Publications

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Fazeli, E., Child, D. D., Bucks, S. A., Stovarsky, M., Edwards, G., Rose, S. E., Yu, C. E., Latimer, C., Kitago, Y., Bird, T., Jayadev, S., Andersen, O. M. & Young, J. E. (2024). A familial missense variant in the Alzheimer’s disease gene SORL1 impairs its maturation and endosomal sorting. Acta Neuropathologica, 147(1), Article 20. https://doi.org/10.1007/s00401-023-02670-1

Fazeli, E., Fazeli, E., Fojtík, P., Holstege, H. & Andersen, O. M. (2024). Functional characterization of SORL1 variants in cell-based assays to investigate variant pathogenicity. Philosophical Transactions of the Royal Society B: Biological Sciences, 379(1899), Article 20220377. https://doi.org/10.1098/rstb.2022.0377

Bøgh, N., Sørensen, C. B., Alstrup, A. K. O., Søvsø Szocska Hansen, E., Andersen, O. M. & Laustsen, C. (2024). Mice and minipigs with compromised expression of the Alzheimer's disease gene SORL1 show cerebral metabolic disturbances on hyperpolarized [1-¹³C]pyruvate and sodium MRI. Brain Communications, 6(2), Article fcae114. https://doi.org/10.1093/braincomms/fcae114

Kaminska, P., Ovesen, P. L., Jakiel, M., Obrebski, T., Schmidt, V., Draminski, M., Bilska, A. G., Bieniek, M., Anink, J., Paterczyk, B., Jensen, A. M. G., Piatek, S., Andersen, O. M., Aronica, E., Willnow, T. E., Kaminska, B., Dabrowski, M. J. & Malik, A. R. (2024). SorLA restricts TNFα release from microglia to shape a glioma-supportive brain microenvironment. EMBO Reports, 25(5), 2278-2305. https://doi.org/10.1038/s44319-024-00117-6

Jensen, A. M. G., Raska, J., Fojtik, P., Monti, G., Lunding, M., Bartova, S., Pospisilova, V., van der Lee, S. J., Van Dongen, J., Bossaerts, L., Van Broeckhoven, C., Dols-Icardo, O., Lléo, A., Bellini, S., Ghidoni, R., Hulsman, M., Petsko, G. A., Sleegers, K., Bohaciakova, D. ... Andersen, O. M. (2024). The SORL1 p.Y1816C variant causes impaired endosomal dimerization and autosomal dominant Alzheimer’s disease. Proceedings of the National Academy of Sciences of the United States of America, 121(37), Article e2408262121. https://doi.org/10.1073/pnas.2408262121

Jensen, A. M. G., Kitago, Y., Fazeli, E., Vægter, C. B., Small, S. A., Petsko, G. A. & Andersen, O. M. (2023). Dimerization of the Alzheimer's disease pathogenic receptor SORLA regulates its association with retromer. Proceedings of the National Academy of Sciences (PNAS), 120(4), Article e2212180120. https://doi.org/10.1073/pnas.2212180120

Monti, G., Vincke, C., Lunding, M., Jensen, A. M. G., Madsen, P., Muyldermans, S., Kjolby, M. & Andersen, O. M. (2023). Epitope mapping of nanobodies binding the Alzheimer's disease receptor SORLA. Journal of Biotechnology, 375, 17-27. https://doi.org/10.1016/j.jbiotec.2023.08.005

Young, J. E., Holstege, H., Andersen, O. M., Petsko, G. A. & Small, S. A. (2023). On the causal role of retromer-dependent endosomal recycling in Alzheimer’s disease. Nature Cell Biology, 25(10), 1394-1397. https://doi.org/10.1038/s41556-023-01245-2

Andersen, O. M., Bøgh, N., Landau, A. M., Pløen, G. G., Jensen, A. M. G., Monti, G., Ulhøi, B. P., Nyengaard, J. R., Jacobsen, K. R., Jørgensen, M. M., Holm, I. E., Kristensen, M. L., Alstrup, A. K. O., Hansen, E. S. S., Teunissen, C. E., Breidenbach, L., Droescher, M., Liu, Y., Pedersen, H. S. ... Sørensen, C. B. (2022). A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency. Cell Reports Medicine, 3(9), Article 100740. https://doi.org/10.1016/j.xcrm.2022.100740

