Publications

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Harvey, A. C., Bølcho, U., Main, B., Nykjær, A., Holm, M. M., Nissen, P., Kjærgaard, M. & Poulsen, H. (2026). Grin2b 3’UTR is necessary for synaptic plasticity and spatial learning. PNAS, 123(8), Article e2518282123. https://doi.org/10.1073/pnas.2518282123

Morsing, A. E., Green, K., Clausen, S., Benjaminsen, C. R., Blaavand, M. S., Demtröder, J. K., Skraep, J., Jensen, L., Breining, P., Kjolby, M., Vendelbo, M., Degn, S. E. & Thomsen, M. K. (2025). Age-associated B cells enhance tertiary lymphoid structures in the liver and promote HCC formation. Hepatology Communications, 9(10), Article e0816. https://doi.org/10.1097/HC9.0000000000000816

Salasova, A. & Nykjær, A. (2025). Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems. Neural Regeneration Research, 20(9), 2591-2593. https://doi.org/10.4103/NRR.NRR-D-24-00734

Shrestha, M., Bai, Z., Gholipourshahraki, T., Hjelholt, A. J., Hu, S., Kjolby, M., Rohde, P. D. & Sørensen, P. (2025). Enhanced genetic fine mapping accuracy with Bayesian Linear Regression models in diverse genetic architectures. PLoS Genetics, 21(7), 1-30. Article e1011783. https://doi.org/10.1371/journal.pgen.1011783

Hjelholt, A. J., Gholipourshahraki, T., Bai, Z., Shrestha, M., Kjolby, M., Sørensen, P. & Rohde, P. D. (2025). Leveraging genetic correlations to prioritize drug groups for repurposing in type 2 diabetes. The Pharmacogenomics Journal, 25(6), Article 33. https://doi.org/10.1038/s41397-025-00392-z

Gould, E., Fraser, H. S., Parker, T. H., Nakagawa, S., Griffith, S. C., Vesk, P. A., Fidler, F., Hamilton, D. G., Abbey-Lee, R. N., Abbott, J. K., Aguirre, L. A., Alcaraz, C., Aloni, I., Altschul, D., Arekar, K., Atkins, J. W., Atkinson, J., Baker, C. M., Barrett, M. ... Zitomer, R. A. (2025). Same data, different analysts: variation in effect sizes due to analytical decisions in ecology and evolutionary biology. BMC Biology, 23(1), Article 35. https://doi.org/10.1186/s12915-024-02101-x

Staehr, C., Login, H., Melnikova, E., Bakun, M., Ziemlinska, E., Kisiswa, L., Berenji Ardestani, S., Nolte, S. S., Beck, H. C., Hansen, L. M. B., Postnov, D., Verkhratsky, A., Malik, A. R., Nykjær, A. & Matchkov, V. (2025). SorCS2 Is Important for Astrocytic Function in Neurovascular Signaling. Acta Physiologica (Print), 241(6), Article e70052. https://doi.org/10.1111/apha.70052

Kjolby, M. (2025, Jun 23). Vaccinering mod herpes zoster nedsætter risiko for demens. (13 ed.) Ugeskrift for Læger

Gamaleldin, M., Yu, N. K., Diedrich, J. K., Ma, Y., Wienand, A., McClatchy, D. B., Nykjaer, A., Nabavi, S. & Yates, J. R. (2024). DiDBiT-TMT: A Novel Method to Quantify Changes in the Proteomic Landscape Induced by Neural Plasticity. Journal of Proteome Research, 23(11), 4878-4895. https://doi.org/10.1021/acs.jproteome.4c00180

Bai, Z., Gholipourshahraki, T., Shrestha, M., Hjelholt, A., Hu, S., Kjolby, M., Rohde, P. D. & Sørensen, P. (2024). Evaluation of Bayesian Linear Regression derived gene set test methods. BMC Genomics, 25(1), Article 1236. https://doi.org/10.1186/s12864-024-11026-2

Gholipourshahraki, T., Bai, Z., Shrestha, M., Hjelholt, A., Hu, S., Kjolby, M., Rohde, P. D. & Sørensen, P. (2024). Evaluation of Bayesian Linear Regression models for gene set prioritization in complex diseases. PLoS Genetics, 20(11), Article e1011463. https://doi.org/10.1371/journal.pgen.1011463

