Skeldal, S., Voss, L. F., Lende, J., Pedersen, S. B., Mølgaard, S., Kaas, M.
, Demange, P., Bentsen, A. H.
, Fuglsang, M., Sander, M. R., Buttenschøn, H., Gustafsen, C., Madsen, P. & Glerup, S. (2023).
Alternative splicing regulates adaptor protein binding, trafficking, and activity of the Vps10p domain receptor SorCS2 in neuronal development.
Journal of Biological Chemistry,
299(9), Article 105102.
https://doi.org/10.1016/j.jbc.2023.105102
Pärn, A., Olsen, D., Tuvikene, J., Kaas, M., Borisova, E., Bilgin, M., Elhauge, M.
, Vilstrup, J., Madsen, P., Ambrozkiewicz, M. C., Goz, R. U., Timmusk, T., Tarabykin, V.
, Gustafsen, C. & Glerup, S. (2023).
PCSK9 deficiency alters brain lipid composition without affecting brain development and function.
Frontiers in Molecular Neuroscience,
15, Article 1084633.
https://doi.org/10.3389/fnmol.2022.1084633
Skeby, C. K., Hummelgaard, S., Gustafsen, C., Petrillo, F., Frederiksen, K. P., Olsen, D., Kristensen, T., Ivarsen, P., Madsen, P., Christensen, E. I., Nielsen, R., Birn, H., Glerup, S. & Weyer, K. (2023).
Proprotein convertase subtilisin/kexin type 9 targets megalin in the kidney proximal tubule and aggravates proteinuria in nephrotic syndrome.
Kidney International,
104(4), 754-768.
https://doi.org/10.1016/j.kint.2023.06.024
Hummelgaard, S., Vilstrup, J. P.
, Gustafsen, C., Glerup, S. & Weyer, K. (2023).
Targeting PCSK9 to tackle cardiovascular disease.
Pharmacology & Therapeutics,
249, Article 108480.
https://doi.org/10.1016/j.pharmthera.2023.108480
Al-Absi, A.-R., Thambiappa, S. K., Khan, A. R.
, Glerup, S., Sanchez, C., Landau, A. M. & Nyengaard, J. R. (2022).
Df(h22q11)/+ mouse model exhibits reduced binding levels of GABAA receptors and structural and functional dysregulation in the inhibitory and excitatory networks of hippocampus.
Molecular and Cellular Neuroscience,
122, Article 103769.
https://doi.org/10.1016/j.mcn.2022.103769
Ulrichsen, M., Gonçalves, N. P., Mohseni, S., Hjæresen, S., Lisle, T. L.
, Molgaard, S., Madsen, N. K., Andersen, O. M., Svenningsen, Å. F.
, Glerup, S., Nykjær, A. & Vægter, C. B. (2022).
Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve Injury.
Frontiers in Cellular Neuroscience,
16, Article 856734.
https://doi.org/10.3389/fncel.2022.856734
Olsen, D., Wellner, N., Ollendorff, M. K., de Jong, I. E. M., Sotty, F., Didriksen, M.
, Glerup, S. & Nykjær, A. (2021).
Altered dopaminergic firing pattern and novelty response underlie ADHD-like behavior of SorCS2-deficient mice.
Translational Psychiatry,
11(1), Article 74.
https://doi.org/10.1038/s41398-021-01199-9
Al-Absi, A.-R., Qvist, P., Glerup, S., Sanchez, C. & Nyengaard, J. R. (2021).
Df(h15q13)/+ Mouse Model Reveals Loss of Astrocytes and Synaptic-Related Changes of the Excitatory and Inhibitory Circuits in the Medial Prefrontal Cortex.
Cerebral Cortex,
31(3), 1609-1621.
https://doi.org/10.1093/cercor/bhaa313
Rasmussen, L. D., Bøttcher, M., Ivarsen, P., Jørgensen, H. S., Nyegaard, M., Buttenschøn, H., Gustafsen, C., Glerup, S., Bøtker, H. E., Svensson, M.