Salasova, A., Monti, G., Andersen, O. M. & Nykjaer, A. (2022). Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease. Molecular Neurodegeneration, 17(1), Article 74. https://doi.org/10.1186/s13024-022-00576-2

Ulrichsen, M., Gonçalves, N. P., Mohseni, S., Hjæresen, S., Lisle, T. L., Molgaard, S., Madsen, N. K., Andersen, O. M., Svenningsen, Å. F., Glerup, S., Nykjær, A. & Vægter, C. B. (2022). Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve Injury. Frontiers in Cellular Neuroscience, 16, Article 856734. https://doi.org/10.3389/fncel.2022.856734

Mishra, S., Knupp, A., Szabo, M. P., Williams, C. A., Kinoshita, C., Hailey, D. W., Wang, Y., Andersen, O. M. & Young, J. E. (2022). The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons. Cellular and Molecular Life Sciences, 79(3), Article 162. https://doi.org/10.1007/s00018-022-04182-9

Al-Akhrass, H., Conway, J. R. W., Poulsen, A. S. A., Paatero, I., Kaivola, J., Padzik, A., Andersen, O. M. & Ivaska, J. (2021). A feed-forward loop between SorLA and HER3 determines heregulin response and neratinib resistance. Oncogene, 40(7), 1300-1317. https://doi.org/10.1038/s41388-020-01604-5

Simoes, S., Guo, J., Buitrago, L., Qureshi, Y. H., Feng, X., Kothiya, M., Cortes, E., Patel, V., Kannan, S., Kim, Y. H., Chang, K. T., Alzheimer's Disease Neuroimaging Initiative, Hussaini, S. A., Moreno, H., Di Paolo, G., Andersen, O. M. & Small, S. A. (2021). Alzheimer's vulnerable brain region relies on a distinct retromer core dedicated to endosomal recycling. Cell Reports, 37(13), Article 110182. https://doi.org/10.1016/j.celrep.2021.110182

Monti, G., Kjolby, M., Jensen, A. M. G., Allen, M., Reiche, J., Møller, P. L., Comaposada-Baró, R., Zolkowski, B. E., Vieira, C., Jørgensen, M. M., Holm, I. E., Valdmanis, P. N., Wellner, N., Vægter, C. B., Lincoln, S. J., Nykjær, A., Ertekin-Taner, N., Young, J. E., Nyegaard, M. & Andersen, O. M. (2021). Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer's disease. Acta Neuropathologica Communications, 9(1), Article 43. https://doi.org/10.1186/s40478-021-01140-7

Kjolby, M., Pedersen, K. M., Breining, P., Wellner, N., Sørensen, K. M. J., Vittrup, D. M., Gjesing, A. M. P., Januliene, D., Manavalan, A., Rotman, M., Thotakura, G., Skeldal, S., Madsen, P., Thirup, S., Hermey, G., Vaegter, C. B., Möller, A., Asplund, O., Prasad, R. B. ... Nykjaer, A. (2020). SorCS1 binds the insulin receptor to enhance insulin sensitivity. bioRxiv. https://doi.org/10.1101/2020.11.10.376178

Monti, G., Jensen, M. L., Mehmedbasic, A., Jørgensen, M. M., Holm, I. E., Barkholt, P., Zole, E., Vægter, C. B., Vorum, H., Nyengaard, J. R. & Andersen, O. M. (2020). SORLA Expression in Synaptic Plexiform Layers of Mouse Retina. Molecular Neurobiology, 57(7), 3106-3117. https://doi.org/10.1007/s12035-020-01946-x

Gonçalves, N. P., Mohseni, S., El Soury, M., Ulrichsen, M., Richner, M., Xiao, J., Wood, R. J., Andersen, O. M., Coulson, E. J., Raimondo, S., Murray, S. S. & Vægter, C. B. (2019). Peripheral Nerve Regeneration Is Independent From Schwann Cell p75NTR Expression. Frontiers in Cellular Neuroscience, 13, Article 235. https://doi.org/10.3389/fncel.2019.00235