Indira Chandran, V., Gopala, S., Venkat, E. H., Kjolby, M. & Nejsum, P. (2024). Extracellular vesicles in glioblastoma: a challenge and an opportunity. npj Precision Oncology, 8(1), Article 103. https://doi.org/10.1038/s41698-024-00600-2

Pedersen, I. B., Kjolby, M., Hjelholt, A. J., Madsen, M., Christensen, A. M. R., Adolfsen, D., Hjelle, J. S., Kremke, B., Støvring, H., Jessen, N., Vestergaard, E. T., Kristensen, K. & Frobert, O. (2024). INfluenza VaccInation to mitigate typE 1 Diabetes (INVITED): A study protocol for a randomised, double-blind, placebo-controlled clinical trial in children and adolescents with recent-onset type 1 diabetes. BMJ Open, 14(6), Article e084808. https://doi.org/10.1136/bmjopen-2024-084808

Hansen, J. S., Boix, F., Hasselstrøm, J. B., Sørensen, L. K., Kjolby, M., Gustavsen, S., Hansen, R. M., Petersen, T., Sellebjerg, F., Kasch, H., Rasmussen, P. V., Finnerup, N. B., Saedder, E. A. & Svendsen, K. B. (2024). Pharmacokinetics and pharmacodynamics of cannabis-based medicine in a patient population included in a randomized, placebo-controlled, clinical trial. Clinical and Translational Science, 17(1), Article e13685. https://doi.org/10.1111/cts.13685

Kjolby, M. (2024). RNA-terapeutika. In U. Simonsen, K. P. Dalhoff, T. K. Bergmann & M. Rosenkilde (Eds.), Basal og klinisk farmakologi 7. udgave (7 ed., pp. 79-83). FADL's Forlag.

Lopes-Rodrigues, V., Boxy, P., Sim, E., Park, D. I., Habeck, M., Carbonell, J., Andersson, A., Fernández-Suárez, D., Nissen, P., Nykjær, A. & Kisiswa, L. (2023). AraC interacts with p75^NTR transmembrane domain to induce cell death of mature neurons. Cell Death and Disease, 14(7), Article 440. https://doi.org/10.1038/s41419-023-05979-7

Boxy, P., Nykjær, A. & Kisiswa, L. (2023). Building better brains: the pleiotropic function of neurotrophic factors in postnatal cerebellar development. Frontiers in Molecular Neuroscience, 16, Article 1181397. https://doi.org/10.3389/fnmol.2023.1181397

Maimaitili, M., Chen, M., Febbraro, F., Ucuncu, E., Kelly, R., Niclis, J. C., Christiansen, J. R., Mermet-Joret, N., Niculescu, D., Lauritsen, J., Iannielli, A., Klæstrup, I. H., Jensen, U. B., Qvist, P., Nabavi, S., Broccoli, V., Nykjær, A., Romero-Ramos, M. & Denham, M. (2023). Enhanced production of mesencephalic dopaminergic neurons from lineage-restricted human undifferentiated stem cells. Nature Communications, 14(1), Article 7871. https://doi.org/10.1038/s41467-023-43471-0

Monti, G., Vincke, C., Lunding, M., Jensen, A. M. G., Madsen, P., Muyldermans, S., Kjolby, M. & Andersen, O. M. (2023). Epitope mapping of nanobodies binding the Alzheimer's disease receptor SORLA. Journal of Biotechnology, 375, 17-27. https://doi.org/10.1016/j.jbiotec.2023.08.005

Hjelholt, A. J., Bergh, C., Bhatt, D. L., Fröbert, O. & Kjolby, M. F. (2023). Pleiotropic Effects of Influenza Vaccination. Vaccines, 11(9), Article 1419. https://doi.org/10.3390/vaccines11091419

Thomasen, P. B., Salasova, A., Kjaer-Sorensen, K., Woloszczuková, L., Lavický, J., Login, H., Tranberg-Jensen, J., Almeida, S., Beel, S., Kavková, M., Qvist, P., Kjolby, M., Ovesen, P. L., Nolte, S., Vestergaard, B., Udrea, A.-C., Nejsum, L. N., Chao, M. V., Van Damme, P. ... Nykjaer, A. (2023). SorCS2 binds progranulin to regulate motor neuron development. Cell Reports, 42(11), Article 113333. https://doi.org/10.1016/j.celrep.2023.113333