& Winther, S. (2020).
Association between circulating proprotein convertase subtilisin/kexin type 9 levels and prognosis in patients with severe chronic kidney disease.
Nephrology Dialysis Transplantation,
35(4), 632-639. Article gfy257.
https://doi.org/10.1093/ndt/gfy257
Al-Absi, A.-R., Qvist, P., Okujeni, S.
, Khan, A. R., Glerup, S., Sanchez, C. & Nyengaard, J. R. (2020).
Layers II/III of Prefrontal Cortex in Df(h22q11)/+ Mouse Model of the 22q11.2 Deletion Display Loss of Parvalbumin Interneurons and Modulation of Neuronal Morphology and Excitability.
Molecular Neurobiology,
57(12), 4978–4988 .
https://doi.org/10.1007/s12035-020-02067-1
Tachibana, M.
, Holm, M.-L., Liu, C.-C., Shinohara, M., Aikawa, T., Oue, H., Yamazaki, Y., Martens, Y. A., Murray, M. E., Sullivan, P. M.
, Weyer, K., Glerup, S., Dickson, D. W., Bu, G. & Kanekiyo, T. (2019).
APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1.
Journal of Clinical Investigation,
129(3), 1272-1277.
https://doi.org/10.1172/JCI124853Olsen, D., Kaas, M., Lundhede, J., Molgaard, S., Nykjær, A., Kjolby, M., Østergaard, S. D. & Glerup, S. (2019).
Reduced Alcohol Seeking and Withdrawal Symptoms in Mice Lacking the BDNF Receptor SorCS2.
Frontiers in Pharmacology,
10(MAY), Article 499.
https://doi.org/10.3389/fphar.2019.00499
Højland, A., Richner, M., Mølgaard, S., Dieu, R. S., Eskelund, A., Nykjær, A., Nyengaard, J. R., Lykkesfeldt, J.
, Glerup, S. & Nielsen, M. S. (2018).
Biochemical and cognitive effects of docosahexaenoic acid differ in a developmental and SorLA dependent manner.
Behavioural Brain Research,
348, 90-100.
https://doi.org/10.1016/j.bbr.2018.04.017
Qvist, P., Eskildsen, S. F., Hansen, B., Baragji, M., Ringgaard, S., Roovers, J.
, Paternoster, V., Molgaard, S., Corydon, T. J., Stødkilde-Jørgensen, H., Glerup, S., Mors, O., Wegener, G., Nyengaard, J. R., Børglum, A. D. & Christensen, J. H. (2018).
Brain volumetric alterations accompanied with loss of striatal medium-sized spiny neurons and cortical parvalbumin expressing interneurons in Brd1+/- mice.
Scientific Reports,
8(1), 16486. Article 16486.
https://doi.org/10.1038/s41598-018-34729-5
Buttenschøn, H. N., Elfving, B., Nielsen, M., Skeldal, S., Kaas, M., Mors, O. & Glerup, S. (2018).
Exploring the sortilin related receptor, SorLA, in depression.
Journal of Affective Disorders,
232, 260-267.
https://doi.org/10.1016/j.jad.2018.02.050
Smith, A. H.
, Ovesen, P. L., Skeldal, S., Yeo, S., Jensen, K. P.
, Olsen, D., Diazgranados, N., Zhao, H., Farrer, L. A., Goldman, D.
, Glerup, S., Kranzler, H. R.
, Nykjaer, A. & Gelernter, J. (2018).
Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2.
Alcoholism: Clinical and Experimental Research,
42(12), 2337-2348.
https://doi.org/10.1111/acer.13890Gustafsen, C., Olsen, D., Vilstrup, J., Lund, S., Reinhardt, A.
, Wellner, N., Larsen, T., Andersen, C. B. F., Weyer, K., Li, J.-P., Seeberger, P. H.
, Thirup, S., Madsen, P. & Glerup, S. (2017).
Heparan sulfate proteoglycans present PCSK9 to the LDL receptor.
