Publications

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Nykjær, A., Lee, R., Teng, K. K., Jansen, P., Madsen, P. S., Nielsen, M. S., Jacobsen, C., Kliemannel, M., Schwarz, E., Willnow, T. E., Hempstead, B. L. & Pedersen, J. C. M. (2004). Sortilin is essential for proNGF-induced neuronal cell death. Nature, 427, 843-848.

Nykjær, A., Willnow, T. E. & Pedersen, J. C. M. (2005). p75^NTR – To live or let die. Current Opinion in Neurobiology, 15, 49-57.

Nykjær, A., Petersen, C. M., Møller, B., Jensen, P. H., Moestrup, S. K., Holtet, T. L., Etzerodt, M., Thøgersen, H. C., Munch, M., Andreasen, P. & Gliemann, J. (1992). Purified alpha(2)-Macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha(2)-Macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes. Journal of Biological Chemistry, 267(21), 14543-14546.

Nykjær, A., Nielsen, M. S., Meyer, M., Røigaard, H., Etzerodt, M., Lookene, A., Beisiegel, U., Olivecrona, G. & Gliemann, J. (1994). A C-terminal fragment of lipoprotein lipase binds to LDL receptor-related protein and inhibits lipase-mediated uptake of β-VLDL lipoprotien particles. Journal of Biological Chemistry, 267, 31747-31755.

Nykjær, A. & Kjølby, M. F. (2009). (WO/2009/140972) MODULATION OF THE VPS10P-DOMAIN RECEPTORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE. (Patent No. PCT/DK2009/050115).

Nykjaer, A., Møller, B. K., Todd, R. F., Christensen, T., Andreasen, P., Gliemann, J. & Petersen, C. M. (1994). Urokinase receptor. An activation antigen in human T lymphocytes. Journal of Immunology, 152(2), 505-16.

Nykjaer, A., Schambye, H., Pedersen, A. H. & Nielsen, H. (2009). Assessing low-dose gentamicin-induced kidney injury in rats by analysis of urine. Journal of Pharmacological and Toxicological Methods, 60(3), 316-20. https://doi.org/10.1016/j.vascn.2009.07.006

Nykjaer, A. & Willnow, T. E. (2012). Sortilin: a receptor to regulate neuronal viability and function. Trends in Neurosciences, 35(4), 261-70. https://doi.org/10.1016/j.tins.2012.01.003

Nielsen, M. S., Madsen, P. S., Christensen, E. I., Nykjær, A., Gliemann, J., Kasper, D., Pohlmann, R. & Pedersen, J. C. M. (2001). The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein. EMBO Journal, 20, 2180-2190.

Nielsen, M. S., Nykjær, A., Warshawsky, I., Schwartz, A. L. & Gliemann, J. (1995). Analysis of ligand binding to the α2-macroglobulin receptor/low density lipoprotein receptor-related protein. Journal of Biological Chemistry, 270, 23713-23719.

Muller, D., Nykjær, A. & Willnow, T. E. (2003). From holoprosencephaly to osteopathology: role of multifunctional endocytic receptors in absorptive epithelia. Annals of Medicine, (35), 290-299.

Mufson, E. J., Wuu, J., Counts, S. E. & Nykjaer, A. (2010). Preservation of cortical sortilin protein levels in MCI and Alzheimer's disease. Neuroscience Letters, 471(3), 129-33. https://doi.org/10.1016/j.neulet.2010.01.023

Mortensen, M. B., Kjolby, M., Gunnersen, S., Larsen, J. V., Palmfeldt, J., Falk, E., Nykjaer, A. & Bentzon, J. F. (2014). Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis. Journal of Clinical Investigation, 124(12), 5317-5322. https://doi.org/10.1172/JCI76002

Mortensen, M. B., Kjolby, M. & Bentzon, J. F. (2015). Sortilin and atherosclerosis. OncoTarget, 6(23), 19352-3.

