De Chiara, I., Feola, A., Della Gala, M., Marasco, R.
, Nielsen, M. S., Porcellini, A., Grieco, M., Gentile, M. T. & Muscariello, L. (2026).
In vitro antitumor activity of Lactococcus lactis cell-free supernatant on human glioblastoma cell lines.
Food Research International,
223(Part 1), Article 117840.
https://doi.org/10.1016/j.foodres.2025.117840Bällgren, F., Svane, N., Ginosyan, A., Pedersen, A. B. V., Li, S., Mahajan, J.
, Nielsen, M. S., Brodin, B. & Loryan, I. (2025).
Comparative analysis of the uptake of the H+/OC antiporter substrate oxycodone across and into brain endothelial and parenchymal cells with in vitro–in vivo extrapolation.
Fluids and Barriers of the CNS,
22(1), Article 109.
https://doi.org/10.1186/s12987-025-00726-wEinarsson, H. B., Mortensen, A. F., Nielsen, M. S., Chen, M., Nielsen, S. R., Kraft, D. C. E., Jensen, J.
, Bjerre, M., Nygaard, J. V., Bünger, C. E. & Vorup-Jensen, T. (2025).
Osteoclast-like multinucleated giant cells reinforce polycaprolactone grafts.
Frontiers in Immunology,
16, Article 1572238.
https://doi.org/10.3389/fimmu.2025.1572238
Holst, M. R., Richner, M., Arenshøj, P. O., Alam, P., Hyldig, K. & Nielsen, M. S. (2024).
Ex vivo nanoscale abluminal mapping of putative cargo receptors at the blood-brain barrier of expanded brain capillaries.
Fluids and Barriers of the CNS,
21(1), Article 80.
https://doi.org/10.1186/s12987-024-00585-x
Kurtyka, M., Wessely, F., Bau, S., Ifie, E., He, L., de Wit, N. M., Pedersen, A. B. V., Keller, M., Webber, C., de Vries, H. E., Ansorge, O., Betsholtz, C., De Bock, M., Chaves, C., Brodin, B.
, Nielsen, M. S., Neuhaus, W., Bell, R. D., Letoha, T. ... Pietrzik, C. U. (2024).
The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier.
European Journal of Cell Biology,
103(2), Article 151406.
https://doi.org/10.1016/j.ejcb.2024.151406Nielsen, S. S. E., Holst, M. R., Langthaler, K., Christensen, S. C.
, Bruun, E. H., Brodin, B.
& Nielsen, M. S. (2023).
Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells.
Fluids and Barriers of the CNS,
20(1), Article 2.
https://doi.org/10.1186/s12987-022-00404-1
Ozgür, B., Puris, E., Brachner, A., Appelt-Menzel, A., Oerter, S., Balzer, V.
, Holst, M. R., Christiansen, R. F., Hyldig, K., Buckley, S. T., Kristensen, M., Auriola, S., Jensen, A., Fricker, G.
, Nielsen, M. S., Neuhaus, W. & Brodin, B. (2023).
Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line.
Fluids and Barriers of the CNS,
20(1), Article 96.
https://doi.org/10.1186/s12987-023-00501-9Hudecz, D., McCloskey, M. C., Vergo, S., Christensen, S., McGrath, J. L.
& Nielsen, M. S. (2023).
Modelling a Human Blood-Brain Barrier Co-Culture Using an Ultrathin Silicon Nitride Membrane-Based Microfluidic Device.
International Journal of Molecular Sciences ,
24(6), Article 5624.
https://doi.org/10.3390/ijms24065624
Holst, M. R., de Wit, N. M., Ozgür, B., Brachner, A., Hyldig, K., Appelt-Menzel, A., Sleven, H., Cader, Z., de Vries, H. E., Neuhaus, W., Jensen, A., Brodin, B.
& Nielsen, M. S. (2023).
Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier.
Fluids and Barriers of the CNS,
20(1), Article 82.
https://doi.org/10.1186/s12987-023-00480-x
Alam, P., Holst, M. R., Lauritsen, L.
, Nielsen, J., Nielsen, S. S. E., Jensen, P. H., Brewer, J. R.
, Otzen, D. E. & Nielsen, M. S. (2022).
Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers.
Fluids and Barriers of the CNS,
19(1), Article 37.
https://doi.org/10.1186/s12987-022-00334-y
Toth, A. E., Klepe, A., Lipka, D. V., Goldeman, C., Brodin, B.
& Nielsen, M. S. (2022).