Pietilä, M., Sahgal, P., Peuhu, E., Jäntti, N. Z., Paatero, I., Närvä, E., Al-Akhrass, H., Lilja, J., Georgiadou, M., Andersen, O. M., Padzik, A., Sihto, H., Joensuu, H., Blomqvist, M., Saarinen, I., Boström, P. J., Taimen, P. & Ivaska, J. (2019). SORLA regulates endosomal trafficking and oncogenic fitness of HER2. Nature Communications, 10(1), 1-16. Article 2340. https://doi.org/10.1038/s41467-019-10275-0

Richner, M., Pallesen, L. T., Ulrichsen, M., Poulsen, E. T., Holm, T. H., Login, H., Castonguay, A., Lorenzo, L.-E., Gonçalves, N. P., Andersen, O. M., Lykke-Hartmann, K., Enghild, J. J., Rønn, L. C. B., Malik, I. J., De Koninck, Y., Bjerrum, O. J., Vægter, C. B. & Nykjær, A. (2019). Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain. Science Advances, 5(6), Article eaav9946. https://doi.org/10.1126/sciadv.aav9946

Blechingberg, J., Poulsen, A. S. A., Kjølby, M., Monti, G., Allen, M., Ivarsen, A. K., Lincoln, S. J., Thotakura, G., Vægter, C. B., Ertekin-Taner, N., Nykjær, A. & Andersen, O. M. (2018). An alternative transcript of the Alzheimer's disease risk gene SORL1 encodes a truncated receptor. Neurobiology of Aging, 71, 266.e11-266.e24. https://doi.org/10.1016/j.neurobiolaging.2018.06.021

Mygind, K. J., Störiko, T., Freiberg, M. L., Samsøe-Petersen, J., Schwarz, J., Andersen, O. M. & Kveiborg, M. (2018). Sorting nexin 9 (SNX9) regulates levels of the transmembrane ADAM9 at the cell surface. Journal of Biological Chemistry, 293(21), 8077-8088. https://doi.org/10.1074/jbc.RA117.001077

Monti, G. & Andersen, O. M. (2017). 20 Years Anniversary for SORLA/SORL1 (1996-2016). Receptors and Clinical Investigation, 4(4), 2-10. Article e1611. https://doi.org/10.14800/rci.1611

Andersen, O. M., Nielsen, M. S. & Vægter, C. B. (2016). Aldehyder og ketoner. In Medicinsk kemi Systime. http://mk.systime.dk

Andersen, O. M., Nielsen, M. S. & Vægter, C. B. (2016). Alkener, alkyner og isomeri. In Medicinsk kemi Systime. http://mk.systime.dk

Andersen, O. M., Nielsen, M. S. & Vægter, C. B. (2016). Alkoholer, phenoler, ethere og thioler. In Medicinsk Kemi Systime. http://mk.systime.dk

Andersen, O. M., Nielsen, M. S. & Vægter, C. B. (2016). Aminer og amider. In Medicinsk kemi Systime. http://mk.systime.dk

Andersen, O. M., Nielsen, M. S. & Vægter, C. B. (2016). Bindinger og molekylestruktur. In Medicinsk kemi Systime.

Andersen, O. M., Nielsen, M. S. & Vægter, C. B. (2016). Carboxylsyrer og carboxylsyrederivater. In Medicinsk kemi Systime. http://mk.systime.dk

Andersen, O. M., Nielsen, M. S. & Vægter, C. B. (2016). Energetik. In Medicinsk Kemi Systime. http://mk.systime.dk

Andersen, O. M., Nielsen, M. S. & Vægter, C. B. (2016). Intermolekylære bindinger og tilstandsformer. In Medicinsk kemi Systime.

Andersen, O. M., Nielsen, M. S. & Vægter, C. B. (2016). Kemisk Ligevægt. In Medicinsk Kemi Systime. http://mk.systime.dk

Andersen, O. M., Nielsen, M. S. & Vægter, C. B. (2016). Kulhydrater. In Medicinsk Kemi Systime. http://mk.systime.dk

Andersen, O. M., Nielsen, M. S. & Vægter, C. B. (2016). Lipider. In Medicinsk Kemi Systime. http://mk.systime.dk

Andersen, O. M., Nielsen, M. S. & Vægter, C. B. (2016). Molekylestruktur og fysisk-kemiske egenskaber. In Medicinsk Kemi Systime.