Morsing, A. E., Green, K., Clausen, S., Benjaminsen, C. R., Blaavand, M. S., Demtröder, J. K., Skraep, J., Jensen, L., Breining, P., Kjolby, M., Vendelbo, M., Degn, S. E. & Thomsen, M. K. (2025). Age-associated B cells enhance tertiary lymphoid structures in the liver and promote HCC formation. Hepatology Communications, 9(10), Article e0816. https://doi.org/10.1097/HC9.0000000000000816

Monti, G., Kjolby, M., Jensen, A. M. G., Allen, M., Reiche, J., Møller, P. L., Comaposada-Baró, R., Zolkowski, B. E., Vieira, C., Jørgensen, M. M., Holm, I. E., Valdmanis, P. N., Wellner, N., Vægter, C. B., Lincoln, S. J., Nykjær, A., Ertekin-Taner, N., Young, J. E., Nyegaard, M. & Andersen, O. M. (2021). Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer's disease. Acta Neuropathologica Communications, 9(1), Article 43. https://doi.org/10.1186/s40478-021-01140-7

Monti, G., Vincke, C., Lunding, M., Jensen, A. M. G., Madsen, P., Muyldermans, S., Kjolby, M. & Andersen, O. M. (2023). Epitope mapping of nanobodies binding the Alzheimer's disease receptor SORLA. Journal of Biotechnology, 375, 17-27. https://doi.org/10.1016/j.jbiotec.2023.08.005

Møller, P. L., Rohde, P. D., Winther, S., Breining, P., Nissen, L., Nykjær, A., Böttcher, M., Nyegaard, M. & Kjolby, M. (2021). Sortilin as a Biomarker for Cardiovascular Disease Revisited. Frontiers in Cardiovascular Medicine, 8, Article 652584. https://doi.org/10.3389/fcvm.2021.652584

Molgaard, S., Demontis, D., Nicholson, A. M., Finch, N. A., Petersen, R. C., Petersen, C. M., Rademakers, R., Nykjaer, A. & Glerup, S. (2016). Soluble sortilin is present in excess and positively correlates with progranulin in CSF of aging individuals. Experimental Gerontology, 84, 96-100. https://doi.org/10.1016/j.exger.2016.09.002

Møhlenberg, M., Monrad, I., Vibholm, L. K., Nielsen, S. S. F., Frattari, G. S., Schleimann, M. H., Olesen, R., Kjolby, M., Gunst, J. D., Søgaard, O. S., O'Brien, T. R., Tolstrup, M. & Hartmann, R. (2021). The Impact of IFNλ4 on the Adaptive Immune Response to SARS-CoV-2 Infection. Journal of Interferon & Cytokine Research, 41(11), 407-414. https://doi.org/10.1089/jir.2021.0106

Moestrup, S. K., Holtet, T. L., Etzerodt, M., Thøgersen, H. C., Nykjær, A., Andreasen, P., Rasmussen, H. H., Sottrup-Jensen, L. & Gliemann, J. (1993). Alpha 2-macroglobulin-proteinase complexes, plasminogen activator inhibitor type-1-plasminogen activator complexes, and receptor-associated protein bind to a region of the alpha(2)-Macroglobulin receptor containing a cluster of eight complement-type repeats. Journal of Biological Chemistry, 268(18), 13691-13696.

Moestrup, S. K., Nielsen, S., Andreasen, P., Jørgensen, K. E., Nykjaer, A., Røigaard, H., Gliemann, J. & Christensen, E. I. (1993). Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes. Journal of Biological Chemistry, 268(22), 16564-16570. http://www.jbc.org/content/268/22/16564.abstract?sid=6db3a4c4-d15a-479a-9233-8efe4a9667a9

Mikkelsen, R. R., Hundahl, M. P., Torp, C. K., Rodríguez-Carrio, J., Kjolby, M., Bruun, J. M. & Kragstrup, T. W. (2022). Immunomodulatory and immunosuppressive therapies in cardiovascular disease and type 2 diabetes mellitus: A bedside-to-bench approach. European Journal of Pharmacology, 925, Article 174998. https://doi.org/10.1016/j.ejphar.2022.174998

Malik, A. R., Szydlowska, K., Nizinska, K., Asaro, A., van Vliet, E. A., Popp, O., Dittmar, G., Fritsche-Guenther, R., Kirwan, J. A., Nykjaer, A., Lukasiuk, K., Aronica, E. & Willnow, T. E. (2019). SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology. Cell Reports, 26(10), 2792-2804.e6. https://doi.org/10.1016/j.celrep.2019.02.027

Maimaitili, M., Chen, M., Febbraro, F., Ucuncu, E., Kelly, R., Niclis, J. C., Christiansen, J. R., Mermet-Joret, N., Niculescu, D., Lauritsen, J., Iannielli, A., Klæstrup, I. H., Jensen, U. B., Qvist, P., Nabavi, S., Broccoli, V., Nykjær, A., Romero-Ramos, M. & Denham, M. (2023). Enhanced production of mesencephalic dopaminergic neurons from lineage-restricted human undifferentiated stem cells. Nature Communications, 14(1), Article 7871. https://doi.org/10.1038/s41467-023-43471-0