SorLA in astrocytes regulates blood-brain barrier integrity.
Frontiers in Drug Delivery,
2, Article 1082689.
https://doi.org/10.3389/fddev.2022.1082689
Toth, A. E., Helms, H. C.
, Harazin, A., Johnsen, K. B., Goldeman, C., Burkhart, A., Thomsen, M. S., Kempen, P. J.
, Klepe, A., Lipka, D. V., Møller, P. L., Andresen, T. L.
, Nyegaard, M., Moos, T., Brodin, B.
& Nielsen, M. S. (2022).
Sortilin regulates blood-brain barrier integrity.
FEBS journal,
289(4), 1062-1079.
https://doi.org/10.1111/febs.16225
Christensen, S. C., Hudecz, D., Jensen, A., Christensen, S.
& Nielsen, M. S. (2021).
Basigin Antibodies with Capacity for Drug Delivery Across Brain Endothelial Cells.
Molecular Neurobiology,
58(9), 4392-4403.
https://doi.org/10.1007/s12035-021-02421-x
Yan, Y., Gu, T., Christensen, S. D. K., Su, J., Lassen, T. R., Hjortbak, M. V., Lo, I., Venø, S. T., Tóth, A. E., Song, P., Nielsen, M. S., Bøtker, H. E., Blagoev, B.
, Drasbek, K. R. & Kjems, J. (2021).
Cyclic hypoxia conditioning alters the content of myoblast-derived extracellular vesicles and enhances their cell-protective functions.
Biomedicines,
9(9), Article 1211.
https://doi.org/10.3390/biomedicines9091211
Hudecz, D., Sigurdardóttir, S. B.
, Christensen, S. C., Hempel, C., Urquhart, A. J., Andresen, T. L.
& Nielsen, M. S. (2021).
Two peptides targeting endothelial receptors are internalized into murine brain endothelial cells.
PLoS One,
16(4 ), Article e0249686.
https://doi.org/10.1371/journal.pone.0249686
Christensen, S. C., Krogh, B. O., Jensen, A.
, Andersen, C. B. F., Christensen, S.
& Nielsen, M. S. (2020).
Characterization of basigin monoclonal antibodies for receptor-mediated drug delivery to the brain.
Scientific Reports,
10(1), Article 14582.
https://doi.org/10.1038/s41598-020-71286-2
Kristensen, M., Kucharz, K., Felipe Alves Fernandes, E., Strømgaard, K.
, Schallburg Nielsen, M., Cederberg Helms, H. C., Bach, A., Ulrikkaholm Tofte-Hansen, M., Irene Aldana Garcia, B., Lauritzen, M. & Brodin, B. (2020).
Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation.
Pharmaceutics,
12(7), 1-24. Article 661.
https://doi.org/10.3390/pharmaceutics12070661Amoushahi, M., Steffensen, L. L., Galieva, A., Agger, J., Heuck, A., Siupka, P., Ernst, E., Nielsen, M. S., Sunde, L. & Lykke-Hartmann, K. (2020).
Maternally contributed Nlrp9b expressed in human and mouse ovarian follicles contributes to early murine preimplantation development.
Journal of Assisted Reproduction and Genetics,
37(6), 1355-1365.
https://doi.org/10.1007/s10815-020-01767-w
Christensen, B., Toth, A. E., Nielsen, S. S. E., Scavenius, C., Petersen, S. V., Enghild, J. J., Rasmussen, J. T., Nielsen, M. S. & Sørensen, E. S. (2020).
Transport of a peptide from bovine αs1-casein across models of the intestinal and blood–brain barriers.
Nutrients,
12(10), Article 3157.
https://doi.org/10.3390/nu12103157
Hudecz, D., Khire, T., Chung, H. L., Adumeau, L., Glavin, D., Luke, E.
, Nielsen, M. S., Dawson, K. A., McGrath, J. L. & Yan, Y. (2020).
Ultrathin Silicon Membranes for in Situ Optical Analysis of Nanoparticle Translocation across a Human Blood-Brain Barrier Model.
ACS Nano,
14(1), 1111-1122.
https://doi.org/10.1021/acsnano.9b08870
Madsen, P., Isaksen, T. J., Siupka, P., Tóth, A. E., Nyegaard, M., Gustafsen, C. & Nielsen, M. S. (2019).
HSPA12A targets the cytoplasmic domain and affects the trafficking of the Amyloid Precursor Protein receptor SorLA.