Andersen, O. M., Nielsen, M. S. & Vægter, C. B. (2016). Nukleotider og nukleoinsyrer. In Medicinsk kemi Systime. http://mk.systime.dk

Andersen, O. M., Nielsen, M. S. & Vægter, C. B. (2016). Periodesystem og støkiometri. In Medicinsk kemi Systime.

Andersen, O. M., Nielsen, M. S. & Vægter, C. B. (2016). Reaktionskinitik og katalyse. In Medicinsk kemi Systime. http://mk.systime.dk

Andersen, O. M., Nielsen, M. S. & Vægter, C. B. (2016). Reduktorer og oxidatorer. In Medicinsk Kemi Systime.

Andersen, O. M., Rudolph, I.-M. & Willnow, T. E. (2016). Risk factor SORL1: from genetic association to functional validation in Alzheimer's disease. Acta Neuropathologica, 132(5), 653–665. https://doi.org/10.1007/s00401-016-1615-4

Glerup, S., Bolcho, U., Bøggild, S., Vaegter, C. B., Smith, A. H., Nieto-Gonzalez, J. L., Ovesen, P. L., Pedersen, L. F., Fjorback, A. N., Kjolby, M., Login, H., Holm, M. M., Andersen, O. M., Nyengaard, J. R., Willnow, T. E., Jensen, K., Nykjaer, A. & Jensen, S. M. (2016). SorCS2 is required for BDNF-dependent plasticity in the hippocampus. Molecular Psychiatry, 21(12), 1740-1751. https://doi.org/10.1038/mp.2016.108

Andersen, O. M., Nielsen, M. S. & Vægter, C. B. (2016). Syrer og baser. In Medicinsk Kemi Systime.

Andersen, O. M. & Thakurta, I. G. (2015). Assosiations of sorLA/SORL 1 With Alzheimer`s disease. https://doi.org/10.14800/rci.700

Dienemann, C., Coburger, I., Mehmedbasic, A., Andersen, O. M. & Than, M. E. (2015). Mutants of Metal Binding Site M1 in APP E2 Show Metal Specific Differences in Binding of Heparin but Not of sorLA. Biochemistry. https://doi.org/10.1021/acs.biochem.5b00111

Coulson, E. J. & Andersen, O. M. (2015). The A-B-C for SORting APP. Journal of Neurochemistry, 135(1), 1-3. https://doi.org/10.1111/jnc.13231

Andersen, O. M., Thakurta, I. G. & West, M. J. (2014). Development of an improved immunoassay for detection of sorLA in cells and biological samples.. Poster session presented at Alzheimer`s Association International Conference, Copenhagen, Denmark.

Andersen, O. M., Poulsen, A. S. A., Zole, E., Ivarsen, A. K., Blechingberg, J. & Vorum, H. (2014). Regulation of sorLA in general and in Alzheimer's disease. Poster session presented at Alzheimer`s Association International Conference, Copenhagen, Denmark.

Mehmedbasic, A., Christensen, S. K., Nilsson, J., Rüetschi, U., Gustafsen, C., Poulsen, A. S. A., Rasmussen, R. W., Fjorback, A. N., Larson, G. & Andersen, O. M. (2014). SorLA CR-Domains Protect the Amyloid Precursor Protein against Processing. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M114.619940

Andersen, O. M., Dagil, R. & Kragelund, B. B. (2013). New Horizons for Lipoprotein ReceptorsCommunication by β-propellers. Journal of Lipid Research, 54(10), 2763- 2774. https://doi.org/10.1194/jlr.M039545

Gustafsen, C., Glerup, S., Pallesen, L. T., Olsen, D., Andersen, O. M., Nykjær, A., Madsen, P. & Petersen, C. M. (2013). Sortilin and SorLA Display Distinct Roles in Processing and Trafficking of Amyloid Precursor Protein. Journal of Neuroscience, 33(1), 64-71. https://doi.org/10.1523/JNEUROSCI.2371-12.2013

Displaying results 1 to 50 out of 78

Revised 15.03.2021

Susanne Schousboe Sjøgaard