Staehr, C., Login, H., Postnov, D., Berenji Ardestani, S., Nolte, S. S., Beck, H. C., Nykjær, A. & Matchkov, V. (2023). SorCS2 modulates neurovascular coupling via glutamatergic and calcium signaling in astrocytes. bioRxiv. https://doi.org/10.1101/2023.02.16.528727

Jakobsen, T. S., Østergaard, J. A., Kjolby, M., Birch, E. L., Bek, T., Nykjaer, A., Corydon, T. J. & Askou, A. L. (2023). Sortilin Inhibition Protects Neurons From Degeneration in the Diabetic Retina. Investigative Ophthalmology & Visual Science, 64(7), Article 8. https://doi.org/10.1167/iovs.64.7.8

Jankowski, V., Saritas, T., Kjolby, M., Hermann, J., Speer, T., Himmelsbach, A., Mahr, K., Heuschkel, M. A., Schunk, S. J., Thirup, S., Winther, S., Bottcher, M., Nyegard, M., Nykjaer, A., Kramann, R., Kaesler, N., Jankowski, J., Floege, J., Marx, N. & Goettsch, C. (2022). Carbamylated sortilin associates with cardiovascular calcification in patients with chronic kidney disease. Kidney International, 101(3), 574-584. https://doi.org/10.1016/j.kint.2021.10.018

Salasova, A., Monti, G., Andersen, O. M. & Nykjaer, A. (2022). Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease. Molecular Neurodegeneration, 17(1), Article 74. https://doi.org/10.1186/s13024-022-00576-2

Mikkelsen, R. R., Hundahl, M. P., Torp, C. K., Rodríguez-Carrio, J., Kjolby, M., Bruun, J. M. & Kragstrup, T. W. (2022). Immunomodulatory and immunosuppressive therapies in cardiovascular disease and type 2 diabetes mellitus: A bedside-to-bench approach. European Journal of Pharmacology, 925, Article 174998. https://doi.org/10.1016/j.ejphar.2022.174998

Ulrichsen, M., Gonçalves, N. P., Mohseni, S., Hjæresen, S., Lisle, T. L., Molgaard, S., Madsen, N. K., Andersen, O. M., Svenningsen, Å. F., Glerup, S., Nykjær, A. & Vægter, C. B. (2022). Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve Injury. Frontiers in Cellular Neuroscience, 16, Article 856734. https://doi.org/10.3389/fncel.2022.856734

Ahring, K. K., Dagnæs-Hansen, F., Brüel, A., Christensen, M., Jensen, E., Jensen, T. G., Johannsen, M., Johansen, K. S., Lund, A. M., Madsen, J. G., Brøndum-Nielsen, K., Pedersen, M., Sørensen, L. K., Kjolby, M. & Møller, L. B. (2022). The effect of casein glycomacropeptide versus free synthetic amino acids for early treatment of phenylketonuria in a mice model. PLoS One, 17(1), Article e0261150. https://doi.org/10.1371/journal.pone.0261150

Olsen, D., Wellner, N., Ollendorff, M. K., de Jong, I. E. M., Sotty, F., Didriksen, M., Glerup, S. & Nykjær, A. (2021). Altered dopaminergic firing pattern and novelty response underlie ADHD-like behavior of SorCS2-deficient mice. Translational Psychiatry, 11(1), Article 74. https://doi.org/10.1038/s41398-021-01199-9

Breining, P., Frølund, A. L., Højen, J. F., Gunst, J. D., Staerke, N. B., Sædder, E. A., Cases-Thomas, M., Little, P., Nielsen, L. P., Søgaard, O. S. & Kjolby, M. (2021). Camostat mesylate against SARS-CoV-2 and COVID-19-Rationale, dosing and safety. Basic & Clinical Pharmacology & Toxicology, 128(2), 204-212. https://doi.org/10.1111/bcpt.13533

Hoffmann, M., Hofmann-Winkler, H., Smith, J. C., Krüger, N., Arora, P., Sørensen, L. K., Søgaard, O. S., Hasselstrøm, J. B., Winkler, M., Hempel, T., Raich, L., Olsson, S., Danov, O., Jonigk, D., Yamazoe, T., Yamatsuta, K., Mizuno, H., Ludwig, S., Noé, F. ... Pöhlmann, S. (2021). Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity. EBioMedicine, 65, Article 103255. https://doi.org/10.1016/j.ebiom.2021.103255