Nature Communications,
8(1), 503. Article 503.
https://doi.org/10.1038/s41467-017-00568-7
Buttenschøn, H. N., Nielsen, M. N., Thotakura, G., Lee, C. W.
, Nykjær, A., Mors, O. & Glerup, S. (2017).
Progranulin gene variation affects serum progranulin levels differently in Danish bipolar individuals compared with healthy controls.
Psychiatric Genetics,
27(3), 89-95.
https://doi.org/10.1097/YPG.0000000000000168
Holm, T. H., Isaksen, T. J., Pedersen, S. G., Heuck, A., Bøttger, P., Füchtbauer, E.-M., Nedergaard, S. T., Nyengaard, J. R., Andreasen, M., Nissen, P. & Lykke-Hartmann, K. (2016).
Cognitive deficits caused by a disease-mutation in the α3 Na(+)/K(+)-ATPase isoform. Scientific Reports,
6(31972), Article 31972.
https://doi.org/10.1038/srep31972
Bøttger, P., Pedersen, S. G., Gesslein, B., Illarionova, N.
, Isaksen, T. J., Heuck, A., Clausen, B. H.
, Füchtbauer, E.-M., Gramsbergen, J. B., Gunnarson, E., Aperia, A., Lauritzen, M., Lambertsen, K. L.
, Nissen, P. & Lykke-Hartmann, K. (2016).
Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model.
Scientific Reports,
6(22047), Article 22047.
https://doi.org/10.1038/srep22047
Molgaard, S., Demontis, D., Nicholson, A. M., Finch, N. A., Petersen, R. C.
, Petersen, C. M., Rademakers, R.
, Nykjaer, A. & Glerup, S. (2016).
Soluble sortilin is present in excess and positively correlates with progranulin in CSF of aging individuals.
Experimental Gerontology,
84, 96-100.
https://doi.org/10.1016/j.exger.2016.09.002
Glerup, S., Bolcho, U., Bøggild, S., Vaegter, C. B., Smith, A. H., Nieto-Gonzalez, J. L., Ovesen, P. L., Pedersen, L. F., Fjorback, A. N., Kjolby, M., Login, H., Holm, M. M., Andersen, O. M., Nyengaard, J. R., Willnow, T. E.
, Jensen, K., Nykjaer, A. & Jensen, S. M. (2016).
SorCS2 is required for BDNF-dependent plasticity in the hippocampus.
Molecular Psychiatry,
21(12), 1740-1751.
https://doi.org/10.1038/mp.2016.108
Demontis, D., Lescai, F., Børglum, A., Glerup, S., Østergaard, S. D., Mors, O., Li, Q., Liang, J., Jiang, H., Li, Y., Wang, J., Lesch, K.-P., Reif, A., Buitelaar, J. K. & Franke, B. (2016).
Whole-Exome Sequencing Reveals Increased Burden of Rare Functional and Disruptive Variants in Candidate Risk Genes in Individuals With Persistent Attention-Deficit/Hyperactivity Disorder.
Journal of the American Academy of Child and Adolescent Psychiatry,
55(6), 521-3.
https://doi.org/10.1016/j.jaac.2016.03.009
Buttenschøn, H. N., Demontis, D., Ollendorff, M. K., Elfving, B., Jensen, S. M., Gustafsen, C., Kærlev, L.
, Petersen, C. M., Børglum, A., Mors, O. & Pedersen, S. G. (2015).
Increased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF.
Translational Psychiatry,
5(e677).
https://doi.org/10.1038/tp.2015.167
Buttenschøn, H. N., Demontis, D., Kaas, M.
, Elfving, B., mølgaard, S.
, Gustafsen, C., Kærlev, L.
, Petersen, C. M., Børglum, A., Mors, O.
& Pedersen, S. G. (2015).
Increased sortilin in depression.