Lopes-Rodrigues, V., Boxy, P., Sim, E., Park, D. I., Habeck, M., Carbonell, J., Andersson, A., Fernández-Suárez, D., Nissen, P., Nykjær, A. & Kisiswa, L. (2023). AraC interacts with p75^NTR transmembrane domain to induce cell death of mature neurons. Cell Death and Disease, 14(7), Article 440. https://doi.org/10.1038/s41419-023-05979-7

Lisi, S., Madsen, P., Botta, R., Petersen, C. M., Nykjær, A., Latrofa, F., Vitti, P. & Marinò, M. (2015). ABSENCE OF A THYROID PHENOTYPE IN SORTILIN-DEFICIENT MICE. Endocrine Practice, 21(9), 981-985. https://doi.org/10.4158/EP15697.OR

Lewin, G. R. & Nykjaer, A. (2014). Pro-neurotrophins, sortilin, and nociception. The European journal of neuroscience, 39(3), 363-74. https://doi.org/10.1111/ejn.12466

Leheste, J. R., Melsen, F., Wellner, M., Jansen, P., Schlichting, U., Renner-Muller, I., Andreassen, T. T., Wolf, E., Bachmann, S., Nykjær, A. & Willnow, T. E. (2003). Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect. The FASEB Journal, (17), 247-249.

Klinger, S. C., Glerup, S., Raarup, M. K., Mari, M. C., Nyegaard, M., Koster, G., Prabakaran, T., Nilsson, B. S., Kjaergaard, M. M., Bakke, O., Nykjær, A., Olivecrona, G., Petersen, C. M. & Nielsen, M. S. (2011). SorLA regulates the activity of lipoprotein lipase by intracellular trafficking. Journal of Cell Science, 124(Pt 7), 1095-105. https://doi.org/10.1242/jcs.072538

Klinger, S. C., Glerup, S., Raarup, M. K., Mari, MC., Nyegaard, M., Koster, G., Prabakaran, T., Nilsson, SK., Kjærgaard, M. M., Bakke, O., Nykjær, A., Olivecrona, G., Petersen, C. M. & Nielsen, MS. (2011). SorLA regulates lipoprotein lipase activity by intracellular trafficking. Poster session presented at PhD Day 2011, Aarhus University, Faculty of Health Sciences, Aarhus, Denmark.

Klinger, S. C., Glerup, S., Raarup, M. K., Mari, MC., Nyegaard, M., Koster, G., Prabakaran, T., Nilsson, SK., Kjærgaard, M. M., Bakke, O., Nykjær, A., Olivecrona, G., Petersen, C. M. & Nielsen, MS. (2011). SorLA regulates lipoprotein lipase activity by intracellular trafficking. Abstract from PhD Day 2011, Aarhus University, Faculty of Health Sciences, Aarhus, Denmark.

Klinger, S. C., Højland, A., Gustafsen, C., Glerup, S., Kjølby, M. F., Helms, H. C., Raarup, M. K., Olivecrona, G., Brodin, B., Petersen, C. M., Nykjær, A. & Nielsen, M. S. (2012). SorLA regulates trafficking of Lipoprotein Lipase in polarized cells and astrocytes. Poster session presented at Barriers of the CNS, New London NH, United States.

Klinger, S. C., Højland, A., Jain, S., Kjolby, M., Madsen, P., Svendsen, A. D., Olivecrona, G., Bonifacino, J. S. & Nielsen, M. S. (2016). Polarized Trafficking of the Sorting Receptor SorLA in Neurons and MDCK Cells. FEBS journal, 283(13), 2476–2493. https://doi.org/10.1111/febs.13758

Kjølby, M. F. & Bie, P. (2008). Chronic activation of plasma renin is log-linearly related to dietary sodium and eliminates natriuresis in response to a pulse change in total body sodium. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 294(1), r17-25.

Kjølby, M. F., Kompanowska-Jezierska, E., Wamberg, S. & Bie, P. (2005). Effects of sodium intake on plasma potassium and renin angiotensin aldosterone system in conscious dogs. Acta Physiologica (Print), 184(3), 225-234.

Kjølby, M. F., Müller, K. & Schumacher, M. (2006). Cerebellopontine angle primary diffuse large B cell (non-Hodgkins) lymphoma mimicking an acoustic schwannoma. European Journal of Radiology Extra, 60(3), 93-96.

