form Stable Dimers. Journal of Molecular Biology, 429(19), 2907-2917. https://doi.org/10.1016/j.jmb.2017.08.006

Jønsson, K. L., Laustsen, A., Krapp, C., Skipper, K. A., Thavachelvam, K., Hotter, D., Egedal, J. H., Kjolby, M., Mohammadi, P., Prabakaran, T., Sørensen, L. K., Sun, C., Jensen, S. B., Holm, C. K., Lebbink, R. J., Johannsen, M., Nyegaard, M., Mikkelsen, J. G., Kirchhoff, F. ... Jakobsen, M. R. (2017). IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. Nature Communications, 8, Article 14391. https://doi.org/10.1038/ncomms14391