Glerup, S., Olsen, D., Vægter, C. B., Gustafsen, C., Sjøgaard, S., Hermey, G., Kjølby, M. F., Jensen, S. M., Ulrichsen, M., Hansen, S. B., Skeldal, S., Fjorback, A. N., Nyengaard, J. R., Jacobsen, J.
, Bender, D., Bjarkam, C. R.
, Sørensen, E. S., Füchtbauer, E.-M., Eichele, G.
... Nykjær, A. (2014).
SorCS2 Regulates Dopaminergic Wiring and Is Processed into an Apoptotic Two-Chain Receptor in Peripheral Glia.
Neuron,
82(5), 1074–1087.
https://doi.org/10.1016/j.neuron.2014.04.022
Gustafsen, C., Kjolby, M., Nyegaard, M., Mattheisen, M., Lundhede, J.
, Buttenschøn, H., Mors, O., Bentzon, J. F., Madsen, P., Nykjaer, A. & Glerup, S. (2014).
The Hypercholesterolemia-Risk Gene SORT1 Facilitates PCSK9 Secretion.
Cell Metabolism,
19(2), 310-8.
https://doi.org/10.1016/j.cmet.2013.12.006
Kløverpris, S., Skov, L. L., Glerup, S., Pihl, K., Christiansen, M.
& Oxvig, C. (2013).
Formation of high-molecular-weight angiotensinogen during pregnancy is a result of competing redox reactions with the proform of eosinophil major basic protein.
Biochemical Journal,
449(1), 209-217.
https://doi.org/10.1042/BJ20120801
Olsen, D., Kaas, M., Schwartz, O.
, Nykjaer, A. & Glerup, S. (2013).
Loss of BDNF or its receptors in three mouse models has unpredictable consequences for anxiety and fear acquisition.
Learning & Memory (Online),
20(9), 499-504.
https://doi.org/10.1101/lm.032045.113
Glerup, S., Lume, M.
, Olsen, D., Nyengaard, J. R., Vaegter, C. B., Gustafsen, C., Christensen, E. I., Kjolby, M., Hay-Schmidt, A.
, Bender, D., Madsen, P., Saarma, M.
, Nykjaer, A. & Petersen, C. M. (2013).
SorLA Controls Neurotrophic Activity by Sorting of GDNF and Its Receptors GFRα1 and RET.
Cell Reports,
3, 186-199.
https://doi.org/10.1016/j.celrep.2012.12.011
Gustafsen, C., Glerup, S., Pallesen, L. T., Olsen, D., Andersen, O. M., Nykjær, A., Madsen, P. & Petersen, C. M. (2013).
Sortilin and SorLA Display Distinct Roles in Processing and Trafficking of Amyloid Precursor Protein.
Journal of Neuroscience,
33(1), 64-71.
https://doi.org/10.1523/JNEUROSCI.2371-12.2013
Breiderhoff, T.
, Christiansen, G. B., Pallesen, L. T., Vægter, C. B., Nykjaer, A., Holm, M. M., Glerup, S. & Willnow, T. E. (2013).
Sortilin-Related Receptor SORCS3 Is a Postsynaptic Modulator of Synaptic Depression and Fear Extinction.
PLOS ONE,
8(9), e75006.
https://doi.org/10.1371/journal.pone.0075006Skeldal, S., Sykes, A. M.
, Glerup, S., Matusica, D., Palstra, N., Autio, H., Boskovic, Z.
, Madsen, P., Castrén, E.
, Nykjaer, A. & Coulson, E. J. (2012).
Mapping of the Interaction Site between Sortilin and the p75 Neurotrophin Receptor Reveals a Regulatory Role for the Sortilin Intracellular Domain in p75 Neurotrophin Receptor Shedding and Apoptosis.
Journal of Biological Chemistry,
287(52), 43798-809.
https://doi.org/10.1074/jbc.M112.374710
Klinger, S. C., Højland, A., Gustafsen, C., Glerup, S., Kjølby, M. F., Helms, H. C.
, Raarup, M. K., Olivecrona, G., Brodin, B.