Kjølby, M. F., Andersen, O. M., Breiderhoff, T., Fjorback, A. N., Pedersen, K.-M., Madsen, P. S., Jansen, P., Heeren, J., Willnow, T. & Nykjær, A. (2010). Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export. Cell Metabolism, 12(3), 213-223.

Kjølby, M. F. (2010). Det store lotteri. Weekendavisen.

Kjølby, M. F. (2011). Sortilins in cardiovascular disease and diabetes. Aarhus Universitet.

Kjolby, M., Nielsen, M. S. & Petersen, C. M. (2015). Sortilin, encoded by the cardiovascular risk gene SORT1, and its suggested functions in cardiovascular disease. Current Atherosclerosis Reports, 17(4), 496. https://doi.org/10.1007/s11883-015-0496-7

Kjolby, M., Pedersen, K. M., Breining, P., Wellner, N., Sørensen, K. M. J., Vittrup, D. M., Gjesing, A. M. P., Januliene, D., Manavalan, A., Rotman, M., Thotakura, G., Skeldal, S., Madsen, P., Thirup, S., Hermey, G., Vaegter, C. B., Möller, A., Asplund, O., Prasad, R. B. ... Nykjaer, A. (2020). SorCS1 binds the insulin receptor to enhance insulin sensitivity. bioRxiv. https://doi.org/10.1101/2020.11.10.376178

Kjolby, M. (2024). RNA-terapeutika. In U. Simonsen, K. P. Dalhoff, T. K. Bergmann & M. Rosenkilde (Eds.), Basal og klinisk farmakologi 7. udgave (7 ed., pp. 79-83). FADL's Forlag.

Kjolby, M. (2025, Jun 23). Vaccinering mod herpes zoster nedsætter risiko for demens. (13 ed.) Ugeskrift for Læger

Kjærgaard, M., Skeldal, S., Raarup, M. K., Nykjær, A., Nyengaard, J. R. & Nielsen, M. S. (2008). Using FRET in the study of the Vps10pD receptors: Annual Meeting of the Nordic Microscopy Society (Scandem).

Jønsson, K. L., Laustsen, A., Krapp, C., Skipper, K. A., Thavachelvam, K., Hotter, D., Egedal, J. H., Kjolby, M., Mohammadi, P., Prabakaran, T., Sørensen, L. K., Sun, C., Jensen, S. B., Holm, C. K., Lebbink, R. J., Johannsen, M., Nyegaard, M., Mikkelsen, J. G., Kirchhoff, F. ... Jakobsen, M. R. (2017). IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP. Nature Communications, 8, Article 14391. https://doi.org/10.1038/ncomms14391

Jensen, M. H., Kjolby, M., Hejlesen, O., Jakobsen, P. E. & Vestergaard, P. (2020). Risk of Major Adverse Cardiovascular Events, Severe Hypoglycemia, and All-Cause Mortality for Widely Used Antihyperglycemic Dual and Triple Therapies for Type 2 Diabetes Management: A Cohort Study of All Danish Users. Diabetes Care, 43(6), 1209-1218. https://doi.org/10.2337/dc19-2535

Januliene, D., Manavalan, A., Ovesen, P. L., Pedersen, K. M., Thirup, S., Nykjær, A. & Moeller, A. (2017). Hidden Twins: SorCS Neuroreceptors Form Stable Dimers. Journal of Molecular Biology, 429(19), 2907-2917. https://doi.org/10.1016/j.jmb.2017.08.006

Jansen, P., Giehl, K., Nyengaard, J. R., Teng, K., Lioubinski, O., Sjoegaard, S. S., Breiderhoff, T., Gotthardt, M., Lin, F., Eilers, A., Petersen, C. M., Lewin, G. R., Hempstead, B. L., Willnow, T. E. & Nykjaer, A. (2007). Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nature Neuroscience, 10(11), 1449-57. https://doi.org/10.1038/nn2000

Jankowski, V., Saritas, T., Kjolby, M., Hermann, J., Speer, T., Himmelsbach, A., Mahr, K., Heuschkel, M. A., Schunk, S. J., Thirup, S., Winther, S., Bottcher, M., Nyegard, M., Nykjaer, A., Kramann, R., Kaesler, N., Jankowski, J., Floege, J., Marx, N. & Goettsch, C. (2022). Carbamylated sortilin associates with cardiovascular calcification in patients with chronic kidney disease. Kidney International, 101(3), 574-584. https://doi.org/10.1016/j.kint.2021.10.018

Displaying results 51 to 100 out of 170

Revised 15.03.2021

Susanne Schousboe Sjøgaard