Scientific Reports,
9, Article 611.
https://doi.org/10.1038/s41598-018-37336-6
Leduc-Galindo, D., Qvist, P., Tóth, A. E., Fryland, T., Nielsen, M. S., Børglum, A. D. & Christensen, J. H. (2019).
The effect of hypoxia on ZEB1 expression in a mimetic system of the blood-brain barrier.
Microvascular Research,
122, 131-135.
https://doi.org/10.1016/j.mvr.2018.08.004
Toth, A. E., Nielsen, S. S. E., Tomaka, W., Abbott, N. J.
& Nielsen, M. S. (2019).
The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells.
Fluids and Barriers of the CNS,
16(1), Article 14.
https://doi.org/10.1186/s12987-019-0134-9
Johnsen, K. B., Bak, M., Kempen, P. J., Melander, F., Burkhart, A., Thomsen, M. S.
, Nielsen, M. S., Moos, T. & Andresen, T. L. (2018).
Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles.
Theranostics,
8(12), 3416-3436.
https://doi.org/10.7150/thno.25228Højland, A., Richner, M., Mølgaard, S., Dieu, R. S., Eskelund, A., Nykjær, A., Nyengaard, J. R., Lykkesfeldt, J.
, Glerup, S. & Nielsen, M. S. (2018).
Biochemical and cognitive effects of docosahexaenoic acid differ in a developmental and SorLA dependent manner.
Behavioural Brain Research,
348, 90-100.
https://doi.org/10.1016/j.bbr.2018.04.017
Toth, A. E., Siupka, P., P Augustine, T. J.
, Venø, S. T., Thomsen, L. B., Moos, T., Lohi, H. T.
, Madsen, P., Lykke-Hartmann, K. & Nielsen, M. S. (2018).
The Endo-Lysosomal System of Brain Endothelial Cells Is Influenced by Astrocytes In Vitro.
Molecular Neurobiology,
55(11), 8522-8537.
https://doi.org/10.1007/s12035-018-0988-x
Siupka, P., Hersom, M. N.
, Lykke-Hartmann, K., Johnsen, K. B., Thomsen, L. B., Andresen, T. L., Moos, T., Abbott, N. J., Brodin, B.
& Nielsen, M. S. (2017).
Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells.
Journal of Cerebral Blood Flow and Metabolism,
37(7), 2598-2613. Article 271678X17700665.
https://doi.org/10.1177/0271678X17700665
Nielsen, S. S. E., Siupka, P., Georgian, A., Preston, J. E.
, Tóth, A. E., Yusof, S. R., Abbott, N. J.
& Nielsen, M. S. (2017).
Improved Method for the Establishment of an In Vitro Blood-Brain Barrier Model Based on Porcine Brain Endothelial Cells.
Journal of Visualized Experiments,
2017(127), Article e56277.
https://doi.org/10.3791/56277
Strandgaard, T., Foder, S., Heuck, A., Ernst, E., Nielsen, M. S. & Lykke-Hartmann, K. (2017).
Maternally Contributed Folate Receptor 1 Is Expressed in Ovarian Follicles and Contributes to Preimplantation Development.
Frontiers in Cell and Developmental Biology,
5(SEP), Article 89.
https://doi.org/10.3389/fcell.2017.00089
Johnsen, K. B., Burkhart, A., Melander, F., Kempen, P. J., Vejlebo, J. B.
, Siupka, P., Nielsen, M. S., Andresen, T. L. & Moos, T. (2017).
Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma.
Scientific Reports,
7(1), 10396. Article 10396.
https://doi.org/10.1038/s41598-017-11220-1Larsen, J. V., Kristensen, A. M., Pallesen, L. T., Bauer, J., Vægter, C. B., Nielsen, M. S., Madsen, P. & Petersen, C. M. (2016).
Cytokine-like factor-1 (CLF-1): An essential facilitator of cardiotrophin-like cytokine: CNTFRα (CLC:CNTFRα) signalling and sorLA mediated turnover.
Molecular and Cellular Biology,
36(8), 1272-1286.
https://doi.org/10.1128/mcb.00917-15
Matrone, C., Dzamko, N.
, Madsen, P., Nyegaard, M., Pohlmann, R., Søndergaard, R. V.
, Lassen, L. B., Andresen, T. L., Halliday, G. M.
, Jensen, P. H. & Nielsen, M. S. (2016).
Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease.
PLoS One,
11(8), e0160501. Article e0160501.
https://doi.org/10.1371/journal.pone.0160501