Rhein, P., Desjardins, E. M., Rong, P., Ahwazi, D., Bonhoure, N., Stolte, J., Santos, M. D., Ovens, A. J., Ehrlich, A. M., Sanchez Garcia, J. L., Ouyang, Q., Yabut, J. M., Kjolby, M. F., Membrez, M., Jessen, N., Oakhill, J. S., Treebak, J. T., Maire, P., Scott, J. W. ... Sakamoto, K. (2021). Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle. Molecular Metabolism, 51, Article 101228. https://doi.org/10.1016/j.molmet.2021.101228

Sørensen, L. K., Hasselstrøm, J. B., Damsgaard Gunst, J., Søgaard, O. S. & Kjolby, M. (2021). Determination of camostat and its metabolites in human plasma – Preservation of samples and quantification by a validated UHPLC-MS/ MS method. Clinical Biochemistry, 96, 56-62. https://doi.org/10.1016/j.clinbiochem.2021.07.007

Jacobsen, K., Lund, M. B., Shim, J., Gunnersen, S., Füchtbauer, E.-M., Kjolby, M., Carramolino, L. & Bentzon, J. F. (2021). Diverse cellular architecture of atherosclerotic plaque derives from clonal expansion of a few medial SMCs. JCI Insight, 2(19), Article e95890. https://doi.org/10.1172/jci.insight.95890

Cham, L. B., Pahus, M. H., Grønhøj, K., Olesen, R., Ngo, H., Monrad, I., Kjolby, M., Tolstrup, M., Gunst, J. D. & Søgaard, O. S. (2021). Effect of Age on Innate and Adaptive Immunity in Hospitalized COVID-19 Patients. Journal of Clinical Medicine, 10(20), Article 4798. https://doi.org/10.3390/jcm10204798, https://doi.org/10.3390/jcm10204798

Gunst, J. D., Staerke, N. B., Pahus, M. H., Kristensen, L. H., Bodilsen, J., Lohse, N., Dalgaard, L. S., Brønnum, D., Fröbert, O., Hønge, B., Johansen, I. S., Monrad, I., Erikstrup, C., Rosendal, R., Vilstrup, E., Mariager, T., Bove, D. G., Offersen, R., Shakar, S. ... Søgaard, O. S. (2021). Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial. EClinicalMedicine, 35, Article 100849. https://doi.org/10.1016/j.eclinm.2021.100849

Monti, G., Kjolby, M., Jensen, A. M. G., Allen, M., Reiche, J., Møller, P. L., Comaposada-Baró, R., Zolkowski, B. E., Vieira, C., Jørgensen, M. M., Holm, I. E., Valdmanis, P. N., Wellner, N., Vægter, C. B., Lincoln, S. J., Nykjær, A., Ertekin-Taner, N., Young, J. E., Nyegaard, M. & Andersen, O. M. (2021). Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer's disease. Acta Neuropathologica Communications, 9(1), Article 43. https://doi.org/10.1186/s40478-021-01140-7

Rohde, P. D., Nyegaard, M., Kjolby, M. & Sørensen, P. (2021). Multi-Trait Genomic Risk Stratification for Type 2 Diabetes. Frontiers in Medicine, 8, Article 711208. https://doi.org/10.3389/fmed.2021.711208

Breining, P., Pedersen, S. B., Kjolby, M., Hansen, J. B., Jessen, N. & Richelsen, B. (2021). Parathyroid hormone receptor stimulation induces human adipocyte lipolysis and browning. European Journal of Endocrinology, 184(5), 687-697. https://doi.org/10.1530/EJE-20-0713

Salasova, A., Degn, N. S., Paveliev, M., Madsen, N. K., Ovesen, P. L., Vestergaard , B., Udrea, A.-C., Kisiswa, L., Woloszczuková, L., Faress, I. M. G., Nabavi, S., Holm, M. M., Kjolby, M., Bølcho, U. & Nykjær, A. (2021). SorCS2 dynamically interacts with TrkB and GluN2B to control neurotransmission and Huntington's disease progression. https://doi.org/10.1101/2021.11.03.466767