, Petersen, C. M., Nykjær, A. & Nielsen, M. S. (2012).
SorLA regulates trafficking of Lipoprotein Lipase in polarized cells and astrocytes. Poster session presented at Barriers of the CNS, New London NH, United States.
Klinger, S. C., Glerup, S., Raarup, M. K., Mari, MC.
, Nyegaard, M., Koster, G.
, Prabakaran, T., Nilsson, SK.
, Kjærgaard, M. M., Bakke, O.
, Nykjær, A., Olivecrona, G.
, Petersen, C. M. & Nielsen, MS. (2011).
SorLA regulates lipoprotein lipase activity by intracellular trafficking. Poster session presented at PhD Day 2011, Aarhus University, Faculty of Health Sciences, Aarhus, Denmark.
Klinger, S. C., Glerup, S., Raarup, M. K., Mari, MC.
, Nyegaard, M., Koster, G.
, Prabakaran, T., Nilsson, SK.
, Kjærgaard, M. M., Bakke, O.
, Nykjær, A., Olivecrona, G.
, Petersen, C. M. & Nielsen, MS. (2011).
SorLA regulates lipoprotein lipase activity by intracellular trafficking. Abstract from PhD Day 2011, Aarhus University, Faculty of Health Sciences, Aarhus, Denmark.
Klinger, S. C., Glerup, S., Raarup, M. K., Mari, M. C.
, Nyegaard, M., Koster, G.
, Prabakaran, T., Nilsson, B. S.
, Kjaergaard, M. M., Bakke, O.
, Nykjær, A., Olivecrona, G.
, Petersen, C. M. & Nielsen, M. S. (2011).
SorLA regulates the activity of lipoprotein lipase by intracellular trafficking.
Journal of Cell Science,
124(Pt 7), 1095-105.
https://doi.org/10.1242/jcs.072538
Vaegter, C. B., Jansen, P., Fjorback, A. W., Glerup, S., Skeldal, S., Kjølby, M. F., Richner, M., Erdmann, B.
, Nyengaard, J. R., Tessarollo, L., Lewin, G. R., Willnow, T. E., Chao, M. V.
& Nykjaer, A. (2011).
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.
Nature Neuroscience,
14(1), 54-61.
https://doi.org/10.1038/nn.2689
Andersen, O. S., Boisguerin, P.
, Glerup, S., Skeldal, S., Volkmer, R., Wilnow, T. E.
, Nykjær, A. & Andersen, O. M. (2010).
Identification of a linear epitope in sortilin that partakes in pro-neurotropin binding.
Journal of Biological Chemistry, 12210-12222.
Terkelsen, C. J., Oxvig, C., Nørgaard, B. L., Glerup, S., Poulsen, T. S.
, Lassen, J. F., Møller, H. J., Thuesen, L., Falk, E., Nielsen, T. T. & Andersen, H. R. (2008).
Temporal course of pregnancy-associated plasma protein-A in angioplasty-treated ST-elevation myocardial infarction patients and potential significance of concomitant heparin administration.
American Journal of Cardiology,
103(1), 29-35.
https://doi.org/10.1016/j.amjcard.2008.08.027
Glerup, S., Kløverpris, S., Laursen, L. S., Dagnaes-Hansen, F., Thiel, S., Conover, C. A.
& Oxvig, C. (2007).
Cell surface detachment of pregnancy-associated plasma protein-A requires the formation of intermolecular proteinase-inhibitor disulfide bonds and glycosaminoglycan covalently bound to the inhibitor.
Journal of Biological Chemistry,
282(3), 1769-1778.
https://doi.org/10.1074/jbc.M608454200
Boldt, H. B., Glerup, S., Overgaard, M. T., Sottrup-Jensen, L. & Oxvig, C. (2006).
Definition, expression, and characterization of a protein domain in the N-terminus of pregnancy-associated plasma protein-A distantly related to the family of laminin G-like modules. Protein Expr Purif.,
48(2), 261-73.