Møller, P. L., Rohde, P. D., Winther, S., Breining, P., Nissen, L., Nykjær, A., Böttcher, M., Nyegaard, M. & Kjolby, M. (2021). Sortilin as a Biomarker for Cardiovascular Disease Revisited. Frontiers in Cardiovascular Medicine, 8, Article 652584. https://doi.org/10.3389/fcvm.2021.652584

Møhlenberg, M., Monrad, I., Vibholm, L. K., Nielsen, S. S. F., Frattari, G. S., Schleimann, M. H., Olesen, R., Kjolby, M., Gunst, J. D., Søgaard, O. S., O'Brien, T. R., Tolstrup, M. & Hartmann, R. (2021). The Impact of IFNλ4 on the Adaptive Immune Response to SARS-CoV-2 Infection. Journal of Interferon & Cytokine Research, 41(11), 407-414. https://doi.org/10.1089/jir.2021.0106

Jensen, M. H., Kjolby, M., Hejlesen, O., Jakobsen, P. E. & Vestergaard, P. (2020). Risk of Major Adverse Cardiovascular Events, Severe Hypoglycemia, and All-Cause Mortality for Widely Used Antihyperglycemic Dual and Triple Therapies for Type 2 Diabetes Management: A Cohort Study of All Danish Users. Diabetes Care, 43(6), 1209-1218. https://doi.org/10.2337/dc19-2535

Kjolby, M., Pedersen, K. M., Breining, P., Wellner, N., Sørensen, K. M. J., Vittrup, D. M., Gjesing, A. M. P., Januliene, D., Manavalan, A., Rotman, M., Thotakura, G., Skeldal, S., Madsen, P., Thirup, S., Hermey, G., Vaegter, C. B., Möller, A., Asplund, O., Prasad, R. B. ... Nykjaer, A. (2020). SorCS1 binds the insulin receptor to enhance insulin sensitivity. bioRxiv. https://doi.org/10.1101/2020.11.10.376178

Graae, A.-S., Grarup, N., Ribel-Madsen, R., Lystbæk, S. H., Boesgaard, T., Staiger, H., Fritsche, A., Wellner, N., Sulek, K., Kjolby, M., Backe, M. B., Chubanava, S., Prats, C., Serup, A. K., Birk, J. B., Dubail, J., Gillberg, L., Vienberg, S. G., Nykjær, A. ... Holst, B. (2019). ADAMTS9 regulates skeletal muscle insulin sensitivity through extracellular matrix alterations. Diabetes, 68(3), 502-514. https://doi.org/10.2337/db18-0418

Hagensen, M. K., Mortensen, M. B., Kjolby, M., Palmfeldt, J., Bentzon, J. F. & Gregersen, S. (2019). Increased retention of LDL from type 1 diabetic patients in atherosclerosis-prone areas of the murine arterial wall. Atherosclerosis, 286, 156-162. https://doi.org/10.1016/j.atherosclerosis.2019.02.027

Olsen, D., Kaas, M., Lundhede, J., Molgaard, S., Nykjær, A., Kjolby, M., Østergaard, S. D. & Glerup, S. (2019). Reduced Alcohol Seeking and Withdrawal Symptoms in Mice Lacking the BDNF Receptor SorCS2. Frontiers in Pharmacology, 10(MAY), Article 499. https://doi.org/10.3389/fphar.2019.00499

Malik, A. R., Szydlowska, K., Nizinska, K., Asaro, A., van Vliet, E. A., Popp, O., Dittmar, G., Fritsche-Guenther, R., Kirwan, J. A., Nykjaer, A., Lukasiuk, K., Aronica, E. & Willnow, T. E. (2019). SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology. Cell Reports, 26(10), 2792-2804.e6. https://doi.org/10.1016/j.celrep.2019.02.027

Richner, M., Pallesen, L. T., Ulrichsen, M., Poulsen, E. T., Holm, T. H., Login, H., Castonguay, A., Lorenzo, L.-E., Gonçalves, N. P., Andersen, O. M., Lykke-Hartmann, K., Enghild, J. J., Rønn, L. C. B., Malik, I. J., De Koninck, Y., Bjerrum, O. J., Vægter, C. B. & Nykjær, A. (2019). Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain. Science Advances, 5(6), Article eaav9946. https://doi.org/10.1126/sciadv.aav9946

Displaying results 1 to 50 out of 170

Revised 15.03.2021

Susanne Schousboe Sjøgaard